Results 81 to 90 of about 595,005 (302)

Interleukin 18–independent engagement of interleukin 18 receptor-α is required for autoimmune inflammation [PDF]

Nature Immunology, 2006
T helper type 1 (T(H)1) lymphocytes are considered to be the main pathogenic cell type responsible for organ-specific autoimmune inflammation. As interleukin 18 (IL-18) is a cofactor with IL-12 in promoting T(H)1 cell development, we examined the function of IL-18 and its receptor, IL-18R, in autoimmune central nervous system inflammation.
Gutcher, I, Urich, E, Wolter, K, Prinz, M, Becher, B   +4 more
openaire   +5 more sources

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Long-term interleukin-6 levels and subsequent risk of coronary heart disease: Two new prospective studies and a systematic review [PDF]

, 2008
Background The relevance to coronary heart disease (CHD) of cytokines that govern inflammatory cascades, such as interleukin-6 (IL-6), may be underestimated because such mediators are short acting and prone to fluctuations.
Kaptoge Stephen, Kaptoge, S., Lennon, L., Danesh, J, Lucy Lennon, Gudnason, Vilmundur, Stephen Kaptoge, Higgins Julian P. T, Wensley, F, Mann, Andrea G, Rumley, A., Sarwar, N, Wood, A, Ann Rumley, Vilmundur Gudnason, Danesh, J., Angleman, Sara B, Wood, A., Gudnason, V., Danesh John, Kaptoge, S, Wensley Frances, Wood, Angela, Lowe, G.D., John Danesh, Eiriksdottir, Gudny, Rumley, Ann, Angleman Sara B, Wensley, Frances, Gudnason Vilmundur, Sara B Angleman, Whincup Peter H, Kaptoge, Stephen, Gordon D O Lowe, Lennon Lucy, Sarwar, Nadeem, Higgins, JPT, Lennon, L, Higgins, J.P.T., Andrea G Mann, Peter H Whincup, Mann, AG, Lowe, GDO, Whincup, PH, Mann Andrea G, Whincup, P.H., Julian P T Higgins, Higgins, Julian PT, Lowe, Gordon DO, Angleman, S.B., Wensley, F., Sarwar, N., Mann, A.G., Eiriksdottir, G, Higgins, JP, Danesh, John, Sarwar Nadeem, Gudnason, V, Angleman, SB, Eiriksdottir, G., Lowe Gordon D. O, Angela Wood, Frances Wensley, Lowe, GD, Whincup, Peter H, Nadeem Sarwar, Eiriksdottir Gudny, Gudny Eiriksdottir, Wood Angela, Lennon, Lucy, Rumley Ann, Rumley, A   +71 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Association between IL-18 and IL-18bp Levels and Chronic Urticaria in Sulfur Mustard Exposed Veterans

طب جانباز, 2014
Aims: Exposure to mustard gas leads to acute and chronic toxic effects on the skin. Results from several studies have been suggested the role of immune mediators, including Interleukin-18, in the pathogenesis of diseases associated with the urticaria ...
N. Askari, T. Ghazanfari, J. Shohreh, M.R. Soroush, S.M. Davoudi   +4 more
doaj  

Increased Interleukin 18-Dependent Immune Responses Are Associated With Myopericarditis After COVID-19 mRNA Vaccination

Frontiers in Immunology, 2022
Myocarditis and myopericarditis may occur after COVID-19 vaccination with an incidence of two to twenty cases per 100,000 individuals, but underlying mechanisms related to disease onset and progression remain unclear.
Taejoon Won, Nisha Aggarwal Gilotra, Megan Kay Wood, David Matthew Hughes, Monica Vladut Talor, Jana Lovell, Aaron Michael Milstone, Charles Steenbergen, Daniela Čiháková, Daniela Čiháková   +9 more
doaj   +1 more source

Balance between Interleukin-18 and Interleukin-18 binding protein in auto-inflammatory diseases

Cytokine, 2022
Interleukin (IL)-18 is a member of the IL-1 family of cytokines with pleiotropic and potent pro-inflammatory activities that are tightly controlled at the level of production and in the extracellular space. Indeed, IL-18 is translated as a leaderless biologically inert pro-peptide that is cleaved by caspase-1 in its N-terminus domain to become active ...
Mathilde Harel, Sébastien Fauteux-Daniel, Charlotte Girard-Guyonvarc'h, Cem Gabay   +3 more
openaire   +2 more sources

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Diagnostic value of serum levels of interleukin-9,interleukin-18 and interleukin-32 in patients with multiple myeloma

Linchuang shenzangbing zazhi, 2021
Objective To explore the serum expressions of interleukin-9（IL-9）,interleukin-18（IL-18）and interleukin-32（IL-32）in patients with multiple myeloma（MM）and examine their values in predicting renal injury.Methods Seventy-eight MM patients from January 2015 ...
Zhuang Ni-la, Zhan Wen-li, Mo Tai-jin, Li Xiao-gan, Zeng Xiang-xing, Wang Qiu-xiang   +5 more
doaj  

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source