Unveiling the multifaceted antitumor effects of interleukin 33 [PDF]
Frontiers in ImmunologyInterleukin 33 (IL-33), once predominantly recognized for its pro-tumoral activities, has emerged as a multifunctional cytokine with antitumor properties.
Leire Arrizabalaga +10 more
doaj +4 more sources
Interleukin-33 and Obesity-Related Inflammation and Cancer [PDF]
EncyclopediaInterleukin-33 (IL-33) is a cytokine belonging to the IL-1 family. It is primarily associated with type 2 immune responses. It interacts with a receptor complex on immune cells in reaction to tissue damage or cellular injury.
Cameron Kowitt, Qiuyang Zhang
doaj +4 more sources
Full Length Interleukin 33 Aggravates Radiation-Induced Skin Reaction [PDF]
Frontiers in Immunology, 2017 The interleukin (IL)-1 family member IL-33 has been described as intracellular alarmin with broad roles in wound healing, skin inflammation but also autoimmunity.
Olga Kurow +13 more
doaj +8 more sources
Clinical Significance of Interleukin 33 (IL-33) in Patients with Eosinophilic Pneumonia
Allergology International, 2013 Background: Interleukin 33 (IL-33) works as a functional mediator in allergic disease by enhancing the activity of eosinophils and inducing expression of T helper 2 (Th2)-associated cytokines.
Naoko Mato +8 more
doaj +2 more sources
An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice [PDF]
Brazilian Journal of Medical and Biological Research, 2013 Interleukin (IL)-33, the most recent member of the IL family of cytokines, signals through the ST2 receptor. IL-33/ST2 signaling mediates antigen challenge-induced mechanical hyperalgesia in the joints and cutaneous tissues of immunized ...
D.A.C. Magro +9 more
doaj +5 more sources
Interleukin-33 (IL-33) promotes DNA damage-resistance in lung cancer [PDF]
Cell Death and DiseaseResistance to DNA damage is one of the primary mechanisms by which tumor cells evade the effects of standard chemotherapeutic agents and radiotherapy. Dynamic and complex interactions between the tumor microenvironment (TME) and tumor cells critically ...
Haoge Luo +7 more
doaj +2 more sources
Interleukin‐33‐Mediated Mechanical‐Loading Induced Degeneration of Knee Joint Chondrocytes [PDF]
FASEB BioAdvancesOsteoarthritis (OA), a common degenerative joint disorder, continued to present significant challenges in clinical management due to an incomplete understanding of its pathogenesis.
Jiahui Zhang +5 more
doaj +2 more sources
Biological mechanisms and therapeutic prospects of interleukin-33 in pathogenesis and treatment of allergic disease [PDF]
Journal of InflammationAllergic diseases significantly impact the quality of life of people around the world. Cytokines play a crucial role in regulating the immune system. Due to their importance in pro-inflammatory mechanisms, cytokines are used to understand pathogenesis ...
Mohammad Chand Jamali +10 more
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Downregulation of sST2, a decoy receptor for interleukin-33, enhances subcutaneous tumor growth in murine pancreatic cancer cells. [PDF]
FEBS Open BioAkimoto M +5 more
europepmc +3 more sources
Interleukin-33: Friend or Foe in Gastrointestinal Tract Cancers? [PDF]
Cells, 2023 Pisani LF +3 more
europepmc +3 more sources