Results 11 to 20 of about 22,989,400 (391)
Interleukin‐1α, interleukin‐2, and soluble interleukin‐2 receptors in polymyositis [PDF]
Arthritis & Rheumatism, 1990 AbstractCell‐mediated immunity has been implicated in the pathogenesis of polymyositis (PM). We conducted a prospective study in which serum levels of soluble interleukin‐2 receptors (IL‐2R), IL‐1α, and IL‐2 were correlated with creatine kinase (CK) levels and clinical disease activity.
Bruce A. Baethge, Robert E. Wolf
openaire +3 more sources
Frontiers in Physiology, 2016 Increased pressure, associated with diving, can alter cell function through several mechanisms and has been shown to impact immune functions performed by peripheral blood mononuclear cells (PBMC) in humans.
Laura A Thompson, Tracy A. Romano
doaj +1 more source
Microorganisms, 2020 Interleukin 2 (IL-2) is considered a key player in exacerbating multiple sclerosis (MS). Therapies targeting its receptor have been developed; however, a resolution of the disease and side effects are still an issue of concern.
Marco Bo +6 more
doaj +1 more source
Signaling and Function of Interleukin-2 in T Lymphocytes.
Annual Review of Immunology, 2018 The discovery of interleukin-2 (IL-2) changed the molecular understanding of how the immune system is controlled. IL-2 is a pleiotropic cytokine, and dissecting the signaling pathways that allow IL-2 to control the differentiation and homeostasis of both
S. Ross, D. Cantrell
semanticscholar +1 more source
Mathematical Models of the impact of IL2 modulation therapies on T cell dynamics
Frontiers in Immunology, 2013 Several reports in the literature have drawn a complex picture of the effect of treatments aiming to modulate IL2 activity in vivo. They seem to promote either immunity or tolerance, probably depending on the specific context, dose and timing of their ...
Kalet eLeon +2 more
doaj +1 more source
Expression of inflammation-related genes is associated with adipose tissue location in horses [PDF]
, 2013 Background : In humans, adipose tissue (AT) originating from different depots shows varying gene expression profiles. In horses, the risk of certain metabolic disorders may also be influenced by the impact of specific AT depots.
Bruynsteen, Lien +6 more
core +2 more sources
Journal of Experimental Medicine, 1998 Peripheral tolerance may be maintained by a population of regulatory/suppressor T cells that prevent the activation of autoreactive T cells recognizing tissue-specific antigens.
A. Thornton, E. Shevach
semanticscholar +1 more source
Effects of interleukin-2 in immunostimulation and immunosuppression
Journal of Experimental Medicine, 2019 Distinctions in the nature and spatiotemporal expression of IL-2R subunits on conventional versus regulatory T cells are exploited to manipulate IL-2 immunomodulatory effects.
Jonathan G. Pol +4 more
semanticscholar +1 more source
OncoImmunology, 2019 Immunotherapy with the anti-GD2 antibody (Ab) ch14.18/CHO in combination with interleukin 2 (IL-2) has improved survival of high-risk neuroblastoma (NB) patients.
Sascha Troschke-Meurer +8 more
doaj +1 more source
Frontiers in Pediatrics, 2020 Patients with high-risk neuroblastoma treated with continuous long-term infusion of anti-GD2 antibody dinutuximab beta (DB) in combination with IL-2 show an acceptable safety profile. Here, we compared treatment tolerance with and without IL-2.
Filiz Cicek +7 more
doaj +1 more source