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Interleukin-6 and Soluble Interleukin-6 Receptor: Direct Stimulation of gp130 and Hematopoiesis
Blood, 1998T HE INTERLEUKIN-6 (IL-6) family of cytokines acts via receptor complexes that contain at least one subunit of the signal transducing protein gp130.[1][1] The family comprises IL-6, IL-11, ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), leukemia inhibitory factor (LIF), and oncostatin ...
M, Peters, A M, Müller, S, Rose-John
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Tocilizumab: The first interleukin-6-receptor inhibitor
American Journal of Health-System Pharmacy, 2008The pharmacology, pharmacokinetics, clinical efficacy, safety, and role of tocilizumab in rheumatoid arthritis (RA) are reviewed.Tocilizumab is a novel monoclonal antibody that competitively inhibits the binding of interleukin-6 (IL-6) to its receptor (IL-6R).
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Interleukin‐6, interleukin‐6 receptor gene variant, small‐vessel disease and incident dementia
European Journal of Neurology, 2016Background and purposeMixed neurogenerative and vascular dementia has emerged as the leading cause of dementia in the elderly. Inflammation is implicated in atherosclerosis, cerebral small‐vessel disease (SVD) as well as cognitive impairment. However, longitudinal data on the predictive value of circulating inflammatory markers including gene variants ...
K, Miwa +4 more
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Interleukin-6 and its receptor in autoimmunity
Journal of Autoimmunity, 1992Interleukin-6 (IL-6) is a multifunctional cytokine which acts on a wide variety of cells, regulating immune response, acute phase reaction and hematopoiesis. In accordance with its pleiotropic functions, IL-6 is indicated to be involved in the pathogenesis of several diseases including autoimmunities, lymphoid malignancies and inflammations.
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Receptors for Interleukin-6 (IL-6)
1995Abstract The human IL-6 receptor consists of 468 amino acids, including a signal peptide of 19 amino acids, an extracellular region of 339 amino acids, a membrane-spanning region of 28 amino acids, and a cytoplasmic region of 82 amino acids (Yamasaki et al. 1988) (GenBank accession numbers M20566, X12830).
M Narazaki, T Kishimoto
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The Soluble Interleukin‐6 Receptora
Annals of the New York Academy of Sciences, 1995S, Rose-John +3 more
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