Results 111 to 120 of about 23,313,489 (418)

Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism [PDF]

, 2011
SummaryIn cytotoxic T cells (CTL), Akt, also known as protein kinase B, is activated by the T cell antigen receptor (TCR) and the cytokine interleukin 2 (IL-2). Akt can control cell metabolism in many cell types but whether this role is important for CTL
Ahmed, Andrew N. Macintyre, Araki, Bachmann, Bain, Bayascas, Bayascas, Carlson, Carmen Feijoo, Caryll M. Waugh, Castellino, Cham, Cornish, Cruz-Guilloty, D'Souza, David Finlay, Doreen A. Cantrell, Fabre, Finlay, Fox, Garçon, Gavin Preston, Green, Hand, Hendriks, Jacobs, Janas, Jarmin, Juntilla, Kaech, Kalia, Kelly, Kerdiles, Klaus Okkenhaug, Kurts, Lin, Linda V. Sinclair, Liu, Maciver, Malek, Manjunath, Mao, Obar, Ouyang, Pearce, Peter Tamas, Pipkin, Pircher, Prlic, Rao, Rathmell, Saeed, Saibil, Sinclair, Soond, Tamás, Waugh, Williams, Williams   +58 more
core   +3 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Structure-function relationships for the interleukin 2 receptor system

Memorias do Instituto Oswaldo Cruz, 1987
Receptors for interleukin 2 (IL-2) esit in at least three forms which differ in their subunit compositio, their affinity for ligand and their ability to mediate a cellular reponse.
Richard J. Robb
doaj   +1 more source

Immunity to Plasmodium knowlesi H strain malaria in olive baboons [PDF]

Int. J. Integ. Biol. Volume 10, Issue No. 3: 147 -- 152 (2010), 2012
Malaria disease is a major global health and economic development threat. It results in approximately 2.7 million deaths annually. There is currently no vaccine that has been licensed for use against malaria. Studies in animal models, especially non-human primates can lead to the revelation of possible immunological mechanisms that can lead to ...
arxiv  

Population balances in case of crossing characteristic curves: Application to T-cells immune response [PDF]

, 2016
The progression of a cell population where each individual is characterized by the value of an internal variable varying with time (e.g. size, weight, and protein concentration) is typically modeled by a Population Balance Equation, a first order linear hyperbolic partial differential equation.
arxiv   +1 more source

Unsaturated fatty acids suppress interleukin-2 production and transferrin receptor expression by concanavalin A-stimulated rat Iymphocytes [PDF]

, 1992
The proliferation of T-lymphocytes is dependent upon their ability to synthesize and secrete the cytokine, interleukin-2, and to express cell surface receptors for interleukin-2 and transferrin.
Calder, Philip C., Newsholme, Eric A.
core   +4 more sources

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

The IL-2 – IL-2 receptor pathway: Key to understanding multiple sclerosis

Journal of Translational Autoimmunity, 2021
The development, progression, diagnosis and treatment of autoimmune diseases, such as multiple sclerosis (MS), are convoluted processes which remain incompletely understood. Multiple studies demonstrated that the interleukin (IL)-2 – IL-2 receptor (IL-2R)
Daphne Peerlings, Max Mimpen, Jan Damoiseaux   +2 more
doaj  

Correlations between Serum Interleukins-2,-4 Levels and Some Biochemical Parameters in Iraqi Patients with Osteoporosis

مجلة كلية الطب, 2017
Background: Osteoporosis is a frequent disease that is manifested by reduced in mineral density and raised in fracture risk. Recent studies have indicated that osteoporosis is caused by composite connections among local and systemic regulators of bone ...
Hind Sh. Ahmed
doaj   +1 more source

Cytokine expression in malaria-infected non-human primate placentas [PDF]

M. Barasa, Z.W. Ng'ang'a et al. Cytokine expression in malaria-infected non-human primate placentas. Open Veterinary Journal, (2012), Vol. 2: 58-64, 2012
Malaria parasites are known to mediate the induction of inflammatory immune responses at the maternal-foetal interface during placental malaria (PM) leading to adverse consequences like pre-term deliveries and abortions. Immunological events that take place within the malaria-infected placental micro-environment leading to retarded foetal growth and ...
arxiv