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An antiproliferative bioassay for interleukin-4
Journal of Immunological Methods, 1996Interleukin-4 (IL-4) is currently being used for therapeutic intervention in a wide range of malignant diseases as an antitumour agent. Although bioassays have been developed that measure the proliferative capacity of IL-4, none measure the antiproliferative activity of this molecule.
L A, Page +3 more
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Interleukin-4 and breast cancer
Breast Cancer, 2000IL-4 is a pleiotropic cytokine produced by T lymphocytes which acts on various cells of such as T and B lymphocytes, monocytes, fibroblast, endothelial cells, macrophages and some others. IL-4 was originally described as a B cell growth factor, and now known to provide potent anti-tumor activity against various tumors, including breast cancer. IL-4 can
S, Nagai, M, Toi
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Interleukin-4 and Cancer Therapy
Cancer Investigation, 1993(1993). Interleukin-4 and Cancer Therapy. Cancer Investigation: Vol. 11, No. 4, pp. 473-486.
R K, Puri, J P, Siegel
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The interleukin-4 family of lymphokines
Current Biology, 1992Evidence has accumulated indicating that four T-cell derived lymphokines, interleukin-4, interleukin-5, granulocyte-macrophage colony stimulating factor and interleukin-3, are closely related. The genes encoding these lymphokines are clustered within a region of 1000 kb, the proteins have a common secondary and spatial organization, and their ...
J L, Boulay, W E, Paul
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Role of interleukin-4 in atherosclerosis
Archives of Pharmacal Research, 2006Vascular endothelial cell injury or dysfunction has been implicated in the onset and progression of cardiovascular diseases including atherosclerosis. A number of previous studies have demonstrated that the pro-oxidative and pro-inflammatory pathways within vascular endothelium play an important role in the initiation and progression of atherosclerosis.
Yong Woo, Lee, Anjali A, Hirani
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Immunology and Allergy Clinics of North America, 2004
Interleukin 4 (IL-4) mediates important pro-inflammatory functions in asthma, including T helper cell type 2 lymphocyte differentiation, induction of IgE production, up-regulation of IgE receptors, expression of vascular cell-adhesion molecule 1, promotion of eosinophil transmigration into the lungs, inhibition of T-lymphocyte apoptosis, and mucus ...
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Interleukin 4 (IL-4) mediates important pro-inflammatory functions in asthma, including T helper cell type 2 lymphocyte differentiation, induction of IgE production, up-regulation of IgE receptors, expression of vascular cell-adhesion molecule 1, promotion of eosinophil transmigration into the lungs, inhibition of T-lymphocyte apoptosis, and mucus ...
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Therapeutic Targeting of the Interleukin-4/Interleukin-13 Signaling Pathway: In Allergy and Beyond
BioDrugs, 2018D. Karo-Atar +3 more
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Site-Specific POxylation of Interleukin-4.
ACS Biomaterials Science & Engineering, 2017Tessa Lühmann +10 more
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