Results 291 to 300 of about 1,132,369 (355)

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

Advanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai   +12 more
wiley   +1 more source

Interplay of Interleukin-1<b>β</b> and Curcumin on VEGF Expression in Breast Cancer Cells. [PDF]

Oncol Res
Nass N, Ignatov A, Kalinski T.
europepmc   +1 more source

Tailored Porous Bimetallic Nanozyme Platform for Full‐Cycle Therapeutics of Intestinal Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative‐inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA‐Cu‐Ma nanocomposite functions as a dual‐phase therapeutic platform with significant efficacy. It rapidly
Chenghao Qiu, Wenjing Xian, Mengxue Wang, Guozhi Zhao, Yanhuo Zhang, Zhiyu Zhou, Bo Sheng, Zhuo Zhen, Xie Liu, Shouwen Diao, Mengwei Tu, Chen Qiu, Huixian Wang, Jianbo Zhang, Peng Zhu, Tong Li   +15 more
wiley   +1 more source

Comparative Efficacy and Safety of Colchicine and Anti-Interleukin-1 Agents in Recurrent Pericarditis: A Pairwise and Network Meta-Analysis of Randomized Controlled Trials. [PDF]

J Am Heart Assoc
Ehsan M, Syed AB, Mustafa B, Ikram J, Khan MH, Cremer PC, Imazio M, Wang TKM, Klein AL.   +8 more
europepmc   +1 more source

Heparan sulfate fine-tuned interleukin-1 (IL-1) signaling inhibits insulin secretion of grafted pancreatic islets. [PDF]

Sci Adv
Wrublewsky S, Rother S, Pohlemann F, Radanovic T, Junker F, Boewe AS, Schunk S, Roma LP, Ruiz-Gómez G, Pisabarro MT, MacDonald PE, Menger MD, Laschke MW, Ampofo E.   +13 more
europepmc   +1 more source

Diagnosis, management, and monitoring of interleukin-1 mediated diseases in Central and Eastern Europe: real-world data. [PDF]

Pediatr Rheumatol Online J
Jelusic M, Sestan M, Toplak N, Tamas C, Vojinovic J, Zuber Z, Wolska-Kusnierz B, Sparchez M, Jesenak M, Rusoniene S, Stanevica V, Dolezalova P, Harel L, Uziel Y, Gattorno M.   +14 more
europepmc   +1 more source

The correlation between Interleukin 1 β (IL-1β) as an inflammatory marker and Malondialdehyde (MDA) as a lipid peroxidation marker and the development of cardiac and pancreatic complications in humans suspected to scorpion poisoning. [PDF]

BMC Pharmacol Toxicol
Mebed GR, Zakaria MS, Setouhi A, Rezk MNN.   +3 more
europepmc   +1 more source

The Arabidopsis TIRome informs the design of artificial TIR (Toll/interleukin-1 receptor) domain proteins

Bayless AM, Song L, Sorbello M, Ogden SC, Todd TS, Flint A, Maruta N, Tulu J, Drenichev M, Ntoukakis V, Ve T, Mobli M, Wan L, Liu Q, Dangl JL, Kobe B, Grant M, Nishimura MT.   +17 more
europepmc   +1 more source

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Interleukin-1

The International Journal of Biochemistry & Cell Biology, 1998
Interleukin 1 (IL1) is a primary regulator of inflammatory and immune responses. Via its type I receptor it activates specific protein kinases, including the NF kappa B inducing kinase (NIK) and three distinct mitogen-activated protein (MAP) kinase cascades.
E, Stylianou, J, Saklatvala
openaire   +3 more sources