Results 61 to 70 of about 3,701,935 (349)

Interleukin-17 in Chronic Inflammatory Neurological Diseases

Frontiers in Immunology, 2020
A critical role for IL-17, a cytokine produced by T helper 17 (Th17) cells, has been indicated in the pathogenesis of chronic inflammatory and autoimmune diseases.
J. Milovanović, A. Arsenijevic, B. Stojanovic, T. Kanjevac, Dragana Arsenijević, G. Radosavljević, M. Milovanovic, N. Arsenijević   +7 more
semanticscholar   +1 more source

Heterogeneity in the granulomatous response to mycobacterial infection in patients with defined genetic mutations in the interleukin 12-dependent interferon-gamma production pathway [PDF]

, 2002
Granulomatous Diseases Review Heterogeneity in the granulomatous response to mycobacterial infection in patients with defined genetic mutations in the interleukin 12-dependent interferon-gamma production ...
Kumararatne, D.S., Baretto, Richard, De Heer, E., J.F. EMILE, Ottenhoff, THM, De Heer, E, Edgar, JD, Binch, J., Ottenhoff, T.H., Casanova, J.L., Lammas, David, Lammas, D.A., Edgar, J, Kumararatne, DS, Panchalingam, S, Novelli, V., E. DE HEER, Drysdale, P, Binch, J, Ottenhoff, TH, Panchalingam, S., Emile, JF, Drysdale, Pamela, C. MACLENNAN, T. H. M. OTTENHOFF, Ben-smith, Anne, Novelli, V, P. DRYSDALE, MacLennan, Calman, R. BARETTO, Casanova, JL, J. BINCH, Ben-Smith, A., Casanova, J-L, Ben-Smith, A, Drysdale, P., Emile, J.F., D. S. KUMARARATNE, Baretto, R, Baretto, R., S. PANCHALINGAM, J.-L. CASANOVA, MacLennan, C, J. D. EDGAR, A. BEN-SMITH, Kumararatne, Dinakantha, D. A. LAMMAS, MacLennan, C., Lammas, David A, V. NOVELLI   +49 more
core   +1 more source

Cytokines (interleukin-9, IL-17, IL-22, IL-25 and IL-33) and asthma

Advanced Biomedical Research, 2014
Asthma is a reversible airway obstruction that is characterized by constriction of airway smooth muscle, hyper secretion of mucus, edema and airway hyper responsiveness (AHR), mucus secretion and thickening of the basement membrane underlying the airway ...
Rahim Farahani, Roya Sherkat, Mazdak Ganjalikhani Hakemi, Nahid Eskandari, Reza Yazdani   +4 more
doaj   +1 more source

Interleukin‐17 and its target genes: mechanisms of interleukin‐17 function in disease [PDF]

Immunology, 2010
SummaryInterleukin‐17 (IL‐17) has emerged as a central player in the mammalian immune system. Although this cytokine exerts a host‐defensive role in many infectious diseases, it promotes inflammatory pathology in autoimmunity and other settings. A myriad of studies have focused on how IL‐17‐producing cells are generated.
Reiko M, Onishi, Sarah L, Gaffen
openaire   +2 more sources

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Differential regulation of interleukin-17 and interferon-y production in inflammatory bowel disease [PDF]

, 2010
PhDBackground and Aims. Interleukin (IL)-17 is now known to be involved in a number of chronic inflammatory disorders. However, the mechanisms regulating its production in inflammatory bowel disease (IBD) are still unclear. Methods.
Rovedatti, Laura
core  

Interleukin 17 receptor-based signaling and implications for disease

Nature Immunology, 2019
IL-17 is a highly versatile pro-inflammatory cytokine crucial for a variety of processes, including host defense, tissue repair, the pathogenesis of inflammatory disease and the progression of cancer.
Xiaoxia Li, R. Bechara, Junjie Zhao, M. McGeachy, S. Gaffen   +4 more
semanticscholar   +1 more source

The role of interleukin-17 in asthma: a protective response?

ERJ Open Research, 2020
While there now exist effective treatments for type 2 high, eosinophilic asthma, there are no specific therapies for 40–50% of people with asthma with other phenotypes, which result from poorly understood underlying pathological mechanisms.
G. Hynes, T. Hinks
semanticscholar   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity

Immunity, 2019
&NA; Production of interleukin‐17 (IL‐17) and IL‐22 by T helper 17 (Th17) cells and group 3 innate lymphoid cells (ILC3s) in response to the gut microbiota ensures maintenance of intestinal barrier function.
María Martínez-López, S. Iborra, Ruth Conde-Garrosa, Annalaura Mastrangelo, C. Danne, E. Mann, Delyth M. Reid, V. Gaboriau-Routhiau, M. Chaparro, M. P. Lorenzo, Lara Minnerup, P. Saz-Leal, E. Slack, B. Kemp, J. Gisbert, A. Dzionek, M. Robinson, F. Rupérez, N. Cerf‐Bensussan, Gordon D. Brown, D. Bernardo, S. Leibundgut-Landmann, D. Sancho   +22 more
semanticscholar   +1 more source