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Interleukin-8 and Interleukin-17 for Cancer
Cancer Investigation, 2014Pro-inflammatory cytokines have been associated with chronic inflammation and inflammatory diseases. Increased levels of interleukins (ILs) have been associated with inflammatory disease exacerbation. ILs levels have been observed to be associated with advance stage cancer for several types of cancer and a poor prognostic maker for malignant disease ...
Nikolaos Katsikogiannis +5 more
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The role of interleukin-17 in epilepsy
Epilepsy Research, 2022Epilepsy is a common neurological disorder that seriously affects human health. It is a chronic central nervous system dysfunction caused by abnormal discharges of neurons. About 50 million patients worldwide are affected by epilepsy. Although epileptic symptoms of most patients are controllable, some patients with refractory epilepsy have no response ...
Jiayin, An +6 more
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Interleukin-17 in Inflammatory Myopathies
Current Rheumatology Reports, 2012Since the identification of interleukin (IL)-17 as a T-cell-derived cytokine 15 years ago, the contribution of the T-helper type 17 (Th17) pathway in inducing and maintaining chronic inflammation has been well-established, particularly in rheumatoid arthritis. In addition to the main Th1 profile first suggested to contribute to inflammatory myopathies,
Anne Tournadre, Pierre Miossec
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Interleukin-17 and airway remodelling
Pulmonary Pharmacology & Therapeutics, 2006Interleukin (IL)-17A is emerging as important in reinforcing innate immunity by orchestrating sustained neutrophilic mobilisation. Even though there are indications of association with specific airway diseases, there is still no final proof that IL-17A plays a truly causative pathogenic role. There is evidence in mice that endogenous IL-17A contributes
Anders Lindén, Anders Lindén
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Interleukin-17 family and IL-17 receptors
Cytokine & Growth Factor Reviews, 2003Interleukin-17 (IL-17) is a pro-inflammatory cytokine secreted by activated T-cells. Recently discovered related molecules are forming a family of cytokines, the IL-17 family. The prototype member of the family has been designated IL-17A. Due to recent advances in the human genome sequencing and proteomics five additional members have been identified ...
Dominik R. Haudenschild +3 more
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Regulation of Interleukin-17 Production
2016Innate immunity represents the first line of host defense against extracellular infections. Timely initiation of inflammatory responses to invading pathogens confers host the ability to prevent, restrict, and eliminate microorganisms and further trigger adaptive immunity to provide extended eradication of the pathogens as well as long-term protection ...
Xiaojing Ma, Wenjuan Dong
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Coronary Artery Disease, 2006
Atherosclerosis is a chronic inflammatory disease and interleukins are considered to play a key role in the chronic vascular inflammatory response that is typical of atherosclerosis. The serum levels of several of these cytokines have been found to positively correlate with coronary arterial disease and its sequelae.The aim of our study was to evaluate
Hashmi, Satwat, Zeng, Qiu Tang
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Atherosclerosis is a chronic inflammatory disease and interleukins are considered to play a key role in the chronic vascular inflammatory response that is typical of atherosclerosis. The serum levels of several of these cytokines have been found to positively correlate with coronary arterial disease and its sequelae.The aim of our study was to evaluate
Hashmi, Satwat, Zeng, Qiu Tang
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Interleukin-17 and Type 17 Helper T Cells
New England Journal of Medicine, 2009Type 17 helper T cells (Th17) — a third class of T cells — and their major cytokine, interleukin-17, are essential for the defense against certain fungi, extracellular bacteria, and Mycobacterium tuberculosis. Defective control of Th17 cells and production of interleukin-17 are prominent in chronic inflammation and several immunoinflammatory disorders.
Vijay K. Kuchroo +2 more
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Interleukin-17 and the interleukin-17 family member network.
Allergy and asthma proceedings, 2004Interleukin-17 (now known as IL-17A), is a homodimer of two 155 amino acid chains secreted by CD4+ activated memory T cells (CD45+ RO+) and is available as a glycosylated 20- to 30-kDa homodimeric peptide. Human IL-17 shows amino acid sequence identity of 62.5 and 58% to the mouse and rat sequences, respectively.
HUANG SH +14 more
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Interleukin-17 and interleukin-23 in patients with polymyositis and dermatomyositis
Scandinavian Journal of Rheumatology, 2011To analyse the concentration of interleukin (IL)-17 and IL-23 in serum and ex vivo culture supernatant of peripheral blood mononuclear cells (PBMCs) from patients with polymyositis (PM) and dermatomyositis (DM) compared with healthy controls (HC).Enzyme-linked immunosorbent assay (ELISA) was used to analyse the concentration of IL-17 and IL-23 from 25 ...
Weiguo Xiao +3 more
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