Results 31 to 40 of about 14,492,078 (303)

Interleukin-4 receptor regulation in human monocytic cells [PDF]

open access: yesBlood, 1994
The regulation of the interleukin-4 receptor (IL-4R) was studied at mRNA and protein level in monocytic cells on stimulation with activators of different intracellular signaling pathways and IL-4. Activation of protein kinase C-dependent pathways with phorbol myristate acetate (PMA) or activation of protein kinase A-dependent pathways with DBcAMP and ...
DEWIT, H   +3 more
openaire   +4 more sources

Stoichiometry of the complex of human interleukin‐4 with its receptor [PDF]

open access: yesFEBS Letters, 1994
A large number of cytokines have been shown to possess a four‐helix bundle structure with a unique up‐up‐down‐down connectivity. The receptors for this family of cytokines have been shown to be homologous as well, each possessing two tandem repeats of a fibronectin type III‐like domain. The crystal structure of human growth hormone bound to the soluble
Hoffman, Ross C.   +8 more
openaire   +2 more sources

Interleukin-18 [PDF]

open access: yes, 2003
Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses.
McInnes, I.B.   +2 more
core   +1 more source

Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist : a Mendelian randomisation analysis [PDF]

open access: yes, 2015
Funded by: UK Medical Research Council, British Heart Foundation, UK National Institute for Health Research, National Institute for Health Research Cambridge Biomedical Research Centre, European Research Council, and European Commission Framework ...
D. F. Easton (7608179)   +874 more
core   +5 more sources

New Role for Interleukin‐13 Receptor α1 in Myocardial Homeostasis and Heart Failure

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
Background The immune system plays a pivotal role in myocardial homeostasis and response to injury. Interleukins‐4 and ‐13 are anti‐inflammatory type‐2 cytokines, signaling via the common interleukin‐13 receptor α1 chain and the type‐2 interleukin‐4 ...
Uri Amit   +19 more
doaj   +1 more source

Interleukin-1 regulates multiple atherogenic mechanisms in response to fat feeding [PDF]

open access: yes, 2009
Background: Atherosclerosis is an inflammatory process that develops in individuals with known risk factors that include hypertension and hyperlipidaemia, influenced by diet.
Dower, S.   +25 more
core   +1 more source

Alternate transcription of the Toll-like receptor signaling cascade [PDF]

open access: yes, 2006
Alternate splicing of key signaling molecules in the Toll-like receptor (Tlr) cascade has been shown to dramatically alter the signaling capacity of inflammatory cells, but it is not known how common this mechanism is. We provide transcriptional evidence
Kai, Chikatoshi   +40 more
core   +1 more source

Interleukin-4 (IL4) and Interleukin-4 receptor (IL4RA) polymorphisms in asthma: a case control study [PDF]

open access: yesClinical and Molecular Allergy, 2005
Abstract Background IL4/IL4RA pathway plays an important role in atopy and asthma. Different polymorphisms in IL4 and IL4RA genes have been described. Particularly, -33C>TIL4 and 576Q>RIL4RA SNPs have been independently associated to atopy and asthma.
Lorente Félix   +5 more
openaire   +3 more sources

Differential effects of age on chicken heterophil functional activation by recombinant chicken interleukin-2 [PDF]

open access: yes, 2002
Interleukin-2 (IL-2) exercises an array of biological effects on many cells including the functional activation of cells of the innate immune response.
Pete Kaiser   +5 more
core   +1 more source

Cytoplasmic tail of IL-13Ralpha2 regulates IL-4 signal transduction

open access: yes, 2009
IL (interleukin)-4 and IL-13 are key cytokines in the pathogenesis of allergic inflammatory disease. IL-4 and IL-13 share many functional properties as a result of their utilization of a common receptor complex comprising IL-13Ralpha1 (IL-13 receptor ...
Donna E. Davies   +13 more
core   +1 more source

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