Results 161 to 170 of about 238,614 (342)

Rational Design of Inner Ear Drug Delivery Systems

Advanced Science, EarlyView.
Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu, Zhiyan Xuan, Haoyu Ren, Keng Chen, Hui Zhang, Huan Wang   +5 more
wiley   +1 more source

Cloning and characterization of a new isoform of the interleukin 1 receptor antagonist. [PDF]

, 1995
Marta Muzio, Nadia Polentarutti, Marina Sironi, Guido Poli, Luca De Gioia, Martino Introna, Alberto Mantovani, Francesco Colotta   +7 more
openalex   +1 more source

SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist in Ischemic Stroke): A Randomized Controlled Phase 2 Trial

Stroke, 2018
Craig J. Smith, S. Hulme, A. Vail, C. Heal, A. Parry-Jones, S. Scarth, Karen Hopkins, M. Hoadley, S. Allan, N. Rothwell, S. Hopkins, P. Tyrrell   +11 more
semanticscholar   +1 more source

Accurate Transcription Factor Activity Inference to Decipher Cell Identity from Single‐Cell Transcriptomic Data with MetaTF

Advanced Science, EarlyView.
MetaTF is a new computational framework that uses single‐cell RNA sequencing (scRNA‐seq) data to infer transcription factor activity with the aim to help in deciphering cells identity starting from a heterogeneous population, and apply it to characterize mouse hematopoietic stem cells and breast cancer epithelial cells, thus identifying a novel subset ...
Yongfei Hu, Yuanyuan Zhu, Guangjue Tang, Ming Shan, Puwen Tan, Ying Yi, Xiyuan Zhang, Man Liu, Xinyu Li, Le Wu, Jia Chen, Hailong Zheng, Yan Huang, Zhuan Li, Xiaobo Li, Dong Wang   +15 more
wiley   +1 more source

Inhibition of Interleukin-1-Induced Effects in Synoviocytes Transduced with the Human IL-1 Receptor Antagonist cDNA Using an Adenoviral Vector [PDF]

, 1995
Blake J. Roessler, John W. Hartman, David K. Vallance, Jill M. Latta, Sonia L. Janich, Beverly L. Davidson   +5 more
openalex   +1 more source

β‐Glucuronidase‐Expressing Lactobacillus reuteri Triggers Irinotecan Enterotoxicity Through Depleting the Regenerative Epithelial Stem/Progenitor Pool

Advanced Science, EarlyView.
XLP mitigated CPT11 mucositis by suppressing GUS‐expressing microbes, notably L. reuteri, and diminishing bacterial GUS activity, consequently reducing SN38 accumulation to protect the intestinal epithelium. This preservation of the mucosal stem cell niche enabled rapid regeneration of secretory lineages such as mucin‐producing goblet cells, which ...
Bei Yue, Ruiyang Gao, Ling Zhao, Donghui Liu, Cheng Lv, Ziyi Wang, Fangbin Ai, Beibei Zhang, Zhilun Yu, Xiaolong Geng, Hao Wang, Kang Wang, Kaixian Chen, Chenghai Liu, Zhengtao Wang, Wei Dou   +15 more
wiley   +1 more source

Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study. [PDF]

, 2019
BackgroundEnrichment strategies improve therapeutic targeting and trial efficiency, but enrichment factors for sepsis trials are lacking. We determined whether concentrations of soluble tumor necrosis factor receptor-1 (sTNFR1), interleukin-8 (IL8), and ...
Abbott, Jason, Anderson, Brian J, Bayliffe, Andrew I, Belzer, Annika, Calfee, Carolyn S, Christie, Jason D, Deiss, Thomas, Dunn, Thomas G, Gallop, Robert J, Jauregui, Alejandra, Johansson, Erik, Kangelaris, Kirsten N, Lazaar, Aili L, Liu, Kathleen D, Matthay, Michael A, Meyer, Nuala J, Miano, Todd A, Reilly, John P, Shashaty, Michael GS, Vessel, Kathryn, Zhuo, Hanjing   +20 more
core  

HIC1 suppresses Tumor Progression and Enhances CD8+ T Cells Infiltration Through Promoting GSDMD‐induced Pyroptosis in Gastric Cancer

Advanced Science, EarlyView.
These findings elucidate the innovative role of HIC1 as a transcriptional activator in GC, driving the initiation of pyroptosis and enhancing CD8+ T cell infiltration, which has certain novelty and creative significance. Collectively, targeting HIC1 can present an appealing immunotherapeutic strategy to improve outcomes in GC patients.
Mengjie Kang, Wenqi Du, Lina Ding, Mengdi Wu, Dongsheng Pei   +4 more
wiley   +1 more source

Interleukin (IL) 1β, IL-1 receptor antagonist, IL-10, and IL-13 gene expression in the central nervous system and anterior pituitary during systemic inflammation: Pathophysiological implications [PDF]

, 1997
Ma‐Li Wong, Peter B. Bongiorno, Valéria Rettori, Samuel M. McCann, Júlio Licinio   +4 more
openalex   +1 more source

IL-1 receptor antagonist production by isolated mononuclear cells is a better indicator of bioincompatibility of hemodialysis membranes than that by stimulated whole blood [PDF]

, 2000
Eigler, A., Endres, S., Schiffl, Helmut, Toepfer, Marcel, Tuma, E.   +4 more
core   +1 more source