Results 1 to 10 of about 685,052 (299)

Cytochalasin B-Induced Membrane Vesicles from Human Mesenchymal Stem Cells Overexpressing IL2 Are Able to Stimulate CD8⁺ T-Killers to Kill Human Triple Negative Breast Cancer Cells

Biology, 2021
Interleukin 2 (IL2) was one of the first cytokines used for cancer treatment due to its ability to stimulate anti-cancer immunity. However, recombinant IL2-based therapy is associated with high systemic toxicity and activation of regulatory T-cells ...
Daria S. Chulpanova, Zarema E. Gilazieva, Sevindzh K. Kletukhina, Aleksandr M. Aimaletdinov, Ekaterina E. Garanina, Victoria James, Albert A. Rizvanov, Valeriya V. Solovyeva   +7 more
doaj   +1 more source

Harnessing Treg Homeostasis to Optimize Posttransplant Immunity: Current Concepts and Future Perspectives

Frontiers in Immunology, 2021
CD4+CD25+Foxp3+ regulatory T cells (Tregs) are functionally distinct subsets of mature T cells with broad suppressive activity and have been shown to play an important role in the establishment of immune tolerance after allogeneic hematopoietic stem cell
Shuntaro Ikegawa, Shuntaro Ikegawa, Ken-ichi Matsuoka   +2 more
doaj   +1 more source

An oncolytic adenovirus coding for a variant interleukin 2 cytokine improves response to chemotherapy through enhancement of effector lymphocyte cytotoxicity, fibroblast compartment modulation and mitotic slippage

Frontiers in Immunology, 2023
Pancreatic ductal adenocarcinoma (PDAC) is a highly treatment-resistant cancer. Currently, the only curative treatment for PDAC is surgery, but most patients are diagnosed with metastatic disease and thus outside the scope of surgery.
Santeri Pakola, Dafne C. A. Quixabeira, Dafne C. A. Quixabeira, Tatiana V. Kudling, James H. A. Clubb, James H. A. Clubb, Susanna Grönberg-Vähä-Koskela, Susanna Grönberg-Vähä-Koskela, Saru Basnet, Elise Jirovec, Elise Jirovec, Victor Arias, Lyna Haybout, Lyna Haybout, Camilla Heiniö, Joao M. Santos, Joao M. Santos, Victor Cervera-Carrascon, Victor Cervera-Carrascon, Riikka Havunen, Riikka Havunen, Marjukka Anttila, Akseli Hemminki, Akseli Hemminki, Akseli Hemminki   +24 more
doaj   +1 more source

Effectiveness of gel formulation of capa leaf (Blumea balsamifera L.) on wound healing in white rats [PDF]

Veterinary World, 2022
Background and Aim: The capa plant (Blumea balsamifera L.) has been widely used as a traditional herbal medicine in many parts of the world, including South Aceh, Indonesia.
Masyudi Masyudi, Muhammad Hanafiah, Said Usman, Marlina Marlina   +3 more
doaj   +1 more source

Dynamics of Mycobacterium tuberculosis-Specific and Nonspecific Immune Responses in Women with Tuberculosis Infection during Pregnancy

Microbiology Spectrum, 2022
The immune control of tuberculosis (TB) infection could be influenced by pregnancy. To elucidate this, we longitudinally characterized Mycobacterium tuberculosis (Mtb)-specific and nonspecific immune responses in women during pregnancy and postpartum ...
Fregenet Tesfaye, Erik Sturegård, John Walles, Bayissa Bekele, Kidist Bobosha, Per Björkman, Marianne Jansson   +6 more
doaj   +1 more source

Redistribution of DNA loop domains in human lymphocytes under blast transformation with interleukin 2 [PDF]

The Ukrainian Biochemical Journal, 2016
At higher order levels chromatin fibers in interphase nuclei are organized into loop domains. Gene regulatory elements (promoters and enhancers) are often located near the sites of loop attachments.
K. S. Afanasieva, M. I. Chopei, A. V. Lozovik, S. R. Rushkovsky, A. V. Sivolob   +4 more
doaj   +1 more source

The ADP-Ribosylation Factor 4d Restricts Regulatory T-Cell Induction via Control of IL-2 Availability

Cells, 2022
Interleukin-2 is central to the induction and maintenance of both natural (nTreg) and induced Foxp3-expressing regulatory T cells (iTreg). Thus, signals that modulate IL-2 availability may, in turn, also influence Treg homeostasis.
Bernd Geers, Julia Hagenstein, Jessica Endig, Hanna Ulrich, Laura Fleig, Paulina Sprezyna, Julita Mikulec, Lukas Heukamp, Gisa Tiegs, Linda Diehl   +9 more
doaj   +1 more source

IL-2 and Mycobacterial Lipoarabinomannan as Targets of Immune Responses in Multiple Sclerosis Patients

Microorganisms, 2020
Interleukin 2 (IL-2) is considered a key player in exacerbating multiple sclerosis (MS). Therapies targeting its receptor have been developed; however, a resolution of the disease and side effects are still an issue of concern.
Marco Bo, Magdalena Niegowska, Jessica Frau, GianPietro Sechi, Giannina Arru, Eleonora Cocco, Leonardo A. Sechi   +6 more
doaj   +1 more source

The Combined Effect of Weaning Stress and Immune Activation during Pig Gestation on Serum Cytokine and Analyte Concentrations

Animals, 2021
Weaning stress can elicit changes in the metabolic, hormone and immune systems of pigs and interact with prolonged disruptions stemming from maternal immune activation (MIA) during gestation.
Haley E. Rymut, Laurie A. Rund, Courtni R. Bolt, Maria B. Villamil, Bruce R. Southey, Rodney W. Johnson, Sandra L. Rodriguez-Zas   +6 more
doaj   +1 more source

Analysis of molecular genetic diversity of endangered Punjab urial (Ovis vignei punjabiensis) based on interleukin 2 gene sequences [PDF]

Bulgarian Journal of Veterinary Medicine, 2018
Punjab urial (Ovis vignei punjabiensis) is endemic to wild northern Punjab, Pakistan and also an endangered species according to red list categories of International Union of Conservation of Nature and Natural Resources.
T. Hussain, M. M. Musthafa, M.E.Babar, W.A.Khan, Z.Ullah, M.Aqeel, A. Yaqub , F.M.M.Marikar   +7 more
doaj   +1 more source