Results 31 to 40 of about 259,269 (302)

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence [PDF]

, 2005
Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses.
Nathan W. Bartlett, Geoffrey L. Smith, Haga, Ismar R, Geraldine Maloney, Bowie, Andrew G., Bartlett, Nathan W., Martina Schröder, Ismar R. Haga, Haga, Ismar R., Patrick C. Reading, Andrew G. Bowie, Fitzgerald, Katherine A, Smith, Geoffrey L, Schroeder, Martina, Reading, Patrick C, Smith, Geoffrey L., Katherine A. Fitzgerald, Bartlett, Nathan W, Julianne Stack, Maloney, Geraldine, Bowie, Andrew G, Schröder, Martina, Reading, Patrick C., Stack, Julianne, Fitzgerald, Katherine A.   +24 more
core   +1 more source

Stattic sensitizes osteosarcoma cells to epidermal growth factor receptor inhibitors via blocking the interleukin 6-induced STAT3 pathway [PDF]

Acta Biochimica et Biophysica Sinica, 2021
Osteosarcoma (OS), the most common malignant bone tumor with high metastatic potential, frequently affects children and adolescents. Epidermal growth factor receptor (EGFR)-targeted tyrosine kinase inhibitors exhibit encouraging anti-tumor activity for patients with solid tumors, whereas their effects on OS remain controversial.
Shenglin, Wang, Yunqing, Wang, Zhen, Huang, Hongxiang, Wei, Xinwen, Wang, Rongkai, Shen, Wenbin, Lan, Guangxian, Zhong, Jianhua, Lin   +8 more
openaire   +2 more sources

Heterotrimeric G Protein Gα13-Induced Induction of Cytokine mRNAs Through Two Distinct Pathways in Cardiac Fibroblasts

Journal of Pharmacological Sciences, 2006
.: Overexpression of constitutively active (CA)-Gα13 significantly increased the expression of interleukin (IL)-1β and IL-6 mRNAs and proteins in rat cardiac fibroblasts.
Nagamatsu Yuichi, Nishida Motohiro, Onohara Naoya, Fukutomi Masashi, Maruyama Yoshiko, Kobayashi Hiroyuki, Sato Yoji, Kurose Hitoshi   +7 more
doaj   +1 more source

Beneficial Effects of Mineralocorticoid Receptor Pathway Blockade against Endothelial Inflammation Induced by SARS-CoV-2 Spike Protein

Biomedicines, 2021
Background: Vascular endothelial cells activation and dysfunction mediate inflammation and abnormal coagulation in COVID-19 patients. Mineralocorticoid receptor (MR) signaling and its downstream target Galectin-3 (Gal-3) are known to mediate ...
Eva Jover, Lara Matilla, Mattie Garaikoetxea, Amaya Fernández-Celis, Pieter Muntendam, Frédéric Jaisser, Patrick Rossignol, Natalia López-Andrés   +7 more
doaj   +1 more source

Expression levels of the JAK/STAT pathway in the transition from hormone-sensitive to hormone-refractory prostate cancer [PDF]

, 2007
The main cause of prostate cancer-related mortality is the development of hormone-refractory disease. Circulating serum levels of IL-6 are raised in hormone-refractory prostate cancer patients and evidence from cell line studies suggests that the IL-6R ...
Tam, L., Traynor, P., P Traynor, McGlynn, L.M., L Tam, Mukherjee, R., J M S Bartlett, J Edwards, Bartlett, J.M.S., Edwards, J., L M McGlynn, R Mukherjee   +11 more
core   +1 more source

Regulation of thrombopoietin receptor expression and function [PDF]

, 2004
Of the many cells in the body, the hematopoietic cells are among those with the highest rate of self-renewal and turnover. The production and destruction of these cells are tightly controlled by a number of hematopoietic growth factors, in particular by ...
Coers, Jörn
core   +1 more source

Interleukin-6: A Potential Biomarker of Resistance to Multitargeted Receptor Tyrosine Kinase Inhibitors in Castration-resistant Prostate Cancer [PDF]

Urology, 2011
To determine if cellular interleukin-6 production predicts response to tyrosine kinase inhibitors (TKIs). As clinical experience using TKIs in patients with castration-resistant prostate cancer (CRPC) matures, Phase II trials show a heterogeneous response to sunitinib in CRPC patients.
Alexander, Kutikov, Peter, Makhov, Konstantin, Golovine, Daniel J, Canter, Mohit, Sirohi, Ryan, Street, Jay, Simhan, Robert G, Uzzo, Vladimir M, Kolenko   +8 more
openaire   +2 more sources

Clinical Outcomes in Patients with Rheumatoid Arthritis After Switching Between Interleukin-6-Receptor Inhibitors and Janus Kinase Inhibitors: Findings from an Observational Study

Rheumatology and Therapy, 2023
This observational study evaluated response in patients with rheumatoid arthritis (RA) who switched from an interleukin-6 receptor inhibitor (IL-6Ri) to a Janus kinase inhibitor (JAKi) and vice versa.Adult patients with RA, who initiated IL-6Ri or JAKi (following discontinuation of JAKi or IL-6Ri, respectively) during/after December 2012 and had a 6 ...
Anisha B. Dua, Kerri Ford, Stefano Fiore, Dimitrios A. Pappas, Jud C. Janak, Taylor Blachley, Carla Roberts-Toler, Kelechi Emeanuru, Joel M. Kremer, Alan Kivitz   +9 more
openaire   +4 more sources

Pleiotropic anti-myeloma activity of ITF2357: inhibition of interleukin-6 receptor signaling and repression of miR-19a and miR-19b

Haematologica, 2010
Background The histone deacetylase inhibitor ITF2357 has potent cytotoxic activity in multiple myeloma in vitro and has entered clinical trials for this disease.Design and Methods In order to gain an overall view of the activity of ITF2357 and identify ...
Katia Todoerti, Valentina Barbui, Olga Pedrini, Marta Lionetti, Gianluca Fossati, Paolo Mascagni, Alessandro Rambaldi, Antonino Neri, Martino Introna, Luigia Lombardi, Josée Golay   +10 more
doaj   +1 more source

Effects of dietary tryptophan on the antioxidant capacity and immune response associated with TOR and TLRs/MyD88/NF-κB signaling pathways in northern snakehead, Channa argus (Cantor, 1842)

Frontiers in Immunology, 2023
IntroductionDietary tryptophan (Trp) has been shown to influence fish feed intake, growth, immunity and inflammatory responses. The purpose of this study was to investigate the effect and mechanism of Trp on immune system of juvenile northern snakehead ...
Xin Zhang, Anran Wang, Enhui Chang, Bei Han, Jie Xu, Yu Fu, Xiaojing Dong, Shuyan Miao   +7 more
doaj   +1 more source