Results 11 to 20 of about 1,083,667 (362)

An oncolytic adenovirus coding for a variant interleukin 2 cytokine improves response to chemotherapy through enhancement of effector lymphocyte cytotoxicity, fibroblast compartment modulation and mitotic slippage

open access: yesFrontiers in Immunology, 2023
Pancreatic ductal adenocarcinoma (PDAC) is a highly treatment-resistant cancer. Currently, the only curative treatment for PDAC is surgery, but most patients are diagnosed with metastatic disease and thus outside the scope of surgery.
Santeri Pakola   +24 more
doaj   +1 more source

Dynamics of Mycobacterium tuberculosis-Specific and Nonspecific Immune Responses in Women with Tuberculosis Infection during Pregnancy

open access: yesMicrobiology Spectrum, 2022
The immune control of tuberculosis (TB) infection could be influenced by pregnancy. To elucidate this, we longitudinally characterized Mycobacterium tuberculosis (Mtb)-specific and nonspecific immune responses in women during pregnancy and postpartum ...
Fregenet Tesfaye   +6 more
doaj   +1 more source

Effectiveness of gel formulation of capa leaf (Blumea balsamifera L.) on wound healing in white rats [PDF]

open access: yesVeterinary World, 2022
Background and Aim: The capa plant (Blumea balsamifera L.) has been widely used as a traditional herbal medicine in many parts of the world, including South Aceh, Indonesia.
Masyudi Masyudi   +3 more
doaj   +1 more source

Redistribution of DNA loop domains in human lymphocytes under blast transformation with interleukin 2 [PDF]

open access: yesThe Ukrainian Biochemical Journal, 2016
At higher order levels chromatin fibers in interphase nuclei are organized into loop domains. Gene regulatory elements (promoters and enhancers) are often located near the sites of loop attachments.
K. S. Afanasieva   +4 more
doaj   +1 more source

The ADP-Ribosylation Factor 4d Restricts Regulatory T-Cell Induction via Control of IL-2 Availability

open access: yesCells, 2022
Interleukin-2 is central to the induction and maintenance of both natural (nTreg) and induced Foxp3-expressing regulatory T cells (iTreg). Thus, signals that modulate IL-2 availability may, in turn, also influence Treg homeostasis.
Bernd Geers   +9 more
doaj   +1 more source

IL-2 and Mycobacterial Lipoarabinomannan as Targets of Immune Responses in Multiple Sclerosis Patients

open access: yesMicroorganisms, 2020
Interleukin 2 (IL-2) is considered a key player in exacerbating multiple sclerosis (MS). Therapies targeting its receptor have been developed; however, a resolution of the disease and side effects are still an issue of concern.
Marco Bo   +6 more
doaj   +1 more source

The Combined Effect of Weaning Stress and Immune Activation during Pig Gestation on Serum Cytokine and Analyte Concentrations

open access: yesAnimals, 2021
Weaning stress can elicit changes in the metabolic, hormone and immune systems of pigs and interact with prolonged disruptions stemming from maternal immune activation (MIA) during gestation.
Haley E. Rymut   +6 more
doaj   +1 more source

Analysis of molecular genetic diversity of endangered Punjab urial (Ovis vignei punjabiensis) based on interleukin 2 gene sequences [PDF]

open access: yesBulgarian Journal of Veterinary Medicine, 2018
Punjab urial (Ovis vignei punjabiensis) is endemic to wild northern Punjab, Pakistan and also an endangered species according to red list categories of International Union of Conservation of Nature and Natural Resources.
T. Hussain   +7 more
doaj   +1 more source

Interleukin‐1α, interleukin‐2, and soluble interleukin‐2 receptors in polymyositis [PDF]

open access: yesArthritis & Rheumatism, 1990
AbstractCell‐mediated immunity has been implicated in the pathogenesis of polymyositis (PM). We conducted a prospective study in which serum levels of soluble interleukin‐2 receptors (IL‐2R), IL‐1α, and IL‐2 were correlated with creatine kinase (CK) levels and clinical disease activity.
Bruce A. Baethge, Robert E. Wolf
openaire   +3 more sources

Administration of fusion cytokines induces tumor regression and systemic antitumor immunity

open access: yesMedComm, 2021
It is difficult to improve the curative effects of cancer immunotherapy on solid tumors. Cytokines, as powerful immune regulators, show potential in activating host antitumor immunity.
Jinyu Zhang, Xuan Zhao
doaj   +1 more source

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