Results 331 to 340 of about 4,008,604 (402)

The Relationship Between Soluble Interleukin-17 Receptor Levels and CD3-Positive T Cells and Lymphocytes in Patients with Sepsis and Their Predictive Clinical Significance. [PDF]

J Inflamm Res
Li G, Zhang W, Gu W.
europepmc   +1 more source

Conjugated Lithocholic Acid Activates Hepatic TGR5 to Promote Lipotoxicity and MASLD‐MASH Transition by Disrupting Carnitine Biosynthesis

Advanced Science, EarlyView.
Takeda G protein‐coupled receptor 5 (TGR5) serves as a central regulator in the metabolic dysfunction‐associated steatotic liver disease (MASLD)/metabolic dysfunction‐associated steatohepatitis (MASH) transition via conjugated lithocholic acid (LCA). Mechanistically, TGR5 orchestrates lipotoxicity‐induced cell death through its interaction with CD36 ...
Senlin Lian, Meixi Lu, Luo Jiajing, Bin Zhang, Yi Fang, Xuran Wang, Minghua Zheng, Yan Ni, Guifang Xu, Yonglin Yang, Runqiu Jiang   +10 more
wiley   +1 more source

SCF^FBXW11 Complex Targets Interleukin-17 Receptor A for Ubiquitin-Proteasome-Mediated Degradation. [PDF]

Biomedicines
Jin B, Moududee SA, Ge D, Zhou P, Wang AR, Liu YZ, You Z.   +6 more
europepmc   +1 more source

Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways

, 2008
Kristine Nograles, Lisa C. Zaba, Emma Guttman‐Yassky, Judilyn Fuentes‐Duculan, Mayte Suárez‐Fariñas, Irma Cardinale, Artemis Khatcherian, Juana Gonzalez, Katherine C. Pierson, Traci R. White, Cara A. Pensabene, Israel Coats, Inna Novitskaya, Michelle A. Lowes, James G. Krueger   +14 more
openalex   +1 more source

Targeting p21‐Positive Senescent Chondrocytes via IL‐6R/JAK2 Inhibition to Alleviate Osteoarthritis

Advanced Science, Volume 12, Issue 11, March 20, 2025.
This study uncovers a novel mechanism behind uneven cartilage degeneration in knee osteoarthritis (OA). Elevated IL‐6R expression activates the IL‐6 pathway, leading to SIRT1 degradation, chondrocyte senescence, and reduced SOX9 activity, which impairs cartilage matrix synthesis. Notably, the JAK inhibitor tofacitinib prevents IL‐6R‐mediated senescence,
Xiang Zhao, Jieming Lin, Feng Liu, Yu Zhang, Bo Shi, Chunhui Ma, Ziqi Wang, Song Xue, Qingrong Xu, Hongda Shao, Jingxing Yang, Yanzheng Gao   +11 more
wiley   +1 more source

Interleukin-17: A Putative Novel Pharmacological Target for Pathological Pain. [PDF]

Curr Neuropharmacol
Gao SJ, Liu L, Li DY, Liu DQ, Zhang LQ, Wu JY, Song FH, Zhou YQ, Mei W.   +8 more
europepmc   +1 more source

Interleukin‐17 in host defence against bacterial, mycobacterial and fungal pathogens

, 2008
Meredith M. Curtis, Sing Sing Way
openalex   +2 more sources

β‐Glucuronidase‐Expressing Lactobacillus reuteri Triggers Irinotecan Enterotoxicity Through Depleting the Regenerative Epithelial Stem/Progenitor Pool

Advanced Science, EarlyView.
XLP mitigated CPT11 mucositis by suppressing GUS‐expressing microbes, notably L. reuteri, and diminishing bacterial GUS activity, consequently reducing SN38 accumulation to protect the intestinal epithelium. This preservation of the mucosal stem cell niche enabled rapid regeneration of secretory lineages such as mucin‐producing goblet cells, which ...
Bei Yue, Ruiyang Gao, Ling Zhao, Donghui Liu, Cheng Lv, Ziyi Wang, Fangbin Ai, Beibei Zhang, Zhilun Yu, Xiaolong Geng, Hao Wang, Kang Wang, Kaixian Chen, Chenghai Liu, Zhengtao Wang, Wei Dou   +15 more
wiley   +1 more source

Chemotherapy‐Mediated Induction of PD‐L1 via SEI1 Facilitates Myeloma Immune Evasion

Advanced Science, EarlyView.
Chemotherapy induces DNA damage, activating cyclic guanosine monophosphate (GMP)‐adenosine monophosphate (AMP) synthase (cGAS)/stimulator of interferon genes (STING), which phosphorylates interferon regulatory factor 7 (IRF7) to drive SERTA‐containing domain 1 (SEI1) transcription.
Rui Chen, Zongwei Li, Zhihong Fang, Zou Li, Daoyan Yang, Yuan Li, Shurong Liu, Zhiqiang Liu, Rui Liu, Huan Liu   +9 more
wiley   +1 more source

Gut Microbiota‐Butyrate‐PPARγ Axis Modulates Adipose Regulatory T Cell Population

Advanced Science, EarlyView.
This study identifies the indispensable role of gut microbiota in the maintenance of ST2+ adipose Treg cell population, and defines gut microbiota‐derived butyrate as an endogenous PPARγ agonist, modulating adipose Treg cell populations via promoting PPARγ activation. Butyrate or fiber supplementation restores the VAT ST2+ Treg population in obese mice
Banru Chen, Lizhi Guan, Chao Wu, Yiwen Gong, Lei Wu, Minchun Zhang, Zhiwen Cao, Yufei Chen, Chengcan Yang, Bing Wang, Yunqi Li, Bin Li, Yufang Bi, Guang Ning, Jiqiu Wang, Weiqing Wang, Ruixin Liu   +16 more
wiley   +1 more source