Results 381 to 390 of about 4,008,604 (402)
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Psoriasis: rationale for targeting interleukin-17
British Journal of Dermatology, 2012The exact pathogenesis of plaque psoriasis remains to be fully determined, but it is thought to depend on environmental and genetic factors that stimulate dysregulated innate and adaptive immune responses in the skin. The cytokine interleukin (IL)-17A plays a key role in host defence against extracellular bacteria and fungi.
GIROLOMONI, Giampiero +2 more
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Interleukin-17 in post-stroke neurodegeneration
Neuroscience & Biobehavioral Reviews, 2013Stroke is a leading cause of physical disability with neurodegenerative sequelae such as dementia and depression causing significant excess morbidity. Stroke severity can be exacerbated by apoptotic cell death in ischemic tissue, of which inflammatory activity is a key determinant.
Krista L. Lanctôt +6 more
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Interleukin-17: a mediator of inflammatory responses
Cellular and Molecular Life Sciences CMLS, 2004Interleukin-17 (IL-17) is a prototype member of a new cytokine family with six species identified to date. IL-17 is secreted mainly by activated CD4(+) and CD8(+) T lymphocytes, while its receptor is distributed ubiquitously. IL-17 has been classified as a proinflammatory cytokine because of its ability to induce the expression of many mediators of ...
Achim Jörres +2 more
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Interleukin-17 Antagonists in the Treatment of Psoriasis
Journal of Cutaneous Medicine and Surgery, 2015Background Psoriasis is a chronic, immune-mediated inflammatory skin disorder of unknown etiology. Interleukin (IL)-17a, a key product of the recently identified Th17 cell subset, has been found to play a critical role in the immunopathogenesis of psoriasis.
Jensen Yeung +1 more
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To Be 17 Again — Anti–Interleukin-17 Treatment for Psoriasis
New England Journal of Medicine, 2012Interleukin-17 is a cytokine that belongs to a family of six members (interleukins 17A through 17F), which bind a total of five receptors (interleukins 17RA through 17RE).1–3 Of these six interleukin-17 cytokines, interleukins 17A and 17F are very homologous and bind the same receptor complex (interleukins 17RA and 17RC).
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Interleukin-17 and fat: Timing is everything
ImmunityInterleukin-17 plays a major role in controlling adipose tissue homeostasis. In a recent study published in Nature, Douglas et al. demonstrate that time-of-day-dependent expression of interleukin-17 by tissue-resident innate lymphocytes in the adipose tissue drives circadian regulation of adipose tissue homeostasis and function.
Matthew C. Sinton +3 more
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Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells
Nature Immunology, 2007Eva Acosta-Rodriguez +7 more
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