Results 41 to 50 of about 253,192 (255)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Evaluation of the efficacy and safety of levilimab in the treatment of patients with rheumatoid arthritis in real practice

Терапевтический архив
Aim. To evaluate the efficacy and safety of levilimab (LVL) in patients with rheumatoid arthritis (RA) in real clinical practice. Materials and methods.
Elvina R. Myasoutova, Alina R. Iuskaeva, Liana S. Kostakova, Elena V. Sukhorukova, Rifkat Z. Abdrakipov, Diana I. Abdulganieva, Nikita M. Taratorkin   +6 more
doaj   +1 more source

Efficacy and safety of levilimab in the treatment of patients with rheumatoid arthritis [PDF]

Терапевтический архив
Aim. Evaluation in real clinical practice of the effectiveness and safety of levilimab therapy in patients with highly and moderately active rheumatoid arthritis (RA). Materials and methods.
Elena V. Bolotova, Evgeniya V. Yakovleva, Ekaterina K. Ilinykh, Тatiana A. Rassovskaya   +3 more
doaj   +1 more source

d(GGGT)₄and r(GGGU)₄are both HIV-1 inhibitors and interleukin-6 receptor aptamers [PDF]

RNA Biology, 2013
Aptamers are oligonucleotides that bind targets with high specificity and affinity. They have become important tools for biosensing, target detection, drug delivery and therapy. We selected the quadruplex-forming 16-mer DNA aptamer AID-1 [d(GGGT) 4] with affinity for the interleukin-6 receptor (IL-6R) and identified single nucleotide variants that ...
Magbanua, Eileen, Zivkovic, Tijana, Hansen, Björn, Beschorner, Niklas, Meyer, Cindy, Lorenzen, Inken, Grötzinger, Joachim, Hauber, Joachim, Torda, Andrew E., Mayer, Günter, Rose-John, Stefan, Hahn, Ulrich   +11 more
openaire   +2 more sources

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Constitutive and B-cell receptor-induced activation of STAT3 are important signaling pathways targeted by bortezomib in leukemic mantle cell lymphoma

Haematologica, 2010
Background The deregulation of several transcription factors contribute to the aggressive course of mantle cell lymphoma. This study focuses on survival signals emanating from the tumor environment and involving the signal transducer and activator of ...
Fanny Baran-Marszak, Mohand Boukhiar, Stéphanie Harel, Christelle Laguillier, Claudine Roger, Remy Gressin, Antoine Martin, Remi Fagard, Nadine Varin-Blank, Florence Ajchenbaum-Cymbalista, Dominique Ledoux   +10 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Giant Cell Arteritis Refractory to Interleukin‐6 and Interleukin‐17 Inhibition Treated With Upadacitinib

ACR Open Rheumatology
Giant cell arteritis (GCA) is a granulomatous vasculitis that can involve both cranial and extracranial vessels. Although interleukin‐6 (IL‐6) receptor blockade is an established therapy, treatment options for medically refractory disease remain limited.
Luke S. Vest, Anam Ahmad, Sanhitha Valasareddy, Nancy Phillips, Adam Kilian   +4 more
doaj   +1 more source

Palmitic Acid Induces Production of Proinflammatory Cytokines Interleukin-6, Interleukin-1β, and Tumor Necrosis Factor-α via a NF-κB-Dependent Mechanism in HaCaT Keratinocytes

Mediators of Inflammation, 2013
To investigate whether palmitic acid can be responsible for the induction of inflammatory processes, HaCaT keratinocytes were treated with palmitic acid at pathophysiologically relevant concentrations.
Bing-rong Zhou, Jia-an Zhang, Qian Zhang, Felicia Permatasari, Yang Xu, Di Wu, Zhi-qiang Yin, Dan Luo   +7 more
doaj   +1 more source

BIOCHEMICAL PATHWAYS OF METABOLIC DISORDERS IN PSORIASIS

Juvenis Scientia, 2021
The development of metabolic disorders occurs in psoriasis: insulin resistance, systemic inflammation, atherosclerosis, oxidative stress and obesity. The paper presents pathological biochemical pathways of metabolic disorders development which is caused ...
O. V. Samburskaya, S. Yu Kalinchenko, N. V. Batkaeva   +2 more
doaj   +1 more source