Results 1 to 10 of about 349,293 (286)

Fibromodulin selectively accelerates myofibroblast apoptosis in cutaneous wounds by enhancing interleukin 1β signaling [PDF]

Nature Communications
Activated myofibroblasts deposit extracellular matrix material to facilitate rapid wound closure that can heal scarlessly during fetal development.
Wenlu Jiang, Xiaoxiao Pang, Pin Ha, Chenshuang Li, Grace Xinlian Chang, Yuxin Zhang, Lawrence A. Bossong, Kang Ting, Chia Soo, Zhong Zheng   +9 more
doaj   +2 more sources

Role of interleukin 1β and interleukin 10 variants on ocular toxoplasmosis in Brazilian individuals

Frontiers in Ophthalmology, 2023
IntroductionOcular toxoplasmosis (OT) is an intraocular inflammation caused by Toxoplasma gondii infection that affects the retina and choroid, giving rise to posterior uveitis.
Warlen Miiller Rocha Araujo, Christiane Maria Ayo, Mariana Previato, Mariana Previato, Geraldo Magela de Faria, Fábio Batista Frederico, Fábio Batista Frederico, Rubens Camargo Siqueira, Gildásio Castello de Almeida, Gildásio Castello de Almeida, Vera Lúcia Pereira-Chioccola, Luiz Carlos de Mattos, Cinara Cássia Brandão   +12 more
doaj   +1 more source

The NLRP3 inflammasome – interleukin 1β axis in uveal melanoma

FEBS Open Bio, 2023
Uveal melanoma (UM) is the most common primary intraocular cancer in the adult population. Recent studies suggested that the NLRP3 inflammasome could be a therapeutic target for cutaneous melanoma (CM), but the role of NLRP3 in UM remains unknown.
Victor S. M. C. Correa, Nikolaos E. Efstathiou, Dimitrios P. Ntentakis, Zhen Yu, Toshio Narimatsu, Evangelos Gragoudas, Ivana K. Kim, Demetrios G. Vavvas   +7 more
doaj   +1 more source

Sleeve gastrectomy and pancreas omentoplasty improved β cell insulin expression and interleukin-1β serum level in non-obese diabetes mellitus rat

Bali Medical Journal, 2021
Background: Diabetes mellitus is one of the health problems that is growing rapidly today. In Asia, majority of the population are non-obese with Type 2 Diabetes Mellitus (T2DM). Two main defects of T2DM, insulin resistance and impaired insulin secretion due to reduced pancreatic β cells.
Erlangga Dimas, Abdul Mughni, Chemy Wiryawan, Vito Mahendra, Ignatius Riwanto   +4 more
openaire   +1 more source

NF-κB-dependent role for cold-inducible RNA binding protein in regulating interleukin 1β. [PDF]

PLoS ONE, 2013
The cold inducible RNA binding protein (CIRBP) responds to a wide array of cellular stresses, including short wavelength ultraviolet light (UVC), at the transcriptional and post-translational level.
Christian Brochu, Miguel A Cabrita, Brian D Melanson, Jeffrey D Hamill, Rosanna Lau, M A Christine Pratt, Bruce C McKay   +6 more
doaj   +1 more source

Regulation by Nrf2 of IL-1β-induced inflammatory and oxidative response in VSMC and its relationship with TLR4

Frontiers in Pharmacology, 2023
Introduction: Vascular oxidative stress and inflammation play an important role in the pathogenesis of cardiovascular diseases (CVDs). The proinflammatory cytokine Interleukin-1β (IL-1β) participates in the vascular inflammatory and oxidative responses ...
Zoe González-Carnicero, Raquel Hernanz, Raquel Hernanz, Marta Martínez-Casales, María Teresa Barrús, Ángela Martín, Ángela Martín, María Jesús Alonso, María Jesús Alonso   +8 more
doaj   +1 more source

The Role of Interleukin 1β in the Pathogenesis of Lung Cancer

JTO Clinical and Research Reports, 2020
Introduction: Chronic inflammation is associated with an increased risk of several diseases, including cancer. A complex tumor microenvironment created and maintained by a range of cell types promotes tumor growth, angiogenesis, and metastasis ...
Edward B. Garon, MD, James Chih-Hsin Yang, MD, PhD, Steven M. Dubinett, MD   +2 more
doaj   +1 more source

Methylation-Dependent Gene Silencing Induced by Interleukin 1β via Nitric Oxide Production [PDF]

The Journal of Experimental Medicine, 1999
Interleukin (IL)-1β is a pleiotropic cytokine implicated in a variety of activities, including damage of insulin-producing cells, brain injury, or neuromodulatory responses. Many of these effects are mediated by nitric oxide (NO) produced by the induction of NO synthase (iNOS) expression. We report here that IL-1β provokes a marked repression of genes,
Hmadcha, Abdelkrim, Bedoya Bergua, Francisco Javier, Sobrino, Francisco, Pintado Sanjuán, Elizabeth   +3 more
openaire   +4 more sources

Protein kinase C-ε contributes to a chronic inhibitory effect of IL-1β on voltage-gated sodium channels in mice with febrile seizure [PDF]

Journal of Integrative Neuroscience, 2019
This study aimed to understand the role of Interleukin-1β in mouse febrile seizures. To investigate the chronic effects of raised Interleukin-1β on seizures, the sodium currents of hippocampal neurons were recorded by whole-cell voltage clamp ...
Jinli Wang, Fenfen Xu, Yuan Zheng, Xu Cheng, Piaopiao Zhang, Hongyang Zhao
doaj   +1 more source

Peptidoglycan and teichoic acid fromStaphylococcus epidermidisstimulate human monocytes to release tumour necrosis factor-α, interleukin-1β and interleukin-6 [PDF]

FEMS Immunology & Medical Microbiology, 1993
Cytokines play a major role in the pathophysiology of septic shock. In this study, human peripheral blood monocytes were stimulated with peptidoglycan and teichoic acid, purified from a strain of Staphylococcus epidermidis. Polymyxin B (PM-B) was added to avoid the effects of possible contamination with endotoxin.
E, Mattsson, L, Verhage, J, Rollof, A, Fleer, J, Verhoef, H, van Dijk   +5 more
openaire   +2 more sources