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Critical Care Medicine, 2005 Chemokines are chemotactic cytokines, and interleukin (IL)-8 represents the prototypical chemokine. As the name chemokine indicates, IL-8 is responsible for inducing chemotaxis, which is the directed migration of cells to a site of inflammation ...
D. Remick
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Interleukin-8: An evolving chemokine
Cytokine, 2022 Early in the 1980s several laboratories mistakenly reported that partially purified interleukin-1 (IL-1) was chemotactic for neutrophils. However, further investigations by us, revealed that our purified IL-1 did not have neutrophil chemotactic activity and this activity in the LPS-stimulated human monocyte conditioned media could clearly be separated ...
Kouji, Matsushima +2 more
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The Interleukin-8 Pathway in Cancer [PDF]
Clinical Cancer Research, 2008 Abstract Interleukin-8 (IL-8) is a proinflammatory CXC chemokine associated with the promotion of neutrophil chemotaxis and degranulation. This chemokine activates multiple intracellular signaling pathways downstream of two cell-surface, G protein–coupled receptors (CXCR1 and CXCR2).
Waugh, David J.J., Wilson, Catherine
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Interleukin-8 and Interleukin-17 for Cancer
Cancer Investigation, 2014 Pro-inflammatory cytokines have been associated with chronic inflammation and inflammatory diseases. Increased levels of interleukins (ILs) have been associated with inflammatory disease exacerbation. ILs levels have been observed to be associated with advance stage cancer for several types of cancer and a poor prognostic maker for malignant disease ...
Paul, Zarogoulidis +5 more
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Interleukin-8 in health and disease [PDF]
Molecular BiomedicineCytokines are among the main factors involved in indirect cell-to-cell communication in physiological and pathological conditions. In this way, cytokines are soluble and tissue-resident easily detectable biomarkers for the diagnosis and the prediction of
Chiara Bazzichetto +14 more
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Genetic Variants of Interleukin-8 and Interleukin-16 and Their Association with Cervical Cancer Risk [PDF]
LifeBackground: Cervical cancer (CC) is the fourth most common cancer diagnosis in women worldwide. Infection with high-risk human papillomavirus (HPV) is a critical but not determinative condition for CC development, as several co-factors modulate the ...
Rafał Watrowski +8 more
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Interleukin‐8, a chemotactic and inflammatory cytokine
FEBS Letters, 1992 Interleukin‐8 (IL‐8) belongs to a family of small, structurally related cytokines similar to platelet factor 4. It is produced by phagocytes and mesenchymal cells exposed to inflammatory stimuli (e.g., interleukin‐1 or tumor necrosis factor) and activates neutrophils inducing, chemotaxis, exocytosis and the respiratory burst.
Baggiolini M, Clark-Lewis I
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Interleukin-8 as a Biomarker for Disease Prognosis of Coronavirus Disease-2019 Patients
Frontiers in Immunology, 2021 The widespread prevalence of coronavirus disease-2019 (COVID-19) which is caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has resulted in a severe global public health emergency.
Lili Li +16 more
semanticscholar +1 more source
Journal of Innate Immunity, 2021 A sufficient response of neutrophil granulocytes stimulated by interleukin (IL)-8 is vital during systemic inflammation, for example, in sepsis or severe trauma. Moreover, IL-8 is clinically used as biomarker of inflammatory processes.
S. Bernhard +14 more
semanticscholar +1 more source
Serum levels of interleukin-6 and interleukin-8 as diagnostic markers of acute pyelonephritis in children [PDF]
Korean Journal of Pediatrics, 2013 PurposeEarly diagnosis and treatment of acute pyelonephritis in children is of special importance in order to prevent serious complications. This study was conducted to determine the diagnostic value of serum interleukin (IL)-6 and IL-8 in children with ...
Abolfazl Mahyar +6 more
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