Results 11 to 20 of about 259,269 (302)

Dynamics of modified cardiovascular risk factors in patients with rheumatoid arthritis on the background of 5-year therapy with an interleukin 6 receptor inhibitor

Научно-практическая ревматология
The effect of an inhibitor of interleukin (IL) 6 receptors on the state of the cardiovascular system in patients with rheumatoid arthritis (RA) remains poorly understood, especially with its long-term use.The aim – to study the effect of therapy with the
E. V. Gerasimova, T. V. Popkova, I. G. Kirillova, D. A. Gerasimova, E. L. Nasonov   +4 more
doaj   +3 more sources

Interleukin 6 Receptor Inhibitor Levilimab in the Treatment of Rheumatoid Arthritis

Effective Pharmacotherapy, 2022
The inhibitors of the biological effects of interleukin 6 (IL-6) are the most actively developing group of biologics for the treatment of rheumatoid arthritis (RA) due to pleiotropic effects of this most important pro-inflammatory cytokine, which stimulates a number of processes that play an important role in the pathogenesis of RA.
D.E. Karateev, E.L. Luchikhina
openaire   +3 more sources

Safety and efficacy of interleukin-6-receptor inhibitors in the treatment of neuromyelitis optica spectrum disorders: a meta-analysis [PDF]

BMC Neurology, 2021
Abstract Background Interleukin-6-receptor inhibitors like Tocilizumab and Satralizumab are showing promising results in the treatment of Neuromyelitis Optica spectrum disorder (NMOSD). We aimed to investigate the efficacy and safety of various Interleukin-6-receptor inhibitors in the management of NMO/NMOSD.
Sanjeev Kharel, Suraj Shrestha, Rajeev Ojha, Neha Guragain, Rakesh Ghimire   +4 more
openaire   +3 more sources

A form of circulating interleukin-6 receptor component soluble gp130 as a potential interleukin-6 inhibitor in inflammatory bowel disease [PDF]

Clinical and Experimental Immunology, 2005
SummaryThe presence and the role of soluble gp130, the soluble form of a component of the interleukin (IL)-6 receptor complex, were investigated in inflammatory bowel disease. The serum concentrations of soluble gp130 were increased in ulcerative colitis (active disease, median, 93·5 ng/ml; interquartile range, 26–125 ng/ml; inactive disease, 81 ng/ml,
K, Mitsuyama, N, Tomiyasu, A, Suzuki, K, Takaki, H, Takedatsu, J, Masuda, H, Yamasaki, S, Matsumoto, O, Tsuruta, A, Toyonaga, M, Sata   +10 more
openaire   +2 more sources

Response to Treatment with an Anti-Interleukin-6 Receptor Antibody (Tocilizumab) in a Patient with Hemophagocytic Syndrome Secondary to Immune Checkpoint Inhibitors [PDF]

Case Reports in Oncological Medicine, 2021
Background. Immunotherapy represents one of the fundamental treatments in the management of some types of cancer, especially malignant melanoma. Toxicity derived from increased immune system activity can manifest in multiple organs and systems.
Alejandro Olivares-Hernández, Luis Figuero-Pérez, María A. Amores Martín, Lorena Bellido Hernández, Laura Mezquita, María del Rosario Vidal Tocino, Félix López Cadenas, Felipe Gómez-Caminero López, Roberto A. Escala-Cornejo, Juan Jesús Cruz Hernández   +9 more
openaire   +4 more sources

Selective immune suppression using interleukin-6 receptor inhibitors for management of immune-related adverse events

Journal for ImmunoTherapy of Cancer, 2023
Background Management of immune-related adverse events (irAEs) is important as they cause treatment interruption or discontinuation, more often seen with combination immune checkpoint inhibitor (ICI) therapy. Here, we retrospectively evaluated the safety and effectiveness of anti-interleukin-6 receptor (anti-IL-6R ...
Faisal Fa'ak, Maryam Buni, Adewunmi Falohun, Huifang Lu, Juhee Song, Daniel H Johnson, Chrystia M Zobniw, Van A Trinh, Muhammad Osama Awiwi, Nourel Hoda Tahon, Khaled M Elsayes, Kaysia Ludford, Emma J Montazari, Julia Chernis, Maya Dimitrova, Sabina Sandigursky, Jeffrey A Sparks, Osama Abu-Shawer, Osama Rahma, Uma Thanarajasingam, Ashley M Zeman, Rafee Talukder, Namrata Singh, Sarah H Chung, Petros Grivas, May Daher, Ala Abudayyeh, Iman Osman, Jeffrey Weber, Jean H Tayar, Maria E Suarez-Almazor, Noha Abdel-Wahab, Adi Diab   +32 more
openaire   +3 more sources

IL-1Ra Protects Hepatocytes from CCl4-Induced Hepatocellular Apoptosis via Activating the ERK1/2 Pathway

Pharmaceutical Fronts, 2020
Interleukin-1 receptor antagonist is an important acute-phase protein and an immune mediator, and its expression is associated with the development of hepatitis or acute liver failure.
Ying Zheng, Xinyi Xiao, Zhuoyi Yang, Meiqi Zhou, Hui Chen, Siyi Bai, Jianwei Zhu, Yunsheng Yuan   +7 more
doaj   +1 more source

Use of tocilizumab in the combination treatment of a COVID-19 patient with concomitant rheumatoid arthritis (a case report)

Zaporožskij Medicinskij Žurnal, 2021
The aim is to familiarize practitioners with the clinical case of tocilizumab use in the combination treatment of the coronavirus disease (COVID-19) patient with concomitant rheumatoid arthritis. Materials and methods.
V. A. Vizir, A. S. Sadomov, O. V. Demidenko   +2 more
doaj   +1 more source

Dasatinib for treatment of CAR T-cell therapy-related complications

Journal for ImmunoTherapy of Cancer, 2022
Cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) are severe, potentially life-threatening side effects of chimeric antigen receptor T-cell (CAR T) therapy caused by the release of cytokines by ...
Jakob R Passweg, Dominik Heim, Katharina Baur, Astrid Beerlage, Anna S Poerings, Bastian Kopp, Michael Medinger, Jan C Dirks, Andreas Holbro   +8 more
doaj   +1 more source

Soluble human interleukin‐6‐receptor modulates interleukin‐6‐dependent N‐glycosylation of α₁‐protease inhibitor secreted by HepG2 cells [PDF]

FEBS Letters, 1992
Interleukin‐6 (IL‐6) induces changes in gene expression and the N‐glycosylation pattern of acute‐phase proteins in hepatocytes. IL‐6 exerts its action via a cell surface receptor complex consisting of an 80 kDa IL‐6 binding protein (gp80) and a 130 kDa glycoprotein (gp130) involved in signal transduction.
Mackiewicz, Andrzej, Rose-John, Stefan, Schooltink, Heidi, Laciak, Maria, Górny, Aleksander, Heinrich, Peter   +5 more
openaire   +3 more sources