Results 11 to 20 of about 63,552,420 (203)
Journal of Leukocyte Biology, 2003 Abstract Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses. IL-18 is expressed at sites of chronic inflammation, in autoimmune diseases, in a variety of cancers, and in the context of numerous infectious diseases.
Gracie, J.A. +2 more
core +6 more sources
Interleukin-18: Perspectives on the Newest Interleukin
Cytokine & Growth Factor Reviews, 1998 Just over two years ago the newest member of the interleukin family of cytokines, IL-18, was molecularly cloned. IL-18 was originally identified as a result of its ability to induce interferon gamma production, however with the advent of its cloning and the production of recombinant protein a number of other biological actions have since been ...
Gillespie, M T, Horwood, N J
core +6 more sources
Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis
Balkan Medical Journal, 2018 Background: Carotid artery stenosis is the atherosclerotic narrowing of the proximal internal carotid artery and one of the primary causes of stroke. Elevated expression of the pleiotropic proinflammatory cytokine interleukin-18 has been demonstrated in ...
Berk Arapi +6 more
doaj +2 more sources
Role of interleukin 15 and interleukin 18 in inflammatory response [PDF]
Annals of the Rheumatic Diseases, 2002 Interleukin 15 (IL15) and interleukin 18 (IL18) are cytokines produced principally by macrophages during innate immune response and subsequently profoundly influence adaptive immunity. Recent studies have shown that IL15 and IL18 play an influential part in inflammatory response. Here we present recent data mainly from our own laboratories illustrating
F Y, Liew, I B, McInnes
openaire +3 more sources
Interleukin-18 and COVID-19 [PDF]
Epidemiology and Infection, 2021 Abstract Vulnerability to coronavirus disease (COVID)-19 varies due to differences in interferon gamma (IFNγ) immunity. We investigated whether a key modifiable interferon precursor, interleukin-18, was related to COVID-19, overall and by severity, using Mendelian randomisation.
C. M. Schooling, M. Li, S. L. Au Yeung
openaire +2 more sources
International Heart Journal, 2018 A prospective observational study was conducted to evaluate the predictive value of interleukin-18 (IL-18) for major adverse cardiovascular events (MACEs) in hemodialysis patients. A total of 85 participants (45 hemodialysis patients and 40 healthy volunteers) with a mean age of 56.3 years were enrolled in this study. Demographic and clinical data were
Wang, Shiying +3 more
openaire +4 more sources
cDNA Cloning of Biologically Active Chicken Interleukin-18 [PDF]
, 2000 By searching a chicken EST database, we identified a cDNA clone that appeared to contain the entire open reading frame (ORF) of chicken interleukin-18 (ChIL-18).
Stäheli, Peter +15 more
core +1 more source
Elevated levels of circulating IL-18BP and perturbed regulation of IL-18 in schizophrenia
Journal of Neuroinflammation, 2012 Background The pleiotropic pro-inflammatory cytokine Interleukin (IL)-18 has been proposed to play a role in schizophrenia, since elevated circulating levels of its protein and altered frequencies of genetic variants in its molecular system are reported ...
Palladino Ilaria +7 more
doaj +1 more source
Targeting interleukin 18 with interleukin 18 binding protein [PDF]
Annals of the Rheumatic Diseases, 2000 A novel, constitutively expressed and secreted interleukin 18 (IL18) binding protein (IL18BP) neutralises IL18. IL18BP shares many characteristics with soluble cytokine receptors of the IL1 family in that the protein exhibits specificity for IL18, belongs to the immunoglobulin-like class of receptors and has limited amino acid sequences with those of ...
openaire +2 more sources
Distinct Roles of IL-1β and IL-18 in NLRC4-Induced Autoinflammation
Frontiers in Immunology, 2020 The NLRC4 inflammasome assembles in response to detection of bacterial invasion, and NLRC4 activation leads to the production of IL-1β and IL-18 together with pyroptosis-mediated cell death.
Yuki Sasaki +7 more
doaj +1 more source