Results 261 to 270 of about 149,441 (296)

Counteracting corneal immunoinflammatory lesion with interleukin-1 receptor antagonist protein

Journal of Leukocyte Biology, 2004
AbstractHerpetic stromal keratitis (HSK) is a T cell-orchestrated, immunoinflammatory lesion that results from corneal Herpes simplex virus infection. Previous reports indicate an essential role for proinflammatory cytokine interleukin (IL)-1 in HSK pathogenesis.
Partha Sarathi, Biswas, Kaustuv, Banerjee, Mei, Zheng, Barry T, Rouse   +3 more
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Interleukin-1 Receptor Antagonist Protein and mRNA in the Rat Adrenal Gland

Journal of Interferon & Cytokine Research, 1995
The occurrence of the endogenous receptor antagonist for the cytokine interleukin-1 in the rat adrenal gland was analyzed y polymerase chain reaction and by immunohistochemistry using a rabbit polyclonal antiserum. Expression of interleukin-1 receptor antagonist mRNA was demonstrated in both adrenal medulla and cortex, and a marked increase in the ...
M, Schultzberg, S, Tingsborg, S, Nobel, J, Lundkvist, S, Svenson, A, Simoncsits, T, Bartfai   +6 more
openaire   +2 more sources

The mouse interleukin 1 receptor antagonist protein: gene structure and regulation in vitro

Cytokine, 1994
The interleukin 1 receptor antagonist (IL-1ra) protein is an inhibitor of the pro-inflammatory cytokine interleukin 1. We have sequenced the mouse gene encoding the monocyte form of IL-1ra (IL-1rn) and compared it with the sequence of the human homologue.
K A, Zahedi, C M, Uhlar, M, Rits, A E, Prada, A S, Whitehead   +4 more
openaire   +2 more sources

Interleukin-1 receptor antagonist prevents sepsis-induced inhibition of protein synthesis

American Journal of Physiology-Endocrinology and Metabolism, 1994
To understand the role of interleukin-1 (IL-1) as a mediator of the sepsis-induced skeletal muscle catabolism, we investigated the effects of a specific IL-1 receptor antagonist (IL-1ra) on skeletal muscle protein metabolism in a rodent model of chronic abdominal sepsis.
R, Cooney, E, Owens, C, Jurasinski, K, Gray, J, Vannice, T, Vary   +5 more
openaire   +2 more sources

Initial crystallographic analysis of a recombinant human interleukin-1 receptor antagonist protein

Acta Crystallographica Section D Biological Crystallography, 1994
We report the crystallization of samples of a recombinant preparation of human interleukin-1 receptor antagonist protein (IRAP) and solution of the crystal structure by isomorphous replacement methods. Crystals were obtained by the hanging-drop vapor-diffusion method at 277 K from solutions of PEG 4000 containing sodium chloride, dithiothreitol and ...
L L, Clancy, B C, Finzel, A W, Yem, M R, Deibel, N A, Strakalaitis, D P, Brunner, R M, Sweet, H M, Einspahr   +7 more
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Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein

Nature, 1990
A human myelomonocytic cell line, U937, produced an interleukin-1 (IL-1) receptor antagonist protein (IRAP) which was purified and partially sequenced. A complementary DNA coding for IRAP was cloned and sequenced. The mature translation product of the cDNA has been expressed in Escherichia coli and was an active competitive inhibitor of the binding of ...
D. B. Carter, M. R. Deibel, C. J. Dunn, C.-S. C. Tomich, A. L. Laborde, J. L. Slightom, A. E. Berger, M. J. Bienkowski, F. F. Sun, R. N. McEwan, P. K. W. Harris, A. W. Yem, G. A. Waszak, J. G. Chosay, L. C. Sieu, M. M. Hardee, H. A. Zurcher-Neely, I. M. Reardon, R. L. Heinrikson, S. E. Truesdell, J. A. Shelly, T. E. Eessalu, B. M. Taylor, D. E. Tracey   +23 more
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Cloning, heterologous expression and characterization of murine interleukin 1 receptor antagonist protein

European Journal of Immunology, 1991
AbstractA cDNA coding for the human interleukin 1 receptor antagonist protein (IL 1Ra) was used to clone the corresponding murine cDNA. The nucleotide sequence of the open reading frame coding for the processed form of mIL 1Ra predicted a 152‐residue protein that was 77% identical to human IL 1Ra.
M E, Shuck, T E, Eessalu, D E, Tracey, M J, Bienkowski   +3 more
openaire   +2 more sources

Potential agonist action of the interleukin-1 receptor antagonist protein: implications for treatment of women.

The Journal of Clinical Endocrinology & Metabolism, 1993
The interleukin-1 receptor antagonist protein (IRAP) caused a concentration-related increase in prostaglandin production by human decidual cells. The degree and time course of this stimulatory action were identical to those induced by interleukin 1 beta (IL-1 beta).
Mitchell, M.D., Edwin, S.S., Silver, R.M., Romero, R.J.   +3 more
openaire   +4 more sources

Genetic Regulation and Activities of an Interleukin 1 Receptor Antagonist Protein

1993
Publisher Summary The cytokine interleukin 1 (IL-1) plays an important role in the response to infection and injury. IL-1 can have positive effects on events in the immune response, including T, B, and natural killer (NK) cell activation. Glucocorticoids inhibit both the synthesis of IL-1 and its action on glucocorticoid-sensitive IL-1-responsive ...
Donald B. Carter, Ann E. Berger, Daniel E. Tracey   +2 more
openaire   +1 more source

Interleukin-1α and Interleukin-1β Stimulate Adrenocorticotropin Secretion in the Rat through a Similar Hypothalamic Receptor(s): Effects of Interleukin-1 Receptor Antagonist Protein

Neuroendocrinology, 1993
Numerous reports have demonstrated that interleukin-1 beta (IL-1 beta) is a potent secretagogue for adrenocorticotropin (ACTH) and that IL-1 alpha appears to be considerably less efficacious. To clarify apparent differences in the potency of IL-1 alpha vs. -beta on ACTH secretion from a functional perspective, the IL-1 receptor antagonist protein, IRAP,
S G, Matta, K M, Linner, B M, Sharp
openaire   +2 more sources