Results 1 to 10 of about 23,313,489 (418)

Abscopal responses in patients with metastatic melanoma involving skin and subcutaneous tissues treated with intralesional IL2 plus BCG

Frontiers in Oncology, 2023
Cutaneous melanoma is relatively common with increasing incidence and significant mortality. While the mainstay of therapy is surgical, patients with stage III and IV disease fare poorer than those with early-stage disease and often benefit from adjuvant
Dejan Vidovic, Lucy Kathryn Helyer, Sylvia Pasternak, Carman Anthony Giacomantonio   +3 more
doaj   +1 more source

An optimized cultivation method for future in vivo application of γδ T cells

Frontiers in Immunology, 2023
γδ T cells, with their properties of both the innate and acquired immune systems, are suitable candidates for cellular immunotherapy in cancer. Because of their non-major histocompatibility complex (MHC) binding T cell receptor, allogenic transfer is ...
Anna Bold, Heike Gross, Elisabeth Holzmann, Stefan Knop, Timm Hoeres, Timm Hoeres, Martin Wilhelm   +6 more
doaj   +1 more source

Phase II Trial of Maintenance Treatment With IL2 and Zoledronate in Multiple Myeloma After Bone Marrow Transplantation: Biological and Clinical Results

Frontiers in Immunology, 2021
BackgroundMaintenance treatment after autologous bone marrow transplantation in multiple myeloma improves the outcome of patients. We designed a phase II clinical trial to evaluate the treatment with IL2 and zoledronate after autologous bone marrow ...
Rita Fazzi, Iacopo Petrini, Nicola Giuliani, Riccardo Morganti, Giovanni Carulli, Benedetta Dalla Palma, Laura Notarfranchi, Sara Galimberti, Gabriele Buda   +8 more
doaj   +1 more source

Dynamics of Mycobacterium tuberculosis-Specific and Nonspecific Immune Responses in Women with Tuberculosis Infection during Pregnancy

Microbiology Spectrum, 2022
The immune control of tuberculosis (TB) infection could be influenced by pregnancy. To elucidate this, we longitudinally characterized Mycobacterium tuberculosis (Mtb)-specific and nonspecific immune responses in women during pregnancy and postpartum ...
Fregenet Tesfaye, Erik Sturegård, John Walles, Bayissa Bekele, Kidist Bobosha, Per Björkman, Marianne Jansson   +6 more
doaj   +1 more source

Effectiveness of gel formulation of capa leaf (Blumea balsamifera L.) on wound healing in white rats [PDF]

Veterinary World, 2022
Background and Aim: The capa plant (Blumea balsamifera L.) has been widely used as a traditional herbal medicine in many parts of the world, including South Aceh, Indonesia.
Masyudi Masyudi, Muhammad Hanafiah, Said Usman, Marlina Marlina   +3 more
doaj   +1 more source

Harnessing Treg Homeostasis to Optimize Posttransplant Immunity: Current Concepts and Future Perspectives

Frontiers in Immunology, 2021
CD4+CD25+Foxp3+ regulatory T cells (Tregs) are functionally distinct subsets of mature T cells with broad suppressive activity and have been shown to play an important role in the establishment of immune tolerance after allogeneic hematopoietic stem cell
Shuntaro Ikegawa, Shuntaro Ikegawa, Ken-ichi Matsuoka   +2 more
doaj   +1 more source

Cytochalasin B-Induced Membrane Vesicles from Human Mesenchymal Stem Cells Overexpressing IL2 Are Able to Stimulate CD8⁺ T-Killers to Kill Human Triple Negative Breast Cancer Cells

Biology, 2021
Interleukin 2 (IL2) was one of the first cytokines used for cancer treatment due to its ability to stimulate anti-cancer immunity. However, recombinant IL2-based therapy is associated with high systemic toxicity and activation of regulatory T-cells ...
Daria S. Chulpanova, Zarema E. Gilazieva, Sevindzh K. Kletukhina, Aleksandr M. Aimaletdinov, Ekaterina E. Garanina, Victoria James, Albert A. Rizvanov, Valeriya V. Solovyeva   +7 more
doaj   +1 more source

An oncolytic adenovirus coding for a variant interleukin 2 cytokine improves response to chemotherapy through enhancement of effector lymphocyte cytotoxicity, fibroblast compartment modulation and mitotic slippage

Frontiers in Immunology, 2023
Pancreatic ductal adenocarcinoma (PDAC) is a highly treatment-resistant cancer. Currently, the only curative treatment for PDAC is surgery, but most patients are diagnosed with metastatic disease and thus outside the scope of surgery.
Santeri Pakola, Dafne C. A. Quixabeira, Dafne C. A. Quixabeira, Tatiana V. Kudling, James H. A. Clubb, James H. A. Clubb, Susanna Grönberg-Vähä-Koskela, Susanna Grönberg-Vähä-Koskela, Saru Basnet, Elise Jirovec, Elise Jirovec, Victor Arias, Lyna Haybout, Lyna Haybout, Camilla Heiniö, Joao M. Santos, Joao M. Santos, Victor Cervera-Carrascon, Victor Cervera-Carrascon, Riikka Havunen, Riikka Havunen, Marjukka Anttila, Akseli Hemminki, Akseli Hemminki, Akseli Hemminki   +24 more
doaj   +1 more source

Interleukin‐1α, interleukin‐2, and soluble interleukin‐2 receptors in polymyositis [PDF]

Arthritis & Rheumatism, 1990
AbstractCell‐mediated immunity has been implicated in the pathogenesis of polymyositis (PM). We conducted a prospective study in which serum levels of soluble interleukin‐2 receptors (IL‐2R), IL‐1α, and IL‐2 were correlated with creatine kinase (CK) levels and clinical disease activity.
Bruce A. Baethge, Robert E. Wolf
openaire   +3 more sources

Effects of oral administration of 5 immunosuppressive agents on activated T‐cell cytokine expression in healthy dogs

Journal of Veterinary Internal Medicine, 2020
Background Dogs are often adminstered >1 immunosuppressive medication when treating immune‐mediated diseases, and determining whether these different medications affect IL‐2 expression would be useful when performing pharmacodynamic monitoring during ...
Todd M. Archer, Charlee Mulligan, Lakshmi Narayanan, Caitlin Riggs, Claire Fellman, John M. Thomason, Robert W. Wills, Dawn M. Boothe, Crisanta Cruz‐Espindola, Roy Harmon, Andrew J. Mackin   +10 more
doaj   +1 more source