Results 291 to 300 of about 885,440 (356)

Irradiated Tumor Cell‐Derived Microparticles Activate Systemic Anti‐Tumor Immunity via the STING/NLRP3/GSDMD Axis in Neutrophils

Advanced Science, EarlyView.
Radiotherapy induces tumor cells to release microparticles (RT‐MPs) into the circulation. The mitochondrial DNA carried by these RT‐MPs activates the STING/NLRP3/GSDMD axis in splenic neutrophils, triggering IL‐1β secretion. This, in turn, enhances dendritic cell function and facilitates the formation of cytotoxic T lymphocytes, thereby promoting ...
Yan Hu, Jiacheng Wang, Mengjie Che, Zheng Yang, Jingshu Meng, Xiao Yang, Yue Deng, Zhiyuan Zhou, Yijun Wang, Wenwen Wei, Zhanjie Zhang, Bian Wu, You Qin, Kunyu Yang, Honglin Jin, Fang Huang, Yajie Sun, Lu Wen, Chao Wan   +18 more
wiley   +1 more source

Ly6G⁺ Neutrophils and Interleukin-17 Are Essential in Protection against Rodent Malaria Caused by Plasmodium berghei ANKA. [PDF]

Research (Wash D C)
Su Z, Li Q, Zhang Y, Liu T, Lv K, Feng A, Yang Y, Zhang Y, Wei Z, Sang X, Feng Y, Chen R, Jiang N, Chen Q.   +13 more
europepmc   +1 more source

GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer

Advanced Science, EarlyView.
Aberrant glycosylation drives cancer progression, yet its role in the tumor microenvironment remains unclear. We developed GlycoChat to map glycan–lectin circuits at single‐cell resolution. We discovered that cancer cells induce immunosuppressive macrophage differentiation and impair phagocytosis through interactions with CLEC10A and SIGLEC3 ...
Dinh Xuan Tuan Anh, Sunanda Keisham, Arun Burramsetty, Lalhaba Oinam, Koichiro Kumano, Akihiro Kuno, Osamu Shimomura, Tatsuya Oda, Hiroaki Tateno   +8 more
wiley   +1 more source

Metabolic reprogramming of interleukin-17-producing γδ T cells promotes ACC1-mediated de novo lipogenesis under psoriatic conditions. [PDF]

Nat Metab
Kao YS, Lauterbach M, Lopez Krol A, Distler U, Godoy GJ, Klein M, Argüello RJ, Boukhallouk F, Vallejo Fuente S, Braband KL, Nurbekova A, Romero M, Mamareli P, Silva L, Damasceno LEA, Rampoldi F, Berod L, Lynch L, Hiller K, Sparwasser T.   +19 more
europepmc   +1 more source

Design and methods of the Ixekizumab Diabetes Intervention Trial (I-DIT): protocol for a phase 2, randomised, multicentre, placebo-controlled, double-blind trial of anti-interleukin 17 as a treatment option for adults with new-onset type 1 diabetes. [PDF]

BMJ Open
Seyed Ahmadi S, Korsgren O, Jansson PA, Lind M.   +3 more
europepmc   +1 more source

CD25 downregulation by tumor exosomal microRNA-15a promotes interleukin-17-producing γδ-T-cells-mediated radioresistance in nasopharyngeal carcinoma. [PDF]

MedComm (2020)
Wang X, Xiang Z, Zhang Y, Tu CR, Huang C, Chung Y, Zhang W, Wang M, Liu Y, Tu W.   +9 more
europepmc   +1 more source

Intra-class switch among interleukin-17 inhibitors for the treatment of plaque psoriasis: a single-center experience. [PDF]

Dermatol Reports
Ghezzi G, Ibba L, Gargiulo L, Narcisi A, Costanzo A, Valenti M.   +5 more
europepmc   +1 more source

Interleukin-4 and Interleukin-17 are associated with coronary artery disease. [PDF]

Clin Cardiol
Wang C, Liu S, Yang Y, Kamronbek R, Ni S, Cheng Y, Zhou C, Yan H, Li L, Liu H, Wang Y, Qin Y, Yin C, Zhang M.   +13 more
europepmc   +1 more source