Results 51 to 60 of about 32,812,329 (299)

New strategies to control inflammatory synovitis: interleukin 15 and beyond [PDF]

, 2003
No abstract ...
Harnett, W., Liew, F.Y., McInnes, I. B., Harnett, M., Gracie, J.A.   +4 more
core   +1 more source

The Effects of Serotonin Receptor Antagonists on Contraction and Relaxation Responses Induced by Electrical Stimulation in the Rat Small Intestine [PDF]

, 2014
Background: The main source of 5-HT in body is in enterchromafin cells of intestine, different studies mentioned different roles for endogenous 5-HT and receptors involved and it is not clearified the mechanism of action of endogenous 5-HT. Objectives:
Javid, Farideh A., Mashhadi, Farzaneh Farajian, Naylor, Robert J.   +2 more
core   +5 more sources

Effects of IL-38 on Macrophages and Myocardial Ischemic Injury

Frontiers in Immunology, 2022
Macrophages play an important role in clearing necrotic myocardial tissues, myocardial ischemia–reperfusion injury, and ventricular remodeling after myocardial infarction.
Zhiyang Li, Yan Ding, Yudong Peng, Jian Yu, Chengliang Pan, Yifan Cai, Qian Dong, Yucheng Zhong, Ruirui Zhu, Kunwu Yu, Qiutang Zeng   +10 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects.

, 2007
Interleukin-6 (IL-6) is a key inflammatory cytokine, signalling to most tissues by binding to a soluble IL-6 receptor (sIL-6r), making a complex with gp130.
A Murray, Henley, W, Bandinelli, S, S Rafiq, Rafiq, S, Weedon, MN, Guralnik, JM, Hurst, A, A-M Corsi, Ferrucci, L, K Stevens, S Bandinelli, M N Weedon, Corsi, A-M, L Ferrucci, Murray, A, D Melzer, W Henley, T M Frayling, J M Guralnik, A Hurst, Stevens, K, Melzer, D, Frayling, TM   +23 more
core   +1 more source

Mature tau pathology is not improved by interfering with interleukin-1 receptor signaling in two mouse models of tauopathy.

PLoS ONE
Prior work suggests that the cytokine interleukin-1β (IL-1β) may be a key regulator of tau pathology in the presence of amyloidosis. Here, we tested the possible benefits of interleukin-1 receptor antagonist (IL-1RA) gene therapy in two mouse models of ...
Dylan J Finneran, Brianna M Jackman, Taylor Desjarlais, Alayna Henry, Ahlam S Soliman, Patricia C Muskus, Rama Shankar, Bin Chen, Kevin R Nash, Dave Morgan, Marcia N Gordon   +10 more
doaj   +1 more source

Effect of add-on hydroxychloroquine therapy on serum proinflammatory cytokine levels in patients with systemic lupus erythematosus

Scientific Reports, 2022
We investigated the effect of hydroxychloroquine (HCQ) as an add-on treatment to immunosuppressants on the expression of proinflammatory cytokines in patients with systemic lupus erythematosus.
Risa Wakiya, Kiyo Ueeda, Shusaku Nakashima, Hiromi Shimada, Tomohiro Kameda, Mai Mahmoud Fahmy Mansour, Mikiya Kato, Taichi Miyagi, Koichi Sugihara, Mao Mizusaki, Rina Mino, Norimitsu Kadowaki, Hiroaki Dobashi   +12 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Cytokine-induced Src homology 2 protein (CIS) promotes T cell receptor-mediated proliferation and prolongs survival of activated T cells [PDF]

, 2000
Copyright @ 2000 The Rockefeller University Press. This article is shared under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ and http://creativecommons ...
Sjögren, HO, Paulsson, KM, Anette Sundstedt, Xu, X., Chen, S, Xiufeng Xu, Chen, Shangwu, Sundstedt, Anette, Karlsson, Stefan, Hans-Olov Sjögren, Karlsson, S, Li, Suling, Paulsson, Kajsa, Wang, P, Kajsa M. Paulsson, Sjögren, Hans Olov, Suling Li, Sundstedt, A, Stefan Karlsson, Xu, X, Anderson, P, Ping Wang, Wang, Ping, Shangwu Chen, Per Anderson, andersson, Per, andersson, Per,, Karlsson, Stefan,, Chen, Shangwu,, Li, Suling,, Paulsson, Kajsa,, Xu, X.,, Sjögren, Hans Olov,, Wang, Ping,, Sundstedt, Anette,, Lund University.   +35 more
core   +1 more source

Salivary cytokine levels in early gingival inflammation

Journal of Oral Microbiology, 2017
Salivary protein levels have been studied in periodontitis. However, there is lack of information on salivary cytokine levels in early gingival inflammation.
Daniel Belstrøm, Christian Damgaard, Eija Könönen, Mervi Gürsoy, Palle Holmstrup, Ulvi Kahraman Gürsoy   +5 more
doaj   +1 more source