Results 351 to 360 of about 4,008,604 (402)

Electroacupuncture Reduced Fibromyalgia-Pain-like Behavior through Inactivating Transient Receptor Potential V1 and Interleukin-17 in Intermittent Cold Stress Mice Model. [PDF]

Brain Sci
Yeh YA, Liao HY, Hsiao IH, Hsu HC, Lin YW.   +4 more
europepmc   +1 more source

Tumoroid Model Reveals Synergistic Impairment of Metabolism by Iron Chelators and Temozolomide in Chemo‐Resistant Patient‐derived Glioblastoma Cells

Advanced Science, EarlyView.
This study investigates the metabolic vulnerabilities of glioblastoma (GBM), an aggressive brain tumor. Research demonstrates that iron chelation therapy, in combination with standard chemotherapy, significantly enhances the efficacy of treatment against resistant GBM cells in a 3D tumoroid model.
Meitham Amereh, Amir Seyfoori, Shahla Shojaei, Sarah Lane, Tian Zhao, Mahdieh Shokrollahi Barough, Julian J. Lum, Patrick Walter, Mohsen Akbari   +8 more
wiley   +1 more source

Authors' Reply to Wang et al., "Comment on 'Efficacy and Safety of Brodalumab, an Anti‑interleukin‑17 Receptor A Monoclonal Antibody, for Palmoplantar Pustulosis: 16‑Week Results of a Randomized Clinical Trial'". [PDF]

Am J Clin Dermatol
Okubo Y, Kobayashi S, Murakami M, Sano S, Kikuta N, Ouchi Y, Terui T.   +6 more
europepmc   +1 more source

Immunostimulatory Hydrogel with Synergistic Blockage of Glutamine Metabolism and Chemodynamic Therapy for Postoperative Management of Glioblastoma

Advanced Science, Volume 12, Issue 15, April 17, 2025.
To address the challenge of postoperative recurrence, Combo Gel, a peptide‐based hydrogel that integrates glutamine metabolism modulation with chemodynamic therapy (CDT) is engineered. This innovative system, containing CB‐839 and copper peptide nanoparticles (Cu‐His NPs), enhances CDT's efficacy and promotes immunogenic cell death, thereby ...
Yiran Guo, Tianhe Jiang, Sen Liang, Anhe Wang, Jieling Li, Yi Jia, Qi Li, Jian Yin, Shuo Bai, Junbai Li   +9 more
wiley   +1 more source

Microglia‐Derived Interleukin‐6 Triggers Astrocyte Apoptosis in the Hippocampus and Mediates Depression‐Like Behavior

Advanced Science, Volume 12, Issue 11, March 20, 2025.
In this study, it is observed that chronic social defeat stress (CSDS), an animal model of depression, results in atrophy and apoptosis of hippocampal astrocytes, accompanied by the activation of hippocampal microglia. Furthermore, the deletion and inhibition of microglia, as well as P2X7 receptor (P2X7R) deletion in microglia, mitigate CSDS‐induced ...
Shi‐Yu Shen, Ling‐Feng Liang, Tian‐Le Shi, Zu‐Qi Shen, Shu‐Yuan Yin, Jia‐Rui Zhang, Wei Li, Wen‐Li Mi, Yan‐Qing Wang, Yu‐Qiu Zhang, Jin Yu   +10 more
wiley   +1 more source

Radiotherapy‐Associated Cellular Senescence and EMT Alterations Contribute to Distinct Disease Relapse Patterns in Locally Advanced Cervical Cancer

Advanced Science, Volume 12, Issue 12, March 27, 2025.
The relapse rate for locally advanced cervical cancer (LACC) patients after radiotherapy is 20%–40%. This study shows that the cellular senescence pathway in malignant cells varies among relapse patterns, while EMT module expression is consistently elevated in all relapse patterns.
Lei Zhang, Jun Ma, Jun Zhang, Minjie Hu, Jinlin Cheng, Bin Hu, Junjun Zhou, Di Zhou, Yongrui Bai, Xiumei Ma, Jianming Tang, Haiyan Chen, Ying Jing   +12 more
wiley   +1 more source

Evaluation of serum interleukin-17 A and interleukin-22 levels in pediatric patients with autism spectrum disorder: a pilot study. [PDF]

BMC Pediatr
Sallam DE, Shaker YS, Mostafa GA, El-Hossiny RM, Taha SI, Ahamed MAEH.   +5 more
europepmc   +1 more source

Photoacoustic Imaging in Inflammatory Orthopedic Diseases: Progress toward Precise Diagnostics and Predictive Regulation

Advanced Science, Volume 12, Issue 14, April 10, 2025.
With the intensification of aging issues, inflammatory orthopedic diseases almost occurs in every elderly people, which are becoming increasingly severe. Persistent inflammation of joints often leads to irreversible tissue damage and loss of organ function, while early diagnosis and timely intervention are crucial for reducing the personal and social ...
Mengyi Huang, Haoyu Yu, Rongyao Gao, Yuxin Liu, Xuhui Zhou, Limin Fu, Jing Zhou, Luoyuan Li   +7 more
wiley   +1 more source

Efficacy and Safety of Brodalumab, an Anti-interleukin-17 Receptor A Monoclonal Antibody, for Palmoplantar Pustulosis: 16-Week Results of a Randomized Clinical Trial. [PDF]

Am J Clin Dermatol
Okubo Y, Kobayashi S, Murakami M, Sano S, Kikuta N, Ouchi Y, Terui T.   +6 more
europepmc   +1 more source

Sequential interleukin-17 inhibitors for moderate-to-severe plaque psoriasis who have an IL-17 inhibitors failure in a resource limited country: An economic evaluation. [PDF]

PLoS One
Dilokthornsakul P, Sawangjit R, Noppakun N, Rajatanavin N, Pattamadilok B, Chularojanamontri L, Permsuwan U.   +6 more
europepmc   +1 more source