Results 61 to 70 of about 1,122,542 (370)
Inflammatory Biomarkers of Traumatic Brain Injury
Pharmaceuticals, 2022 Traumatic brain injury (TBI) has a complex pathology in which the initial injury releases damage associated proteins that exacerbate the neuroinflammatory response during the chronic secondary injury period.
Nathan H. Johnson +9 more
doaj +1 more source
Signaling and Function of Interleukin-2 in T Lymphocytes.
Annual Review of Immunology, 2018 The discovery of interleukin-2 (IL-2) changed the molecular understanding of how the immune system is controlled. IL-2 is a pleiotropic cytokine, and dissecting the signaling pathways that allow IL-2 to control the differentiation and homeostasis of both
S. Ross, D. Cantrell
semanticscholar +1 more source
Localized Interleukin-12 for Cancer Immunotherapy
Frontiers in Immunology, 2020 Interleukin-12 (IL-12) is a potent, pro-inflammatory type 1 cytokine that has long been studied as a potential immunotherapy for cancer. Unfortunately, IL-12's remarkable antitumor efficacy in preclinical models has yet to be replicated in humans.
Khue G Nguyen +6 more
semanticscholar +1 more source
Journal of Leukocyte Biology, 2003 Abstract Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses. IL-18 is expressed at sites of chronic inflammation, in autoimmune diseases, in a variety of cancers, and in the context of numerous infectious diseases.
Gracie, J.A. +2 more
openaire +3 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Liposomic lubricants suppress shear-stress induced inflammatory gene regulation in the joint in vivo [PDF]
arXiv, 2023 Osteoarthritis (OA) is a widespread, debilitating joint disease associated with articular cartilage degradation. It is driven via mechano-inflammatory catabolic pathways, presumed up-regulated due to increased shear stress on the cartilage-embedded chondrocytes, that lead to tissue degeneration.
arxiv
Effects of Huaiqihuang Granules adjuvant therapy in children with primary nephrotic syndrome
Open Life Sciences, 2019 This study aims to observe the curative effect of Huaiqihuang Granules adjuvant therapy on primary nephrotic syndrome (PNS).
Zhou Ping +9 more
doaj +1 more source
Optimization of Capture ELISAs for Chicken Cytokines Using Commercially Available Antibodies
Animals, 2022 Cytokines like interferon (IFN)-γ, interleukin (IL)-2, IL-6, IL-10, and IL-12p40 are important biomarkers for characterizing the nature and strength of immune responses.
Paulina Krzysica +5 more
doaj +1 more source
Interleukin-6 Family Cytokines.
Cold Spring Harbor Perspectives in Biology, 2018 The interleukin (IL)-6 family cytokines is a group of cytokines consisting of IL-6, IL-11, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), cardiotrophin 1 (CT-1), cardiotrophin-like cytokine (CLC), and IL-27 ...
S. Rose-John
semanticscholar +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source