Results 211 to 220 of about 167,720 (353)

In vitro production of interleukin-1 receptor antagonist in chronic renal failure, CAPD and HD

, 1992
Brian J.G. Pereira, Debra D. Poutsiaka, Andrew J. King, James A. Strom, G.R. Narayan, Andrew S. Levey, C A Dinarello   +6 more
openalex   +1 more source

Interleukin-1 receptor antagonist ameliorates the pain hypersensitivity, spinal inflammation and oxidative stress induced by systemic lipopolysaccharide in neonatal rats

, 2020
Cheng-Ta Hsieh, Yih‐Jing Lee, Jonathan W. Lee, Silu Lu, Michelle Tucci, Xiaoli Dai, Norma B. Ojeda, Hyun Joon Lee, Lir‐Wan Fan, Lu‐Tai Tien   +9 more
openalex   +2 more sources

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Interleukin-1 Receptor Antagonist as a Potential Mediator Linking Psoriasis and Non-Alcoholic Fatty Liver Disease: Insights From Mendelian Randomization and Experimental Evidence. [PDF]

Clin Cosmet Investig Dermatol
Shuai C, Cheung S, Zhang L, Cao H, Yuan Y, Ge Q, Wang Y, Li X, Zheng J, Xue F.   +9 more
europepmc   +1 more source

Autoantibodies against interleukin-1 receptor antagonist in multisystem inflammatory syndrome in children: a multicentre, retrospective, cohort study. [PDF]

Lancet Rheumatol, 2022
Pfeifer J, Thurner B, Kessel C, Fadle N, Kheiroddin P, Regitz E, Hoffmann MC, Kos IA, Preuss KD, Fischer Y, Roemer K, Lohse S, Heyne K, Detemple MC, Fedlmeier M, Juenger H, Sauer H, Meyer S, Rohrer T, Wittkowski H, Becker SL, Masjosthusmann K, Bals R, Gerling S, Smola S, Bewarder M, Birk E, Keren A, Böhm M, Jakob A, Abdul-Khaliq H, Anton J, Kabesch M, Pino-Ramirez RM, Foell D, Thurner L.   +35 more
europepmc   +1 more source

Bimetallic Peroxide Nanocomposites‐Driven Redox Dyshomeostasis to Activate Sequential Cuproptosis and Pyroptosis for Amplified Tumor Immunotherapy

Advanced Science, EarlyView.
Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He, Haixia Zhu, Peipei Kang, Lili Feng, Chenghao Yu, Yanlin Zhu, Bin Liu, Zhengxiao Guo, Piaoping Yang   +8 more
wiley   +1 more source

The Activity of Protectin DX, 17 HDHA and Leukotriene B4 Is Correlated with Interleukin-1β (IL-1β) and Interleukin-1 Receptor Antagonist (IL-1Ra) in the Early Subacute Phase of Stroke. [PDF]

Int J Mol Sci
Kotlega D, Drozd A, Zembron-Lacny A, Morawin B, Ryterska K, Szczuko M.   +5 more
europepmc   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Correction: Interleukin-1 receptor antagonist overexpression in mesenchymal stem cells improves hemorrhagic cystitis outcomes via HtrA serine peptidase 3. [PDF]

Stem Cell Res Ther
Song J, Han Y, Chen Y, Cheng L, Xiao J, Li A, Kong D, Jiang Y, Zheng C.   +8 more
europepmc   +1 more source

IL-1 receptor antagonist attenuates proinflammatory responses to rhinovirus in airway epithelium. [PDF]

J Allergy Clin Immunol, 2023
Schworer SA, Chason KD, Chen G, Chen J, Zhou H, Burbank AJ, Kesic MJ, Hernandez ML.   +7 more
europepmc   +1 more source