Results 201 to 210 of about 1,083,667 (362)

Digitonin‐Loaded Nanoscale Metal–Organic Framework for Mitochondria‐Targeted Radiotherapy‐Radiodynamic Therapy and Disulfidptosis

Advanced Materials, EarlyView.
A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen, Yingjie Fan, Tomas Germanas, Langston Tillman, Jinhong Li, Abigail L. Blenko, Ralph R. Weichselbaum, Wenbin Lin   +7 more
wiley   +1 more source

Targeted regulatory T cell activation by site-specific PEGylated interleukin-2 mitigates autoimmune inflammation. [PDF]

J Transl Autoimmun
Ikeda M, Yamaguchi S, Takaoka S, Sakaguchi Y, Yasui S.   +4 more
europepmc   +1 more source

A phase I clinical trial of recombinant interleukin 2 following high dose chemo-radiotherapy for haematological malignancy: applicability to the elimination of minimal residual disease

, 1989
David Gottlieb, MK Brenner, HE Heslop, ACM Bianchi, C Bello-Fernández, AB Mehta, AC Newland, AR Galazka, EM Scott, A. V. Hoffbrand, H. G. Prentice   +10 more
openalex   +1 more source

Selective Lipolysis by Photoactivation of Chaperone‐Mediated Autophagy Using Adipocyte Membrane‐Coated Nanoparticle in Hydrogel

Advanced Materials, EarlyView.
Adipocyte membrane‐coated nanoparticles loaded with rosiglitazone in hydrogel offer an alternative approach to conventional obesity treatments. This system selectively targets adipocytes, inducing lipolysis by activating chaperone‐mediated autophagy through mild photothermal stimulation.
Jaehyun Choi, Junho Byun, Dongyoon Kim, Qiaoyun Li, Dongun Jin, Yeong‐jin Choi, Ho Sang Jung, Jaiwoo Lee, Yu‐Kyoung Oh   +8 more
wiley   +1 more source

Universal Method for Covalent Attachment of Hydrogels to Diverse Polymeric Surfaces for Biomedical Applications

Advanced Materials, EarlyView.
A universal, reagent‐free strategy is presented for covalently attaching hydrogels to diverse polymeric substrates through reactive oxygen species. The scalable, linker‐free approach enables robust adhesion and broad material compatibility, advancing the fabrication of hybrid solid–hydrogel systems for next‐generation biomedical devices and bioprinting
Masoud Zhianmanesh, Azin Khodaei, Matthew Crago, Oliver Lotz, Sina Naficy, Fariba Dehghani, Marcela Bilek, Saber Amin Yavari, Behnam Akhavan   +8 more
wiley   +1 more source

Serum soluble interleukin-2 receptor levels in hairy cell leukaemia as a marker of tumour burden with prognostic value and as a tool for disease monitoring. [PDF]

Br J Haematol
Angotzi F, Cellini A, Danesin N, Zoletto S, Serafin A, Cavarretta CA, Bevilacqua A, Forlani L, Tonini A, Frezzato F, Bonaldi L, Pizzi M, Faggian D, Trentin L, Visentin A.   +14 more
europepmc   +1 more source

The development of anti-interleukin-2 antibodies in patients treated with recombinant human interleukin-2 (IL-2) [PDF]

, 1986
Mark Allegretta, Michael B. Atkins, Roy A. Dempsey, Edward C. Bradley, Michael Konrad, Ann Childs, Sidney Wolfe, James W. Mier   +7 more
openalex   +1 more source

Dendrimers Improve Apolipoprotein Nanoparticle mRNA Delivery to Immune Cells

Advanced Materials, EarlyView.
Apolipoprotein nanoparticle (aNP) platform technology efficiently delivers RNA to immune cells following systemic administration. Here, it is demonstrated that incorporating polyvalent ionizable cationic dendrimers in aNPs enables robust mRNA complexation and functional delivery.
Mirre M. Trines, Daniek Hoorn, Stijn R.J. Hofstraat, Robby C. Zwolsman, Tom Anbergen, Iris Versteeg, Yuri van Elsas, Jeroen Deckers, Merel M.A. Hendrikx, Teun Kleuskens, Youssef B. Darwish, Gijs W.B. Ros, Sjoerd F. Dijkstra, Bram Priem, Matt Timmers, P. Michel Fransen, Maarten J. Pouderoijen, Bas F.M. de Waal, E.W. Meijer, Thijs J. Beldman, Yohana C. Toner, Ewelina Kluza, Willem J.M. Mulder, Henk M. Janssen, Roy van der Meel   +24 more
wiley   +1 more source

Histamine dihydrochloride and low-dose interleukin-2 in an emerging landscape of relapse prevention in acute myeloid leukemia. [PDF]

Ther Adv Hematol
Nilsson MS, Martner A, Wennström L, Hansson M, Thorén FB, Hellstrand K.   +5 more
europepmc   +1 more source

Evidence for the interleukin-2 dependent expansion of leukemic cells in adult T cell leukemia

, 1987
M Maeda, Nobuyoshi Arima, Y Daitoku, M Kashihara, Hisashi Okamoto, T Uchiyama, Kenji Shirono, Masao Matsuoka, Takamitsu Hattori, Kiyoshi Takatsuki   +9 more
openalex   +1 more source