Results 161 to 170 of about 685,052 (299)

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

Advanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian, Jing Zhu, Jianhong Wu, Yan Zhang, Jianghua Chen, Huan Wang, Hengyan Liu, Ke Xu, Jiaxin Huang, Xiaoting Zhu, Yuanli Wei, Shilin Li, Tingting Wang, Xuan Huang, Qinghua Zou, Jie Zhang, Jiang Su, Xinming Du, Yaping Lu, Tianci Zhou, Yingtong Zhou, Minglong Tang, Bin Li, Xue Zhou, Qihao Wei, Qiulong Yan, Fanxin Zeng   +26 more
wiley   +1 more source

Selectivity of bovine interleukin-2 mutein stimulation on bovine peripheral blood mononuclear cells. [PDF]

J Vet Med Sci
Mitoma S, Uto T, Fukaya T, Tominaga M, Sekiguchi S, Sato K, Norimine J.   +6 more
europepmc   +1 more source

Serum Soluble Interleukin-2 Receptor Is a Biomarker for <i>Pneumocystis jirovecii</i> Pneumonia among Patients with Rheumatoid Arthritis under Methotrexate Therapy

, 2019
Noriho Sakamoto, Shintaro Hara, Hiroshi Ishimoto, Shota Nakashima, Hirokazu Yura, Takuto Miyamura, Daisuke Okuno, Atsuko Hara, Tomoyuki Kakugawa, Hiroyuki Yamaguchi, Yasushi Obase, Hisako Kushima, Hiroshi Ishii, Shingo Noguchi, Takashi Kido, Tsutomu Kobayashi, Yoshifumi Soejima, Sumako Yoshioka, Yuji Ishimatsu, Kazuhiro Yatera, Jun‐ichi Kadota, Hiroshi Mukae   +21 more
openalex   +2 more sources

Biocatalytic Nanoregulators Restore Joint Redox‐Immune Homeostasis in Rheumatoid Arthritis

Advanced Science, EarlyView.
Mesenchymal stem cell‐derived extracellular vesicles (EVs) coat ruthenium‐loaded metal‐organic frameworks (Ru@ZrMOF), creating a targeted therapeutic (Ru@ZrMOF/EVs). This platform scavenges ROS, generates oxygen, and polarizes macrophages from M1 to M2, alleviating inflammation, inhibiting pannus, promoting cartilage repair, and downregulating HIF‐1α ...
Xingheng Wang, Jianbo Huang, Shuwei Zhang, Sujiao Cao, Fangxue Du, Liqiang Zhou, Li Qiu, Yuanjiao Tang   +7 more
wiley   +1 more source

Retrospective analysis of sorafenib combined with interferon α-1b, interleukin-2, and thalidomide as maintenance therapy in FLT3-ITD-positive acute myeloid leukemia. [PDF]

Front Oncol
Cheng C, Mi R, Li D, Chen L, Wei X.
europepmc   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Secretion of human interleukin 2 by recombinant Mycobacterium bovis BCG [PDF]

, 1995
Dequan Kong, Dennis Kunimoto
openalex   +1 more source

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

Advanced Science, EarlyView.
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong, Di Wang, Haoze Song, Ting Sun, Yanhong Zhao, Wenjing Gu, Lexuan Lin, Yitong Zhao, Yipeng Liang, Xu Jin, Rongfeng Fu, Mankai Ju, Jie Gao, Jinfa Ma, Chengjie Gao, Anqi Zhang, Zhijian Xiao, Erlie Jiang, Renchi Yang, Shihui Ma, Lei Zhang, Lihong Shi   +21 more
wiley   +1 more source

Targeted regulatory T cell activation by site-specific PEGylated interleukin-2 mitigates autoimmune inflammation. [PDF]

J Transl Autoimmun
Ikeda M, Yamaguchi S, Takaoka S, Sakaguchi Y, Yasui S.   +4 more
europepmc   +1 more source

Interleukin-2 therapy enhances salicylate oxidation by blood granulocytes [PDF]

, 1991
AL Jr Sagone, RM Husney, Triozzi Pl, J Rinehart   +3 more
openalex   +1 more source