Results 71 to 80 of about 3,701,935 (349)

Interleukin-17 in rheumatoid arthritis: Trials and tribulations

Journal of Experimental Medicine, 2020
IL-17A is a rational therapeutic target in RA; however, clinical trials have shown relatively modest success. This review explores possible reasons for the limited clinical efficacy of IL-17A blockade in RA, guided by recent insights in IL-17 biology.
L. Taams
semanticscholar   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Expressions of IL-17, IL-21 and IL-23 in the serum of allergic rhinitis patients [PDF]

Journal of Medical Biochemistry, 2011
The present study aimed to investigate the expressions of interleukin-17 (IL-17), IL-21 and IL-23 in the serum of allergic rhinitis (AR) patients and to explore their relationship with special IgE (sFgE) in the serum.
Huang Xuekun, Yang Qintai, Chen Yulian, Peng Li, Zhang Gehua, Yuan Li   +5 more
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis [PDF]

, 2012
Type 17 helper T cells have been suggested to play a pathological role in psoriasis. They secrete several proinflammatory cytokines, including interleukin-17A (also known as interleukin-17). We evaluated the safety and efficacy of ixekizumab (LY2439821),
Leonardi, Craig, Zachariae, Claus, Li, Linda, Cameron, Gregory, Banerjee, Subhashis, Matheson, Robert, Edson-Heredia, Emily, Braun, Daniel   +7 more
core   +1 more source

Interleukin-17 Regulates Neuron-Glial Communications, Synaptic Transmission, and Neuropathic Pain after Chemotherapy.

Cell Reports, 2019
The proinflammatory cytokine interleukin-17 (IL-17) is implicated in pain regulation. However, the synaptic mechanisms by which IL-17 regulates pain transmission are unknown.
Hao Luo, Hui-Zhu Liu, Wen-wen Zhang, Megumi Matsuda, Ning Lv, Gang Chen, Zhen-Zhong Xu, Yu-Qiu Zhang   +7 more
semanticscholar   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice [PDF]

, 2012
Interleukin (IL)-17 signaling has been implicated in lung and skin fibrosis.
Iwaisako, Keiko, Paik, Yonghan, Zhang, Mingjun, Liu, Xiao, Stickel, Felix, Brenner, David A., Cong, Min, Meng, Fanli, Grivennikov, Sergei I, Aoyama, Tomonori, Ley, Klaus, Brenner, David A, Österreicher, Christoph H., Grivennikov, Sergei I., Osterreicher, Christoph H, Kisseleva, Tatiana, Wang, Kai, Scholten, David   +17 more
core   +1 more source

Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation

Science immunology, 2019
Interleukin-17 receptor D serves as a functional receptor for Interleukin-17A in psoriasis-like skin inflammation. A new receptor for interleukin-17 The cytokines interleukin-17A (IL-17A) and IL-17F drive immune activation by binding to the IL-17 ...
Yang Su, Jinling Huang, Xiaohong Zhao, Huiping Lu, Wang Wang, Xuexian O. Yang, Yuling Shi, Xiaohu Wang, Y. Lai, C. Dong   +9 more
semanticscholar   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source