Results 51 to 60 of about 149,441 (296)

Anti-inflammatory and atheroprotective properties of glucagon

Diabetes & Vascular Disease Research, 2020
Although glucagon has been shown to exert pleiotropic actions in various types of cells and organs through the interaction with its receptor, its pathophysiological role in atherosclerotic cardiovascular disease remains unclear. Here, we examined whether
Naoya Osaka, Hideki Kushima, Yusaku Mori, Tomomi Saito, Munenori Hiromura, Michishige Terasaki, Hironori Yashima, Makoto Ohara, Tomoyasu Fukui, Takanori Matsui, Tsutomu Hirano, Sho-ichi Yamagishi   +11 more
doaj   +1 more source

Treatment with a New Peroxisome Proliferator-Activated Receptor Gamma Agonist, Pyridinecarboxylic Acid Derivative, Increases Angiogenesis and Reduces Inflammatory Mediators in the Heart of Trypanosoma cruzi-Infected Mice [PDF]

, 2017
Trypanosoma cruzi infection induces an intense inflammatory response in diverse host tissues. The immune response and the microvascular abnormalities associated with infection are crucial aspects in the generation of heart damage in Chagas disease.
Carta, Davide, Cevey, Ágata Carolina, Dmytrenko, Ganna, Ferlin, Maria Grazia, Goren, Nora Beatriz, Mirkin, Gerardo Ariel Isidoro, Modenutti, Carlos Pablo, Penas, Federico Nicolás, Rada, Maria Jimena, Sales, María Elena   +9 more
core   +2 more sources

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Systemic inflammation and protease profile of Afro-Caribbean patients with sepsis

SAGE Open Medicine, 2021
Objectives: Sepsis is one of the leading causes of morbidity and mortality within the healthcare system and remains a diagnostic and therapeutic challenge.
Panid Borhanjoo, Navneet Singh, Sridesh Nath, MD Sadakat Chowdhury, Carl Swanson, Ryan Kaiser, Patrick Geraghty, Robert F Foronjy, Lillian Chow   +8 more
doaj   +1 more source

Effects of IL-38 on Macrophages and Myocardial Ischemic Injury

Frontiers in Immunology, 2022
Macrophages play an important role in clearing necrotic myocardial tissues, myocardial ischemia–reperfusion injury, and ventricular remodeling after myocardial infarction.
Zhiyang Li, Yan Ding, Yudong Peng, Jian Yu, Chengliang Pan, Yifan Cai, Qian Dong, Yucheng Zhong, Ruirui Zhu, Kunwu Yu, Qiutang Zeng   +10 more
doaj   +1 more source

Distribution of interleukin 1 receptor antagonist protein (IRAP), interleukin 1 receptor, and interleukin 1α in normal and psoriatic skin. Decreased expression of IRAP in psoriatic lesional epidermis

British Journal of Dermatology, 1992
The distribution of interleukin 1 alpha (IL-1 alpha), type 1 interleukin 1 receptor (IL-1R), and the interleukin 1 receptor antagonist protein (IRAP), was investigated in biopsies of normal skin, and in uninvolved and lesional skin of patients with psoriasis, using specific monoclonal antibodies.
Deleuran, Mette; id_orcid 0000-0003-0593-9925, Deleuran, B; id_orcid 0000-0002-7079-1587, Eedy, D J, Feldmann, M, Breathnach, S M, Brennan, F M   +5 more
openaire   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Effect of add-on hydroxychloroquine therapy on serum proinflammatory cytokine levels in patients with systemic lupus erythematosus

Scientific Reports, 2022
We investigated the effect of hydroxychloroquine (HCQ) as an add-on treatment to immunosuppressants on the expression of proinflammatory cytokines in patients with systemic lupus erythematosus.
Risa Wakiya, Kiyo Ueeda, Shusaku Nakashima, Hiromi Shimada, Tomohiro Kameda, Mai Mahmoud Fahmy Mansour, Mikiya Kato, Taichi Miyagi, Koichi Sugihara, Mao Mizusaki, Rina Mino, Norimitsu Kadowaki, Hiroaki Dobashi   +12 more
doaj   +1 more source

Neonatal-onset multisystem inflammatory disease responsive to interleukin-1 beta inhibition [PDF]

, 2006
BACKGROUND:Neonatal-onset multisystem inflammatory disease is characterized by fever, urticarial rash, aseptic meningitis, deforming arthropathy, hearing loss, and mental retardation.
Adams, BS, Aksentijevich, I, Beitz, LO, Brewer, C, Butman, JA, Canna, SW, Cole, JL, Dailey, NJ, Fuhlbrigge, RC, Gardner, G, Gelabert, A, Goldbach-Mansky, R, Hannan, WP, Haverkamp, MH, Hawkins, PN, Hill, S, Hoffmann, SC, Holland, SM, Horn, W, Jarvis, JN, Jones, J, Karp, BI, Kastner, DL, Kim, HJ, Moore, TL, O'Neil, K, Paul, SM, Penzak, SR, Pham, TH, Pucino, F, Rubin, BI, Shaham, B, Snyder, C, Stein, L, Turner, ML, Vehe, RK, Warren, RW, Wesley, RA, Wiggs, E, Zalewski, C   +39 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source