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Unveiling the multifaceted antitumor effects of interleukin 33 [PDF]
Frontiers in ImmunologyInterleukin 33 (IL-33), once predominantly recognized for its pro-tumoral activities, has emerged as a multifunctional cytokine with antitumor properties.
Leire Arrizabalaga +10 more
doaj +4 more sources
Interleukin-33 and Obesity-Related Inflammation and Cancer [PDF]
EncyclopediaInterleukin-33 (IL-33) is a cytokine belonging to the IL-1 family. It is primarily associated with type 2 immune responses. It interacts with a receptor complex on immune cells in reaction to tissue damage or cellular injury.
Cameron Kowitt, Qiuyang Zhang
doaj +4 more sources
Full Length Interleukin 33 Aggravates Radiation-Induced Skin Reaction [PDF]
Frontiers in Immunology, 2017 The interleukin (IL)-1 family member IL-33 has been described as intracellular alarmin with broad roles in wound healing, skin inflammation but also autoimmunity.
Olga Kurow +13 more
doaj +8 more sources
Interleukin-33: Friend or Foe in Gastrointestinal Tract Cancers? [PDF]
Cells, 2023 Accumulating evidence suggests that Interleukin-33 (IL-33), a member of the IL-1 family, has crucial roles in tissue homeostasis and repair, type 2 immunity, inflammation, and viral infection.
Pisani LF +3 more
europepmc +2 more sources
Hippocampal interleukin-33 mediates neuroinflammation-induced cognitive impairments [PDF]
Journal of Neuroinflammation, 2020 Background Interleukin (IL)-33 is expressed in a healthy brain and plays a pivotal role in several neuropathologies, as protective or contributing to the development of cerebral diseases associated with cognitive impairments.
Flora Reverchon +8 more
doaj +5 more sources
The role of interleukin-33 in organ fibrosis
Discovery Immunology, 2022 Summary Interleukin (IL)-33 is highly expressed in the nucleus of cells present at barrier sites and signals via the ST2 receptor. IL-33 signalling via ST2 is essential for return to tissue homeostasis after acute inflammation, promoting fibrinogenesis ...
Samuele Di Carmine +3 more
semanticscholar +4 more sources
Statin prevents cancer development in chronic inflammation by blocking interleukin 33 expression. [PDF]
Nat CommunChronic inflammation is a major cause of cancer worldwide. Interleukin 33 (IL-33) is a critical initiator of cancer-prone chronic inflammation; however, its induction mechanism by environmental causes of chronic inflammation is unknown.
Park JH +13 more
europepmc +2 more sources
INTERLEUKIN 33 AND FIBROSIS: PATHOGENESIS UPDATED
Медицинская иммунология, 2018 Interleukin 33 (IL-33) is a member of the IL-1 family, which is widely expressed on all types of cells. IL-33 was identified as a functional ligand for the plasma membrane receptor complex, which is a heterodimer consisting of a membrane bound ST2 ...
E. G. Uchasova +3 more
doaj +3 more sources
An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice [PDF]
Brazilian Journal of Medical and Biological Research, 2013 Interleukin (IL)-33, the most recent member of the IL family of cytokines, signals through the ST2 receptor. IL-33/ST2 signaling mediates antigen challenge-induced mechanical hyperalgesia in the joints and cutaneous tissues of immunized ...
D.A.C. Magro +9 more
doaj +5 more sources
Journal of Translational Medicine, 2020 Background Interleukin-33 (IL-33) is an effective inducer of pro-inflammatory cytokines regulating innate and adaptive immunity. Inflammation could be a double-edged sword, promoting or inhibiting tumour growth. To date, the roles and mechanisms of IL-33
Wenxiu Wang +3 more
doaj +2 more sources