Results 1 to 10 of about 238,614 (342)

The interleukin-1 receptor antagonist influences interleukin-1 effects in rat and mouse [PDF]

Mediators of Inflammation, 1992
In this work we have focused on the ability of interleukin-1 to induce an acute phase protein response and a degranulation of polymorphonuclear leukocytes in vivo.
Bjrök, P., Ohlsson, K.
core   +8 more sources

Human interleukin-1 receptor antagonist is expressed in liver [PDF]

FEBS Letters, 1992
Using PCR and Northern blot analysis, an IL-1 receptor antagonist specific transcript was amplified from HepG2- and liver mRNA, cDNA clones coding for IL-1 receptor antagonist were isolated from a liver cDNA library and sequence comparison revealed ...
Estaller, C., Sim, Robert B., Steinkasserer, Alexander, Weiss, Elisabeth H.   +3 more
core   +6 more sources

Fetal skin as a pro-inflammatory organ: Evidence from a primate model of chorioamnionitis. [PDF]

PLoS ONE, 2017
BackgroundIntrauterine infection is a primary cause of preterm birth and fetal injury. The pro-inflammatory role of the fetal skin in the setting of intrauterine infection remains poorly characterized. Whether or not inflammation of the fetal skin occurs
Boonkasidecha, Suppawat, Jobe, Alan H, Kallapur, Suhas G, Kannan, Paranthaman Senthamarai, Kemp, Matthew W   +4 more
core   +11 more sources

Interleukin-1 Receptor antagonist Production by Human Keratinocytes [PDF]

Journal of Investigative Dermatology, 1992
Human keratinocytes produce biologically active pro–IL-Iα and inactive pro-IL-1β with most protein remaining intracellular. IL-1 receptor antagonist (IL-1ra) is a newly described member of the IL-1 family that is secreted by stimulated monocytes and ...
Arend, William P, Bigler, Carl F, Norris, David A, Weston, William L   +3 more
core   +4 more sources

Interleukin Expression after Injury and the Effects of Interleukin-1 Receptor Antagonist [PDF]

PLoS ONE, 2013
Ligament healing follows a series of complex coordinated events involving various cell types, cytokines, as well as other factors, producing a mechanically inferior tissue more scar-like than native tissue. Macrophages provide an ongoing source of cytokines to modulate inflammatory cell adhesion and migration as well as fibroblast proliferation ...
Connie S. Chamberlain, Ellen M. Leiferman, Ray Vanderby, Geoffrey S. Baer, Kayt E. Frisch, William L. Murphy, Stacey Brickson   +6 more
openaire   +6 more sources

Interleukin-1 receptors and receptor antagonist in haemodialysis [PDF]

Nephrology Dialysis Transplantation, 1997
Biological activity of interleukin-1 (IL-1) depends on the number and type of IL-1 receptors on target cells and on the amounts of its naturally occurring inhibitor, the IL-1 receptor antagonist (IL-1ra).Expression of IL-1 receptor was studied on the peripheral blood mononuclear cells of 20 end-stage renal-disease patients maintained by chronic ...
DONATI D., DEGIANNIS D., MAZZOLA E., GASTALDI L., RASKOVA J., RASKA K., CAMUSSI, Giovanni   +6 more
openaire   +4 more sources

IL-1Ra Protects Hepatocytes from CCl4-Induced Hepatocellular Apoptosis via Activating the ERK1/2 Pathway

Pharmaceutical Fronts, 2020
Interleukin-1 receptor antagonist is an important acute-phase protein and an immune mediator, and its expression is associated with the development of hepatitis or acute liver failure.
Ying Zheng, Xinyi Xiao, Zhuoyi Yang, Meiqi Zhou, Hui Chen, Siyi Bai, Jianwei Zhu, Yunsheng Yuan   +7 more
doaj   +1 more source

Inflammatory Biomarkers Are Associated With a Decline in Functional Status at Discharge in Children With Acute Respiratory Failure: An Exploratory Analysis

Critical Care Explorations, 2021
OBJECTIVES:. To evaluate the link between early acute respiratory failure and functional morbidity in survivors using the plasma biomarkers interleukin-8, interleukin-1 receptor antagonist, thrombomodulin, and plasminogen activator inhibitor-1.
Erin F. Carlton, MD, MSc, Heidi M. Weeks, PhD, Mary K. Dahmer, PhD, Michael W. Quasney, MD, PhD, Anil Sapru, MD, MAS, Martha A.Q. Curley, PhD, RN, Heidi R. Flori, MD, for the BALI and RESTORE Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Heidi Flori, Michael W. Quasney, Mary K. Dahmer, Anil Sapru, Martha Curley, Michael A. Matthay, Scot T. Bateman, M. D. Berg, Santiago Borasino, G. Kris Bysani, Allison S. Cowl, Cindy Darnell Bowens, E. Vincent S. Faustino, Lori D. Fineman, A. J. Godshall, Ellie Hirshberg, Aileen L. Kirby, Gwenn E. McLaughlin, Shivanand Medar, Phineas P. Oren, James B. Schneider, Adam J. Schwarz, Thomas P. Shanley, Lauren R. Source, Edward J. Truemper, Michele A. Vander Heyden, Kim Wittmayer, Athena Zuppa, David Wypij, Martha A. Q. Curley, David Wypij, Geoffrey L. Allen, Derek C. Angus, Lisa A. Asaro, Judy A. Ascenzi, Scot T. Bateman, Santiago Borasino, Cindy Darnell Bowens, G. Kris Bysani, Ira M. Cheifetz, Allison S. Cowl, Brenda L. Dodson, E. Vincent S. Faustino, Lori D. Fineman, Heidi R. Flori, Linda S. Franck, Rainer G. Gedeit, Mary Jo C. Grant, Andrea L. Harabin, Catherine Haskins-Kiefer, James H. Hertzog, Larissa Hutchins, Aileen L. Kirby, Ruth M. Lebet, Michael A. Matthay, Gwenn E. McLaughlin, JoAnne E. Natale, Phineas P. Oren, Nagendra Polavarapu, James B. Schneider, Adam J. Schwarz, Thomas P. Shanley, Shari Simone, Lewis P. Singer, Lauren R. Source, Edward J. Truemper, Michele A. Vander Heyden, R. Scott Watson, Claire R. Wells   +76 more
doaj   +1 more source

Serum interleukin-6, interleukin-8, and interleukin-1 receptor antagonist levels in South Indian fibromyalgia patients and its correlation with disease severity

Indian Journal of Rheumatology, 2021
Background: Fibromyalgia is a chronic pain syndrome characterized by widespread diffuse pain and multiple tender points along with sleep disturbances, fatigue, and psychological distress.
Sandeep Surendran, C B Mithun, Vishnu S Chandran, Suma Balan, Arun Tiwari   +4 more
doaj   +1 more source

Disease Activity Is More Associated with IL-1 Than with IL-6 in Patients with Rheumatoid Arthritis

Life, 2022
Interleukin-1 receptor antagonist (IL-1ra) concentration reflects and is proportional to IL-1 production. Both IL-1 and IL-6 are involved in the pathogenesis of rheumatoid arthritis (RA).
Cristina Almeida-Santiago, Juan Carlos Quevedo-Abeledo, María Vanesa Hernández-Hernández, Antonia de Vera-González, Alejandra González-Delgado, Miguel Ángel González-Gay, Iván Ferraz-Amaro   +6 more
doaj   +1 more source