Results 21 to 30 of about 253,192 (255)
Soluble human interleukin‐6‐receptor modulates interleukin‐6‐dependent N‐glycosylation of α1‐protease inhibitor secreted by HepG2 cells [PDF]
FEBS Letters, 1992 Interleukin‐6 (IL‐6) induces changes in gene expression and the N‐glycosylation pattern of acute‐phase proteins in hepatocytes. IL‐6 exerts its action via a cell surface receptor complex consisting of an 80 kDa IL‐6 binding protein (gp80) and a 130 kDa glycoprotein (gp130) involved in signal transduction.
Mackiewicz, Andrzej +5 more
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Clinical pharmacology and therapy, 2022 Levilimab is a monoclonal antibody targeting interleukin-6 receptors and having a potent anti-inflammatory activity. Efficacy and safety of levilimab for treatment of rheumatoid arthritis were established in multicenter, double blind, placebo-controlled clinical trials AURORA and SOLAR.
S. Moiseev +6 more
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Effect of IRAK1/4 inhibitor on IL-1β, IL-6, INF-γ and TNF-α expression in breast cancer cells of several lines [PDF]
The Ukrainian Biochemical Journal, 2021 Recent studies have shown that inflammation mediated via interleukin-1 receptor-associated kinases (IRAKs) is associated with cancer cells drug resistance.
M. Rezaei +4 more
doaj +1 more source
Journal of Pharmacological Sciences, 2006 .: Overexpression of constitutively active (CA)-Gα13 significantly increased the expression of interleukin (IL)-1β and IL-6 mRNAs and proteins in rat cardiac fibroblasts.
Nagamatsu Yuichi +7 more
doaj +1 more source
Leptin induces IL-6 expression through OBRl receptor signaling pathway in human synovial fibroblasts. [PDF]
PLoS ONE, 2013 BACKGROUND: Leptin, an adipocyte-secreted hormone that centrally regulates weight control, may exert proinflammatory effects in the joint, depending on the immune response.
Wei-Hung Yang +6 more
doaj +1 more source
Biomedicines, 2021 Background: Vascular endothelial cells activation and dysfunction mediate inflammation and abnormal coagulation in COVID-19 patients. Mineralocorticoid receptor (MR) signaling and its downstream target Galectin-3 (Gal-3) are known to mediate ...
Eva Jover +7 more
doaj +1 more source
Response to Treatment with an Anti-Interleukin-6 Receptor Antibody (Tocilizumab) in a Patient with Hemophagocytic Syndrome Secondary to Immune Checkpoint Inhibitors [PDF]
Case Reports in Oncological Medicine, 2021 Background. Immunotherapy represents one of the fundamental treatments in the management of some types of cancer, especially malignant melanoma. Toxicity derived from increased immune system activity can manifest in multiple organs and systems.
Alejandro Olivares-Hernández +9 more
openaire +3 more sources
Two Biosensors for the Determination of Interleukin-6 in Blood Plasma by Array SPRi
Biosensors, 2022 Interleukin-6 (IL-6) is a biomarker of inflammation, the advanced stage of COVID-19, and several cancers, including ovarian cancer. Two biosensors for the determination of IL-6 in blood plasma by array SPRi have been developed.
Beata Szymanska +5 more
doaj +1 more source
Haematologica, 2010 Background The histone deacetylase inhibitor ITF2357 has potent cytotoxic activity in multiple myeloma in vitro and has entered clinical trials for this disease.Design and Methods In order to gain an overall view of the activity of ITF2357 and identify ...
Katia Todoerti +10 more
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Frontiers in Immunology, 2023 IntroductionDietary tryptophan (Trp) has been shown to influence fish feed intake, growth, immunity and inflammatory responses. The purpose of this study was to investigate the effect and mechanism of Trp on immune system of juvenile northern snakehead ...
Xin Zhang +7 more
doaj +1 more source