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Fibroblast Activation Protein Promotes Thoracic Aortic Dissection via PLAUR/ITGB1‐Mediated Pro‐inflammatory Macrophage Polarization

Advanced Science, EarlyView.
This study reveals that FAP promotes thoracic aortic dissection (TAD) through a nonenzymatic mechanism involving fibroblast‐macrophage crosstalk via the FAP/PLAUR/ITGB1/FAK axis. Targeting this pathway might offer a promising therapeutic strategy for TAD.
Hongqiao Zhu, Jianlie Wu, Ziyi Xu, Yifei Pei, Zaiping Jing, Jian Zhou, Rui Feng, Junjun Liu   +7 more
wiley   +1 more source

Interleukin 8-CXCR2-mediated neutrophil extracellular trap formation in biliary atresia associated with neutrophil extracellular trap-induced stellate cell activation. [PDF]

Hepatology
Luo Y, Fraser L, Jezykowski J, Gupta NA, Miethke AG, Taylor SA, Alonso EM, Horslen S, Kohli R, Molleston JP, Kamath BM, Guthery SL, Loomes KM, Magee JC, Rosenthal P, Valentino P, Sokol RJ, Mack CL, Childhood Liver Disease Research Network.   +18 more
europepmc   +1 more source

Inhibition of Interleukin-8/C-X-C Chemokine Receptor 2 Signaling Axis Prevents Tumor Growth and Metastasis in Triple-Negative Breast Cancer Cells. [PDF]

Pharmacology
Jeong Y, Yoon SY, Jung SP, Nam SJ, Lee JE, Kim S.   +5 more
europepmc   +1 more source

Preliminary results and a theoretical perspective of co‑treatment using a miR‑93‑5p mimic and aged garlic extract to inhibit the expression of the pro‑inflammatory interleukin‑8 gene. [PDF]

Exp Ther Med
Gambari R, Papi C, Gasparello J, Agostinelli E, Finotti A.   +4 more
europepmc   +1 more source

The Comparison of Serum Interleukin-8 Levels Based on Severity of Liver Cirrhosis. [PDF]

Med Arch
Rey I, Effendi-Ys R, Sukatendel K.
europepmc   +1 more source

Interleukin-8/CXCR1 Signaling Contributes to the Progression of Pulmonary Adenocarcinoma Resulting in Malignant Pleural Effusion. [PDF]

Cells
Chang YM, Huang WY, Yang SH, Jan CI, Nieh S, Lin YS, Chen SF, Lin YC.   +7 more
europepmc   +1 more source

An electrochemical immunosensor based on a nano-ceria integrated microfluidic chip for interleukin-8 biomarker detection. [PDF]

Nanoscale Adv
Bhardwaj H, Hashmi Z, Singh AK, Kumar G, Lakshmi GBVS, Solanki PR.   +5 more
europepmc   +1 more source

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Interleukin-8: An evolving chemokine

Cytokine, 2022
Early in the 1980s several laboratories mistakenly reported that partially purified interleukin-1 (IL-1) was chemotactic for neutrophils. However, further investigations by us, revealed that our purified IL-1 did not have neutrophil chemotactic activity and this activity in the LPS-stimulated human monocyte conditioned media could clearly be separated ...
Kouji, Matsushima, De, Yang, Joost J, Oppenheim   +2 more
openaire   +2 more sources