Results 11 to 20 of about 898,035 (301)
Journal of Leukocyte Biology, 2003 Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses.
Gracie, J.A. +2 more
core +6 more sources
Interleukin 18 in the CNS [PDF]
Journal of Neuroinflammation, 2010 Interleukin (IL)-18 is a cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory ...
Sugama Shuei +3 more
doaj +5 more sources
Interleukin-18 and COVID-19. [PDF]
Epidemiol Infect, 2021 Abstract Vulnerability to coronavirus disease (COVID)-19 varies due to differences in interferon gamma (IFNγ) immunity. We investigated whether a key modifiable interferon precursor, interleukin-18, was related to COVID-19, overall and by severity, using Mendelian randomisation.
Schooling CM, Li M, Au Yeung SL.
europepmc +4 more sources
International Heart Journal, 2018 A prospective observational study was conducted to evaluate the predictive value of interleukin-18 (IL-18) for major adverse cardiovascular events (MACEs) in hemodialysis patients. A total of 85 participants (45 hemodialysis patients and 40 healthy volunteers) with a mean age of 56.3 years were enrolled in this study. Demographic and clinical data were
Shiying Wang +3 more
openaire +4 more sources
GSDMD contributes to myocardial reperfusion injury by regulating pyroptosis
Frontiers in Immunology, 2022 BackgroundGasdermin D (GSDMD) plays an essential role in the pathway of pyroptosis. However, whether GSDMD participates in myocardial ischaemia/reperfusion injury (MI/RI) remains poorly understood.MethodsSerum levels of GSDMD and IL-18 in ST-segment ...
Xiaomiao Ye +8 more
doaj +1 more source
Elevated levels of circulating IL-18BP and perturbed regulation of IL-18 in schizophrenia
Journal of Neuroinflammation, 2012 Background The pleiotropic pro-inflammatory cytokine Interleukin (IL)-18 has been proposed to play a role in schizophrenia, since elevated circulating levels of its protein and altered frequencies of genetic variants in its molecular system are reported ...
Palladino Ilaria +7 more
doaj +1 more source
Biomolecules, 2023 Pre-eclampsia is a harmful and potentially lethal medical condition during pregnancy clinically diagnosed by hypertension and commonly accompanied by proteinuria and multiorgan affections.
Luis M. Garcia-Puente +13 more
doaj +1 more source
Targeting interleukin 18 with interleukin 18 binding protein [PDF]
Annals of the Rheumatic Diseases, 2000 A novel, constitutively expressed and secreted interleukin 18 (IL18) binding protein (IL18BP) neutralises IL18. IL18BP shares many characteristics with soluble cytokine receptors of the IL1 family in that the protein exhibits specificity for IL18, belongs to the immunoglobulin-like class of receptors and has limited amino acid sequences with those of ...
openaire +2 more sources
cDNA Cloning of Biologically Active Chicken Interleukin-18 [PDF]
, 2000 By searching a chicken EST database, we identified a cDNA clone that appeared to contain the entire open reading frame (ORF) of chicken interleukin-18 (ChIL-18).
AHN H.-J. +13 more
core +1 more source
Engineered Tumor-Targeted T Cells Mediate Enhanced Anti-Tumor Efficacy Both Directly and through Activation of the Endogenous Immune System. [PDF]
, 2018 Chimeric antigen receptor (CAR) T cell therapy has proven clinically beneficial against B cell acute lymphoblastic leukemia and non-Hodgkin's lymphoma. However, suboptimal clinical outcomes have been associated with decreased expansion and persistence of
Avanzi, Mauro P +10 more
core +1 more source