Results 101 to 110 of about 579,790 (305)

Identification of fused pyrimidines as interleukin 17 secretion inhibitors

, 2018
Inhibiting the interleukin 17 pathway is of interest in a number of autoimmune diseases. Herein, 42 fused pyrimidines have been evaluated as interleukin 17 secretion inhibitors using a phenotypic assay with peripheral blood mononuclear cells.
Sundby, Eirik, Jin Han, Bård Helge Hoff, Han, Jin, Reiersølmoen, Ann Christin, Hoff, Bård Helge, Ann Christin Reiersølmoen, Eirik Sundby   +7 more
core   +2 more sources

Milk fat globule E-8 and interleukin 17 in systemic lupus erythematosus: partners in crime?

, 2016
Objectives: Systemic lupus erythematosus (SLE) is a multi-factorial, autoimmune disease with a wide array of manifestations. The pro-inflammatory cytokine interleukin (IL)-17 has been implicated in the inflammatory response and tissue damage in SLE ...
Fatema Elgengehy, Shada Ghoneim, Marwa Niazy, Lamiaa Madkour   +3 more
core   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Interleukin-25 Produced by Synoviocytes Has Anti-inflammatory Effects by Acting As a Receptor Antagonist for Interleukin-17A Function

Frontiers in Immunology, 2017
The production and function of cytokines are highly regulated. One mechanism is the balance between pro- and anti-inflammatory cytokines. As interleukin (IL)-17A and IL-25 share the IL-17RA receptor chain, we hypothesize that IL-25 acts as an IL-17A ...
Fabien Lavocat, Ndiémé Ndongo-Thiam, Pierre Miossec   +2 more
doaj   +1 more source

Efficacy and safety of monoclonal antibodies targeting interleukin-17 pathway for inflammatory arthritis: a meta-analysis of randomized controlled clinical trials

, 2016
Min Wei,1 Dongmei Duan21Department of Orthopedics, 2Department of Traditional Chinese Medicine, People’s Liberation Army General Hospital, Beijing, People’s Republic of China Abstract: T-helper 17 (Th17) pathway plays an important and ...
Wei M, Duan D
core  

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Sex-dependent susceptibility to Listeria monocytogenes infection is mediated by differential interleukin-10 production [PDF]

, 2005
It is well documented that sex-dependent factors affect susceptibility to infection, with most mouse models demonstrating higher resistance in females.
Bastian Pasche, Helmut Fuchs, Andreas Lengeling, Hrabě de Angelis, M., Franz, T.J., Busch, D.H., Tobias J. Franz, Pasche, B., Busch, Dirk H, Busch, Dirk H., Kalaydjiev, S., Kremmer, E., Valérie Gailus-Durner, Martin Hrabé de Angelis, Kremmer, Elisabeth, Franz, Tobias J., De Angelis, Martin Hrabé, Pasche, Bastian, Dirk H. Busch, Lengeling, A., Fuchs, H., Fuchs, Helmut, Kalaydjiev, Svetoslav, Gailus-Durner, Valérie, Hrabé de Angelis, Martin, Lengeling, Andreas, Svetoslav Kalaydjiev, Gailus-Durner, V., Franz, Tobias J, Elisabeth Kremmer   +29 more
core   +1 more source

Design and Synthesis of Peptide‐Polyester Conjugates for Cell‐Mediated Scaffold Degradation

Advanced Healthcare Materials, EarlyView.
This work describes polycaprolactone (PCL)‐based biomaterials engineered to degrade in response to cell‐secreted proteases. A fast‐degrading peptide (Fast) sequence is integrated into a PCL conjugate backbone to produce a biomaterial that is selectively degraded by multiple cell types compared to its scrambled control (ScrFast).
Korina Vida G. Sinad, Natasha K. Hunt, Srujan Singh, Kelly B. Seims, Yingjie Wu, E. Thomas Pashuck, Warren L. Grayson, Lesley W. Chow   +7 more
wiley   +1 more source

Interleukin-6 and Interleukin-17 gene polymorphisms and celiac disease susceptibility

The Turkish Journal of Gastroenterology, 2017
Cite this article as: Ecevit ÇÖ. Interleukin-6 and Interleukin-17 gene polymorphisms and celiac disease susceptibility. Turk J Gastroenterol 2017; 28: 432-3.
Çiğdem Ömür Ecevit
doaj   +1 more source