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Role of interleukin 33 in human immunopathology
Annals of the Rheumatic Diseases, 2010Interleukin 33 (IL33) is a recently described member of the IL1 superfamily of cytokines. Originally defined on the basis of T-cell subset differentiation, IL33 is now recognised to mediate a wider role in regulating components of the innate immune response also, particularly via mast cell activation.
G E J, Murphy +3 more
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Interleukin-33 and Atherosclerosis
2011Interleukin (IL)-33 (also known as IL-1 F11) is a newly identified member of the IL-1 cytokine family with close amino acid sequence homology to IL-18 [1]. The human and mouse sequences for IL-33 have been mapped to chromosomes 9 (9p24.1) and 19 (19qc1), encoding proteins of 270 and 266 amino acids respectively.
Foo Y. Liew, Ashley M. Miller
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Tranilast inhibits interleukin-33 production by macrophages
European Journal of Pharmacology, 2018Tranilast is an anti-allergy medication that inhibits the release of chemical mediators such as histamine. However, the mechanisms underlying its anti-allergy effects are not fully understood. Interleukin (IL)-33, a novel member of the IL-1 cytokine family, promotes T helper type 2 immune responses and plays a pathogenic role in allergic disorders.
Sachiko, Hiraide +2 more
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Clinical & Experimental Allergy, 2008
SummaryBackground IL‐33, an IL‐1‐like cytokine, is a ligand for IL1RL1, which is an important effector molecule of type 2 T helper responses. Although IL‐33/IL1RL1 interaction has been suggested to be important in induction of allergic airway inflammation, serum levels of IL‐33 and the genetic influences of the polymorphisms of IL‐33 in human ...
M, Sakashita +10 more
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SummaryBackground IL‐33, an IL‐1‐like cytokine, is a ligand for IL1RL1, which is an important effector molecule of type 2 T helper responses. Although IL‐33/IL1RL1 interaction has been suggested to be important in induction of allergic airway inflammation, serum levels of IL‐33 and the genetic influences of the polymorphisms of IL‐33 in human ...
M, Sakashita +10 more
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Interleukin-33 safeguards neutrophils in sepsis
Nature Medicine, 2010Cytokines have a fundamental role in orchestrating innate immune responses to bacterial infections. Interleukin-33 (IL-33) is now shown to protect from sepsis by promoting neutrophil influx into the focus of infection (pages 708–712).
Thierry Roger, Thierry Calandra
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Interleukin-33: a regulator of basophils
Blood, 2009The cytokine network controlling basophils has been extended to interleukin-33. This commentary provides an update and summary on this emerging concept.
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Interleukin-33 and oxidative stress in epilepsy patients
Epilepsy Research, 2021İnflammation and oxidative stress plays an important role in the etiology of epilepsy. Interleukin-33 (IL-33), a new member of the cytokine family associated with interleukin-1 (IL-1), has been found to play a role in pathogenesis of central nervous system diseases and cause the production of proinflammatory cytokines and oxidative stress molecules ...
Ozlem Ethemoglu +6 more
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Upregulation of Interleukin-33 in obstructive renal injury
Biochemical and Biophysical Research Communications, 2016Interstitial fibrosis and loss of parenchymal tubular cells are the common outcomes of progressive renal diseases. Pro-inflammatory cytokines have been known contributing to the damage of tubular cells and fibrosis responses after renal injury. Interleukin (IL)-33 is a tissue-derived nucleus alarmin that drives inflammatory responses.
Wei-Yu Chen +6 more
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NMR assignments of the human cytokine interleukin-33
Biomolecular NMR Assignments, 2009We report near complete NMR backbone and side chain assignments of the human cytokine interleukin-33 (IL-33) in solution. IL-33 is the latest addition to the family of interleukin-1 homologous cytokines and was shown to be involved in inflammation and autoimmune diseases.
Andreas, Lingel, Wayne J, Fairbrother
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Targeting interleukin-33 in rheumatoid arthritis
Rheumatology International, 2011Chao, Rong +3 more
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