Results 291 to 300 of about 4,629,468 (340)
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1995
Abstract The mouse IL-13 cDNA (GenBank accession number M23504) encodes a protein of 131 amino acids (Brown eta/. 1989). The human IL-13 (hlL-13) cDNA (GenBank accession No L06801) encodes a protein of 132 amino acids (McKenzie et al. 1993a; Minty eta/. 1993).
A N J McKenzie, G Zurawski
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Abstract The mouse IL-13 cDNA (GenBank accession number M23504) encodes a protein of 131 amino acids (Brown eta/. 1989). The human IL-13 (hlL-13) cDNA (GenBank accession No L06801) encodes a protein of 132 amino acids (McKenzie et al. 1993a; Minty eta/. 1993).
A N J McKenzie, G Zurawski
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Interleukin-13 in asthma pathogenesis
Current Allergy and Asthma Reports, 2004Summary: Bronchial asthma is a complex disorder that is thought to arise as a result of aberrant T‐lymphocyte responses to noninfectious environmental antigens. In particular, the symptoms of asthma are closely associated with the presence of activated T‐helper 2 cell (Th2) cytokine‐producing cells [interleukin (IL)‐4, IL‐5, IL‐9, and IL‐13] in the ...
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Interleukin-13 and Leukotrienes
American Journal of Respiratory Cell and Molecular Biology, 2003The episodic wheezing and shortness of breath caused by events in asthma, have not been extensively investigated. In this issue of the AJRCMB, Vargaftig and Singer address asthma has been recognized since antiquity. As a result, major efforts have been directed at studies of asthma pathothis gap in our knowledge and demonstrate, for the first time ...
Jack A, Elias +4 more
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Journal of Receptors and Signal Transduction, 1999
Synovial fibroblasts expressed transcripts for IL-4R alpha, and IL-13R alpha 1 and IL-13R alpha 2. Using weighted nonlinear computer modeling of the data from equilibrium binding studies, a 2 bindings sites model fitted the data best. After occupation of the shared high affinity receptors by the non-signaling, double mutant IL-4(121)R-->D, 124Y-->D (RY-
R A, Lutz, N, Feng, R, Moser
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Synovial fibroblasts expressed transcripts for IL-4R alpha, and IL-13R alpha 1 and IL-13R alpha 2. Using weighted nonlinear computer modeling of the data from equilibrium binding studies, a 2 bindings sites model fitted the data best. After occupation of the shared high affinity receptors by the non-signaling, double mutant IL-4(121)R-->D, 124Y-->D (RY-
R A, Lutz, N, Feng, R, Moser
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Interleukin-13: Characterization and biologic properties
1995Upon activation by antigen, helper T cells respond by secreting factors, called cytokines, that coordinate the immune response. The type of T-cell response initiated depends upon the antigenic stimulus and can result in a polarization of the spectrum of cytokines secreted.
A N, McKenzie, G, Zurawski
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Journal of Cellular Biochemistry, 2009
AbstractIL‐13 is a central mediator of allergic inflammation and secreted by Th2 and bronchial smooth muscle cells (BSMC). However, little is known about the regulation of IL‐13 secretion. To address it, a cDNA library of BSMC was screened for the proteins interacted with IL‐13 by yeast two‐hybridization.
Hongyan, Liang +4 more
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AbstractIL‐13 is a central mediator of allergic inflammation and secreted by Th2 and bronchial smooth muscle cells (BSMC). However, little is known about the regulation of IL‐13 secretion. To address it, a cDNA library of BSMC was screened for the proteins interacted with IL‐13 by yeast two‐hybridization.
Hongyan, Liang +4 more
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Role of Interleukin-13 in Asthma
Current Allergy and Asthma Reports, 2013Interleukin-13 is a pleiotropic TH2 cytokine that has been shown to be central to the pathogenesis of asthma. Some of the most prominent of the effects of IL-13 include increases in goblet cell differentiation, activation of fibroblasts, elevation of bronchial hyperresponsiveness, and switching of B cell antibody production from IgM to IgE.
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Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity
Cancer Cell, 2022Yared Hailemichael +2 more
exaly
Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19
New England Journal of Medicine, 2021Anthony C Gordon +2 more
exaly