Results 91 to 100 of about 63,752,558 (296)

Interleukin 17 deficiency and implications in cutaneous and systemic diseases

Journal of Dermatology and Dermatologic Surgery, 2015
Background: IL17-targeted therapeutics are being developed to treat psoriasis. IL17 is involved in the pathogenesis of many diseases, and the implications of IL17 blockade are not yet well characterized.
Elizabeth Z. Welch, Kathryn L. Anderson, Steven R. Feldman   +2 more
doaj   +1 more source

Changes in Immune‐Inflammation Status and Prognosis in Pregnancy‐Related Cerebral Venous Thrombosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Distinguishing pathological changes from physiological adaptations in pregnancy‐related cerebral venous thrombosis (CVT) is clinically challenging. This study aimed to characterize coagulation, immune‐inflammation, and dehydration status in these patients and assess their prognostic value.
Xiaoming Zhang, Zilin Xu, Ran Duan, Chunxiao Lu, Da Zhou, Chen Zhou, Ran Meng, Xunming Ji   +7 more
wiley   +1 more source

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini, Giulia Tammam, Andra Ezaru, Manuela Gambella, Benoît Sanson, Luisa Villa, Michele Cavalli, Mihai‐Bogdan Ioncea, Angela Puma, Sabrina Sacconi   +9 more
wiley   +1 more source

The effects of anti-interleukin-5 on SABA rescue use.

, 2016
The effects of anti-interleukin-5 on SABA rescue use.
Ting Liu (45625), Fa-Ping Wang (3358667), Hui Mao (115181), Zhu Lan (3358673), Su-Yun Li (3358670)   +4 more
core   +1 more source

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source

Raised interleukin-17 is immunolocalised to neutrophils in cystic fibrosis lung disease

Interleukin-17 is pivotal in orchestrating the activity of neutrophils. Neutrophilic inflammation is the dominant pathology in cystic fibrosis lung disease.
Anderson AE, Brodlie M, McKean MC, Lordan JL, Johnson GE, Fisher AJ, Corris PA, Ward C, Hilkens CM   +8 more
core   +3 more sources

Th17 Lymphocytes in Respiratory Syncytial Virus Infection

Viruses, 2013
Infection by respiratory syncytial virus (RSV) affects approximately 33 million infants annually worldwide and is a major cause of hospitalizations. Helper T lymphocytes (Th) play a central role in the immune response during such infections.
Rizgar A. Mageed, Ali S. Jawad, Mohammed Al-Bogami, Nasra Al-Adhoubi, Jonas Bystrom   +4 more
doaj   +1 more source

Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice

, 2012
Interleukin (IL)-17 signaling has been implicated in lung and skin fibrosis.
Iwaisako, Keiko, Paik, Yonghan, Zhang, Mingjun, Liu, Xiao, Stickel, Felix, Brenner, David A., Cong, Min, Meng, Fanli, Grivennikov, Sergei I, Aoyama, Tomonori, Ley, Klaus, Brenner, David A, Österreicher, Christoph H., Grivennikov, Sergei I., Osterreicher, Christoph H, Kisseleva, Tatiana, Wang, Kai, Scholten, David, Zhang M, Wang K, Liu X, Iwaisako K, Stickel F, Cong M, Aoyama T, Grivennikov SI, Brenner DA, Paik Y, Österreicher CH, Meng F, Kisseleva T, Ley K, Scholten D   +32 more
core   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

Targeting of interleukin-17 in the treatment of psoriasis

, 2014
Ann Sophie Lønnberg, Claus Zachariae, Lone SkovDepartment of Dermato-Allergology, Gentofte Hospital, University of Copenhagen, Hellerup, DenmarkAbstract: “Psoriasis” is a chronic immune-mediated inflammatory disorder with epidermal ...
Skov L, Zachariae C, Lønnberg AS
core