Results 291 to 300 of about 238,614 (342)

Interleukin‐1 receptor antagonist in the fetomaternal compartment

Acta Paediatrica, 1995
Interleukin‐1 (IL‐1) is a major mediator in infections and inflammation. Interleukin‐1 receptor antagonist (IL‐1ra) opposes the actions of IL‐1. IL‐1ra is present in exceptionally high concentrations in third trimester amniotic fluid. We studied IL‐1ra in amniotic fluid, fetal serum and newborn urine.
Urpo Lappalainen, Kristina Bry, Feizal Waffarn, K Teramo, Mikko Hallman   +4 more
openaire   +3 more sources

Disease‐Modifying Osteoarthritis Treatment With Interleukin‐1 Receptor Antagonist Gene Therapy in Small and Large Animal Models

Arthritis & Rheumatology, 2018
Gene therapy holds great promise for the treatment of osteoarthritis (OA) because a single intraarticular injection can lead to long‐term expression of therapeutic proteins within the joint.
A. Nixon, Matthew W. Grol, Hayley M. Lang, M. Z. Ruan, A. Stone, L. Begum, Yuqing Chen, B. Dawson, F. Gannon, S. Plutizki, Brendan H. Lee, K. Guse   +11 more
semanticscholar   +1 more source

Expression of interleukin-1 and interleukin-1 receptor antagonists in endometrial cancer

Gynecologic Oncology, 1991
The cytokine interleukin-1 (IL-1) can inhibit growth of breast cancer cells in culture and promote cellular differentiation in synergism with other growth factors. A secreted IL-1 receptor antagonist (sIL-1ra) has been described and an intracellular version (icIL-1ra) has been cloned; both antagonists block IL-1-dependent responses.
W.C. Fowler, W.C. Fowler, Glenn J. Jaffe, Glenn J. Jaffe, Stephen Haskill, Stephen Haskill, Linda Van Le, Linda Van Le   +7 more
openaire   +3 more sources

Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group.

Critical Care Medicine, 1997
OBJECTIVE To determine the therapeutic efficacy and safety of recombinant human interleukin-1 receptor antagonist (rhIL-1ra) in the treatment of patients with severe sepsis.
S. Opal, C. Fisher, J. Dhainaut, J. Vincent, R. Brase, S. Lowry, J. Sadoff, G. Slotman, H. Levy, R. Balk, M. Shelly, J. Pribble, J. Labrecque, J. Lookabaugh, H. Donovan, H. Dubin, R. Baughman, J. Norman, E. DeMaria, K. Matzel, E. Abraham, M. Seneff   +21 more
semanticscholar   +1 more source

Interleukin‐1 and interleukin‐1 receptor antagonist in inflammatory bowel disease.

Alimentary Pharmacology & Therapeutics, 1996
Ulcerative colitis (UC) and Crohn's disease (CD) are immunologically mediated disorders characterized by a chronic, relapsing inflammatory response. Elevation of several cytokines, with important immunoregulatory and proinflammatory activities have been demonstrated during active inflammatory bowel disease (IBD).
Theresa T. Pizarro, Fabio Cominelli
openaire   +2 more sources

Febrile Seizures: Interleukin 1β and Interleukin-1 Receptor Antagonist Polymorphisms

Pediatric Neurology, 2009
In order to investigate the association between IL-1beta -511 C-->T and IL-1 receptor antagonist intron 2 variable tandem repeat polymorphisms, and febrile seizures in children, 90 children (mean age, 19.7 +/- 11.2 months) diagnosed with febrile seizure and 106 healthy controls (mean age, 14.2 +/- 3.6 months) with no seizure or neurologic events were ...
Serdaroglu G., Alpman A., Tosun A., Pehlivan S., Özkınay F., Tekgül H., Gökben S.   +6 more
openaire   +4 more sources

lnterleukin-1 Receptor Antagonist

Critical Reviews™ in Immunology, 1995
The interleukin-1 receptor antagonist (IL-1ra) is unusual in that it is the only known naturally occurring, cytokine receptor antagonist with no apparent agonist function. Over the last 5 years, since the cloning of the IL-1ra cDNA sequence, there has been intensive research on the genetics, regulation, and potential therapeutic value of this protein ...
openaire   +5 more sources

Localisation of mRNA for interleukin-1 receptor and interleukin-1 receptor antagonist in the rat ovary

Journal of Endocrinology, 1997
Abstract Interleukin-1 (IL-1) is a multifunctional cytokine with profound effects on ovarian function. The effects of IL-1 on ovarian steroidogenesis have been demonstrated in several species. IL-1 mRNA levels are increased in the thecal layer of the ovulating follicle and IL-1β has been shown to induce ovulations in vitro.
Simon Maddocks, A. P. Simula, Ronald P. Hart, K. H. Cui, Mats Brännström, Mats Brännström, Robert J. Norman, Lingjia Wang   +7 more
openaire   +4 more sources

Recombinant Human Interleukin 1 Receptor Antagonist in the Treatment of Patients With Sepsis Syndrome: Results From a Randomized, Double-blind, Placebo-Controlled Trial

, 1994
Objective. —To further define the safety and efficacy of recombinant human interleukin 1 receptor antagonist (rhIL-1ra) in the treatment of sepsis syndrome. Study Design.
C. Fisher, J. Dhainaut, S. Opal, J. Pribble, R. Balk, G. Slotman, T. J. Iberti, E. Rackow, M. Shapiro, R. Greenman, H. Reines, M. Shelly, B. Thompson, J. Labrecque, M. Catalano, W. Knaus, J. Sadoff, M. Astiz, C. Carpati, R. Bone, B. Friedman, A. J. Mure, C. Brathwaite, E. Shapiro, L. Melhorn, Robert W. Taylor, M. Keegan, Jacklyn O’Brien, R. Schein, M. Pena, Monina Wasserlouf, J. Oropello, E. Benjamin, R. Delguidice, G. Emmanuel, T. Lie, L. Anderson, J. Marshall, W. D. Majo, O. Rotstein, D. Foster, E. Abraham, H. Middleton, C. Perry, H. Levy, D. Fry, S. Simpson, R. Crowell, M. Neidhart, D. Stevens, T. Coffman, Nagraj Narasimhan, D. K. Merrick, W. Bergquist, K. Matzel, M. Huebler, G. Foulke, T. Albertson, W. Walby, R. Allen, R. Baughman, P. Hasselgren, M. Fink, F. Favorito, B. Thompson, R. Corbin, G. Y. Shellhorse, A. Frazier, S. White, C. Garrard, C. A'Court, S. Storer, D. Gervich, Debra Foshe, R. Brase, A. Bagdahn, R. Cooney, J. S. Smith, Louis F. Martin, J. Vincent, G. Friedman, G. Berlot, J. Fletcher, Mark D. Williams, T. Wright, Steven C. Johnson, Carinda Feild, K. Wolf, N. MacIntyre, H. Dubin, M. Durkin, Penelope K. Dubin, K. Staubach, A. Fein, D. Schulman, M. Niederman, D. Chalfin, P. A. Van, Leeuwen, M. Boermeester, A. J. Schneider, J. Bander, Amy Imm, G. Bernard, L. Nelson, M. Stroud, K. Safcsak, F. Cerra, J. Rindal, Henry Mann, N. Halpern, J. Silverstein, M. Alicea, W. Sibbald, Claudio M. Martin, F. Rutledge, K. Petti, J. Russell, Robert Kruger, Alana Drummond, P. Lange, T. Seifert, A. Durocher, A. Tenaillon, R. Boiteau, T. Lherm, S. Lowry, S. Coyle, P. Barie, E. DeMaria, D. Snydman, S. Schwaitzberg, S. Nasraway, J. Grindlinger, W. Summer, Benjamen de Boisblanc, M. Wahl, K. Alestig, J. Grossman, D. Maki, H. Paz, M. Weiner, D. Bihari, David Campbell, G. Bleichner, M. Dahn, M. Lange, Jesse B. Hall, A. Pohlman, R. Wenzel, M. Grosserode, M. Costigan, W. Mileski, J. Weigelt, N. Yeston, Cheryl Irizarry, J. Ross, J. Robbins, P. Nightingale, K. Owen, S. Sandstedt, S. Berg, G. Simon, M. Seneff, K. Conry, J. Zimmerman, R. Dellinger, R. F. Johnston, Patricia Allee, P. Grande, E. Myhre, J. Dhainaut, I. Hamy, J. Mira, J. Harmon, Jon C. White, L. Mckie, H. Silverman, Pamela Tuma, D. Bennett, J. Porter, M. Laurell, S. Jacobs, S. Ash, D. Stiles, M. Prior, G. Knatterud, M. Terrin, J. Kufera, Patricia Wilkens, Knut Ra, L. Monroe, C. Sprung, C. M. Hamilton, R. Matthay, W. McCabe, J. Tonascia, H. Wiedeman, J. Wittes, G. Campion, C. R. Croft, Richard Lustick, J. Lookabaugh, G. Gordon, L. Noe, D. Bloedow, Smith Christopher, Dennis Brannon, R. Kush, D. Ng, E. Moore, Karen Bazemore, M. Galvan, D. Wagner, F. Harrell, D. Stablein   +215 more
semanticscholar   +1 more source

Interleukin‐6 and interleukin‐1 receptor antagonist in acute stroke

Annals of Neurology, 1995
AbstractElevated plasma levels of interleukin‐6 (IL‐6), a key regulator of the acute phase response that includes increased fibrinogen synthesis, have recently been detected in patients with acute stroke. Nevertheless, the role of the acute phase response in stroke has been controversial, with some studies suggesting that preexisting infection accounts
J. Samantha Hazel, Wayne M. Clark, Jenny R. Silberger, Bruce M. Coull, Bruce M. Coull, Nancy B. Beamer, Nancy B. Beamer   +6 more
openaire   +3 more sources