Results 341 to 350 of about 4,008,604 (402)

Fibroblast Activation Protein Acts as a Biomarker for Monitoring ECM Remodeling During Aortic Aneurysm via 68Ga‐FAPI‐04 PET Imaging

Advanced Science, Volume 12, Issue 14, April 10, 2025.
[68Ga]‐FAPI‐04 PET imaging technique represents a potential method to assess the extent of AA remodeling in vivo and may help to identify candidates at potential risk for rapid AA progression. Abstract Traditional imaging modalities used to monitor the diameter of aortic aneurysms (AAs) often fail to follow pathological progression.
Chengkai Hu, Hui Tan, Yuchong Zhang, Genmao Cao, Chenye Wu, Peng Lin, Shouji Qiu, Fandi Mo, Enci Wang, Shiyi Li, Tong Yuan, Zheyun Li, Weiguo Fu, Dengfeng Cheng, Hao Lai, Xiaoyuan Chen, Lixin Wang   +16 more
wiley   +1 more source

Effect of tumour necrotic factor-α, interleukin-17 and interleukin-22 on the expression of filaggerin-2 and hornerin: Analysis of a three-dimensional psoriatic skin model. [PDF]

Skin Health Dis
Makino T, Mizawa M, Takemoto K, Yamamoto S, Shimizu T.   +4 more
europepmc   +1 more source

PRMT1 Ablation in Endothelial Cells Causes Endothelial Dysfunction and Aggravates COPD Attributable to Dysregulated NF‐κB Signaling

Advanced Science, EarlyView.
This study investigates the role of protein arginine methyltransferase 1 (PRMT1) in endothelial cells (ECs) in chronic obstructive pulmonary disease (COPD). Mice with endothelial‐specific PRMT1 deletion develop pulmonary hemorrhage, inflammation, and apoptosis, driven by excessive nuclear factor kappa B activation.
Thi Thuy Vy Tran, Yideul Jeong, Suwoo Kim, Ji Eun Yeom, Jinwoo Lee, Wonhwa Lee, Gyu‐Un Bae, Jong‐Sun Kang   +7 more
wiley   +1 more source

Correlation Between Gut Microbiota Composition and Serum Interleukin 17 (IL-17) in Mice With Type 2 Diabetes and Experimental Periodontitis. [PDF]

Cureus
Mo C, Huang M, Yan F, Song M, Fan J, Zhang J.   +5 more
europepmc   +1 more source

NETs‐CD44‐IL‐17A Feedback Loop Drives Th17‐Mediated Inflammation in Behçet's Uveitis

Advanced Science, Volume 12, Issue 16, April 24, 2025.
In experimental autoimmune uveitis (EAU), neutrophils interact with T helper 17 (Th17) cells through neutrophil extracellular traps (NETs) to exert a pro‐inflammatory effect. In vitro and in vivo experiments identify that NETs promote IL‐17A secretion in Th17 cells via CD44, and increasing IL‐17A further induces more NETs formation.
Yi Wu, Kang Ning, Zhaohao Huang, Binyao Chen, Junjie Chen, Yingying Wen, Jian Bu, Han Hong, Qiaorong Chen, Zhuoqi Zhang, Renbing Jia, Wenru Su   +11 more
wiley   +1 more source

Risk of candidiasis associated with interleukin-17 inhibitors: Implications and management. [PDF]

Mycology
Bilal H, Khan MN, Khan S, Fang W, Chang W, Yin B, Song NJ, Liu Z, Zhang D, Yao F, Wang X, Wang Q, Cai L, Hou B, Wang J, Mao C, Liu L, Zeng Y.   +17 more
europepmc   +1 more source

Dipeptidic Phosphonates: Potent Inhibitors of Pseudomonas aeruginosa Elastase B Showing Efficacy in a Murine Keratitis Model

Advanced Science, Volume 12, Issue 14, April 10, 2025.
A new series of highly potent dipeptidic phosphonates targeting the Pseudomonas aeruginosa protease LasB shows promising in vitro effects, favorable pharmacokinetics, good tolerability, and in vivo efficacy, highlighting their potential as a treatment for Pseudomonas keratitis when combined with meropenem. Abstract The ubiquitous opportunistic pathogen
Alexander F. Kiefer, Christian Schütz, Colya N. Englisch, Dominik Kolling, Samira Speicher, Andreas M. Kany, Roya Shafiei, Noran A. Wadood, Ahmad Aljohmani, Niklas Wirschem, Ravindra P. Jumde, Andreas Klein, Asfandyar Sikandar, Yu‐Mi Park, Gabriela Krasteva‐Christ, Daniela Yildiz, Ahmed S. Abdelsamie, Katharina Rox, Jesko Köhnke, Rolf Müller, Markus Bischoff, Jörg Haupenthal, Anna K. H. Hirsch   +22 more
wiley   +1 more source

Nanoenhanced‐Cuproptosis Results From the Synergy of Calcium Overload and GSH Depletion with the Increasing of Intracellular Ca/Mn/Cu Ions

Advanced Science, Volume 12, Issue 13, April 3, 2025.
In this study, CaCO3/Mn/Cu@lip‐Apt release Mn*, Cu2+, and Ca2+ in cells. The high valence Mn ion in Mn* can effectively consume GSH, allowing more Cu2+ to participate in cuproptosis. This situation will induce the oligomerization of DLAT. The large accumulation of Ca2+ leads to intracellular calcium overload, resulting in metabolism disorders. Finally,
Shiwei Liu, Wennan Yan, Wenyue Zhang, Ji Zhang, Ziyi Li, Yingshu Guo, Hong‐Yuan Chen, Jing‐Juan Xu   +7 more
wiley   +1 more source

HIC1 suppresses Tumor Progression and Enhances CD8+ T Cells Infiltration Through Promoting GSDMD‐induced Pyroptosis in Gastric Cancer

Advanced Science, EarlyView.
These findings elucidate the innovative role of HIC1 as a transcriptional activator in GC, driving the initiation of pyroptosis and enhancing CD8+ T cell infiltration, which has certain novelty and creative significance. Collectively, targeting HIC1 can present an appealing immunotherapeutic strategy to improve outcomes in GC patients.
Mengjie Kang, Wenqi Du, Lina Ding, Mengdi Wu, Dongsheng Pei   +4 more
wiley   +1 more source

Microneedles at the Forefront of Next Generation Theranostics

Advanced Science, EarlyView.
The TOC figure illustrates the revolutionary role of microneedles in modern medicine, showcasing their dual diagnostic and therapeutic functions. On the left, microneedles access interstitial fluid for real‐time monitoring of biomarkers like glucose and hormones.
Chan Wang, Yuan Yang, Jiaqi Zhang, Hanrui Zhang, Qian Wang, Shengmei Ma, Pengfei Zhao, Zhou Li, Yuxin Liu   +8 more
wiley   +1 more source