High‐Throughput Microfluidic‐Mediated Assembly of Layer‐By‐Layer Nanoparticles
The layer‐by‐layer (LbL) assembly of polymer films on nanoparticle (NP) surfaces is a promising technique for targeted drug delivery. Despite its success in preclinical mouse models, a current good manufacturing practices (cGMP) compliant, clinical‐scale production method has been lacking.
Ivan S. Pires+4 more
wiley +1 more source
Plasmodium knowlesi H strain pregnancy malaria immune responses in olive baboons (Papio anubis) [PDF]
Approximately 24 million pregnant women in Sub-Saharan Africa are at risk of suffering from pregnancy malaria complications. Mechanisms responsible for increased susceptibility to malaria in pregnant women are not fully understood. Baboons are susceptible to Plasmodium knowlesi and their reproductive physiology and host pathogen interactions are ...
arxiv
Macrophage-independent activation of helper T cells. I. Production of Interleukin 2. [PDF]
Jeremy Farrar+4 more
openalex +1 more source
This paper presents a microphysiological system containing an array of individually addressable living corneal tissues constructed using primary human cells. The bioengineered eye model can simulate acute exposure of the human cornea to different types of environmental toxicants and provides a novel platform for visualization and quantitative ...
Se‐jeong Kim+12 more
wiley +1 more source
MiStImm: a simulation tool to compare classical nonsef-centered immune models with a novel self-centered model [PDF]
Our main purpose is to compare classical nonself-centered, two-signal theoretical models of the adaptive immune system with a novel, self-centered, one-signal model developed by our research group. Our model hypothesizes that the immune system of a fetus is capable learning the limited set of self antigens but unable to prepare itself for the unlimited
arxiv
Biological and biochemical characterization of bovine interleukin 2. Studies with cloned bovine T cells. [PDF]
Wendy C. Brown, Dennis J. Grab
openalex +1 more source
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray+2 more
wiley +1 more source
Molecular and functional characterization of chicken interleukin 1 receptor 2 (chIL-1R2)
: Interleukin-1 receptor type 2 (IL1R2) is a decoy receptor for exogenous IL-1. However, its functional role in chicken immunity is poorly understood. Herein, chicken IL-1R2 (chIL-1R2) was identified and functionally characterized in vivo and in vitro ...
Anh Duc Truong+7 more
doaj
Canonical Forms of $2 \times 2 \times 2$ and $2 \times 2 \times 2 \times 2$ Symmetric Tensors over Prime Fields [PDF]
We consider symmetric tensors of format $2 \times 2 \times 2$ and $2 \times 2 \times 2 \times 2$ over prime fields. Using computer algebra we compute the canonical forms of these tensors. For $2 \times 2 \times 2$ symmetric tensors, we consider the prime fields $\mathbb{F}_p$ for $p = 2, 3, 5, 7, 11, 13, 17$.
arxiv
The biochemical and biological characterization of lymphocyte regulatory molecules. VI. Generation of a B cell hybridoma whose antibody product inhibits interleukin 2 activity. [PDF]
Steven Gillis, Christopher S. Henney
openalex +1 more source