Results 131 to 140 of about 23,313,489 (418)
Interleukin- 2 production during murine infection by Leishmania mexicana amazonensis
Memorias do Instituto Oswaldo Cruz, 1986 Highly susceptible BALB/c mice, resistant C57B1/6 and their F1 progeny (BDF1) were infected subcutaneously in the foot pad with Leishmania mexicana amazonenesis. At various times after infection, spleen or draining popliteal lymph node cells were assayed
Manoel Barral-Netto +2 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Objectives Ofatumumab, a fully human anti‐CD20 monoclonal antibody, is effective in reducing relapses and disability progression in patients with multiple sclerosis. This study aimed to examine immune profile changes associated with ofatumumab in a prospective cohort of Chinese patients with relapsing–remitting multiple ...
Shu Yang +9 more
wiley +1 more source
Frontiers in ImmunologyImmunotherapy of tumors plays a pivotal role in the current treatment of cancer. While interleukin 2 (IL-2) demonstrated its efficacy as an immunotherapeutic drug in the early days, its short blood circulation time poses challenges in maintaining ...
Di Wang +7 more
doaj +1 more source
Interleukin 2 modulates thymic-derived regulatory T cell epigenetic landscape
Nature Communications, 2018 Regulatory T (Treg) cells are developed in the thymus, and are essential for suppressing detrimental autoimmunity. Here the authors show, using mice with dampened interleukin 2 (IL-2) signaling, that IL-2 helps position the pioneer factor SATB1 to ...
Laurent Chorro +7 more
doaj +1 more source
Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor.
Science, 1993 The interleukin-2 receptor gamma chain (IL-2R gamma) is a necessary component of functional IL-2 receptors. IL-2R gamma mutations result in X-linked severe combined immunodeficiency (XSCID) in humans, a disease characterized by the presence of few or no ...
M. Noguchi +6 more
semanticscholar +1 more source
Osteoprotegerin mediates tumor-promoting effects of Interleukin-1beta in breast cancer cells [PDF]
, 2017 __Background:__ It is widely recognized that inflammation promotes breast cancer invasion and metastasis. Given the complex nature of the breast tumor inflammatory microenvironment, much remains to be understood of the molecular mechanisms that govern ...
Chung, S.T.M. (Stephanie Tsang Mui) +4 more
core +2 more sources
Arthritis Care &Research, EarlyView.Objective We aimed to assess differences in baseline characteristics, efficacy, and safety of advanced therapies between male and female patients with axial spondyloarthritis (axSpA) in randomized controlled trials (RCTs). Methods We conducted a systematic literature search for RCTs assessing the efficacy of advanced therapies in patients with axSpA ...
Angel Gao +5 more
wiley +1 more source
Acta Biomedica ScientificaBackground. Immunological studies are impossible without long-term storage of cryopreserved biomaterial. There are no standard procedures for working with cryopreserved mononuclear leukocytes.The aim of the study. To optimize the protocol for culturing T
E. V. Saidakova +3 more
doaj +1 more source
Identification of Interaction Clusters Using a Semi-supervised Hierarchical Clustering Method [PDF]
arXiv, 2019 Motivation: Identifying interaction clusters of large gene regulatory networks (GRNs) is critical for its further investigation, while this task is very challenging, attributed to data noise in experiment data, large scale of GRNs, and inconsistency between gene expression profiles and function modules, etc.
arxiv