Results 321 to 330 of about 4,008,604 (402)

Elevated SPARC Disrupts the Intestinal Barrier Integrity in Crohn's Disease by Interacting with OTUD4 and Activating the MYD88/NF‐κB Pathway

Advanced Science, Volume 12, Issue 11, March 20, 2025.
This study reveals that SPARC activates the MYD88/NF‐κB/MLCK/MLC2 pathway by interacting directly with OTUD4, leading to intestinal barrier damage. In addition, the METTL3‐YTHDF1 axis promotes SPARC expression. Therefore, targeting SPARC or the OTUD4/MYD88/NF‐κB/MLCK/MLC2 axis may provide new insights into the molecular basis of CD and may serve as an ...
Jiayu Wang, Yuxin He, Xingchao Zhu, Jinghan Zhu, Zilin Deng, Huan Zhang, Yanjun Chen, Guangbo Zhang, Tongguo Shi, Weichang Chen   +9 more
wiley   +1 more source

Interleukin-23 versus Interleukin-17 Inhibitors in Preventing Incidental Psoriatic Arthritis in Patients with Psoriasis: A Real-World Comparison From the TriNetX US Collaborative Network. [PDF]

BioDrugs
Yu S, Huo AP, Wang YH, Wei JC.
europepmc   +1 more source

Chromosome Missegregation Triggers Tumor Cell Pyroptosis and Enhances Anti‐Tumor Immunotherapy in Colorectal Cancer

Advanced Science, Volume 12, Issue 12, March 27, 2025.
Immune system disorders and chromosome missegregation are two of the major hallmarks of tumor. The relationship between tumor immune and chromosome missegregation is still unclear. This study reveals that YY2 high expression‐mediated chromosome missegregation/micronuclei formation triggers pyroptosis and CTL activation by activating AIM2/caspase‐1 ...
Wei Duan, Rendy Hosea, Lingxian Wang, Cao Ruan, Fuqiang Zhao, Jingyi Liu, Hezhao Zhao, Makoto Miyagishi, Shourong Wu, Vivi Kasim   +9 more
wiley   +1 more source

Fenofibrate Represses Interleukin-17 and Interferon-γ Expression and Improves Colitis in Interleukin-10–Deficient Mice

, 2007
Jimmy W. Lee, Poonam J. Bajwa, Monica J. Carson, Daniel R. Jeske, Yingzi Cong, Charles O. Elson, Christian Lytle, Daniel S. Straus   +7 more
openalex   +1 more source

Interleukin-17 inhibits development of malignant pleural effusion via interleukin-9-dependent mechanism [PDF]

, 2016
Hua Lin, Huanzhong Shi, Kan Zhai, Qiong Zhou, Xiaojuan Wang, Yong Lu   +5 more
core   +1 more source

Intestinal Gastrin/CCKBR Axis Protects against Type 2 Diabetes by Reducing Intestinal Glucose Absorption through the PI3K/Akt/eIF4B Signaling Pathway

Advanced Science, Volume 12, Issue 13, April 3, 2025.
In intestinal epithelial cells, Gastrin/CCKBR stimulation prevents high glucose‐stimulated SGLT1 (SLC5A1) and GLUT2 (SLCA2) expressions, via the PI3K/AKT/eIF4B signaling pathway, with facilitatory effects on the secretion of incretins, which could be therapeutic targets for clinical treatment in T2D.
Xue Liu, Xing Liu, Yunpeng Liu, Anxiong Long, Wei Liu, Shiyun Sun, Shuaibing Lu, Xianxian Wu, Xiaodi Jia, Pedro A Jose, Qiang Wei, Xiaoliang Jiang, Haizeng Zhang, Zhiwei Yang   +13 more
wiley   +1 more source

Level of interleukin 17 in inflammatory bowel disease and its relation with disease activity. [PDF]

BMC Gastroenterol
Menesy A, Hammad M, Aref S, Abozeid FAM.
europepmc   +1 more source

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

Advanced Science, EarlyView.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin, Lianhua Yin, Weilin Liu, Rui Li, Tao Jiang, Minguang Yang, Yajun Cao, Sinuo Wang, Yan Yu, Cong Chen, Xiaoqin Guo, Wenju Wang, Huanhuan Liu, Yaling Dai, Jiamin Yan, Yanting Lin, Yanyi Ding, Chendong Ruan, Lei Yang, Tiecheng Wu, Jing Tao, Lidian Chen   +21 more
wiley   +1 more source

Single-cell map of innate-like lymphocyte response to <i>Francisella tularensis</i> infection reveals interleukin-17-dependent protection by MAIT cells. [PDF]

iScience
Okoye GD, Kumar A, Ghanbari F, Chowdhury NU, Wu L, Newcomb DC, Van Kaer L, Algood HMS, Joyce S.   +8 more
europepmc   +1 more source

Rational Design of Inner Ear Drug Delivery Systems

Advanced Science, EarlyView.
Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu, Zhiyan Xuan, Haoyu Ren, Keng Chen, Hui Zhang, Huan Wang   +5 more
wiley   +1 more source