Results 201 to 210 of about 685,052 (299)

The IL-2/IL-2-Receptor Complex in the Maturation of Rat T-Cell Progenitors

Clinical and Developmental Immunology, 1998
Alberto Varas, Teresa Romo, Eva Jiménez, Luis Alonso, Angeles Vicente, Agustín G. Zapata   +5 more
doaj   +1 more source

Oncolytic adenovirus encoding variant interleukin-2 combined with chemotherapy enables PD-L1 inhibition in pancreatic cancer models. [PDF]

Cancer Immunol Immunother
Pakola SA, Ojala N, Kudling TV, Clubb JHA, Jirovec E, van der Heijden M, Arias V, Haybout L, Basnet S, Grönberg-Vähä-Koskela S, Quixabeira DCA, Santos JM, Cervera-Carrascon V, Hemminki O, Kanerva A, Mustonen H, Puolakkainen P, Seppänen H, Hemminki A.   +18 more
europepmc   +1 more source

Production of interleukin-2; in response to synthetic peptides from hepatitis C virus E1 protein in patients with chronic hepatitis C: relationship with the response to interferon treatment

, 2017
Pablo Sarobe, J.I. Jaúregui, Juan José Lasarte, Nicolás Garcı́a, M.P. Civeira, Francisco Borrás‐Cuesta, Jesús Prìeto   +6 more
openalex   +2 more sources

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Coordinating interleukin-2 encoding circRNA with immunomodulatory lipid nanoparticles to potentiate cancer immunotherapy. [PDF]

Sci Adv
Yang K, Bai B, Li X, Rou W, Huang C, Lu M, Zhang X, Dong C, Qi S, Liu Z, Yu G.   +10 more
europepmc   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol‐Driven WNT7B Suppression

Advanced Science, EarlyView.
This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li, Yanjie Guo, Jianlin Li, Yimeng Li, Leqian Lin, Hoi Kit Matthew Leung, Qingqing Zhang, Kai‐Fai Lee, Ka‐Wang Cheung, Ernest H. Y. Ng, William S. B. Yeung, Philip C. N. Chiu, Cheuk‐Lun Lee   +12 more
wiley   +1 more source

[⁶⁸Ga]Ga-interleukin-2 for imaging activated T-lymphocytes: biochemical characterization and phase I study in normal subjects. [PDF]

Eur J Nucl Med Mol Imaging
Signore A, Galli F, Varani M, Campagna G, Bentivoglio V, Accardo A, Morelli G, Lauri C.   +7 more
europepmc   +1 more source

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

Stratum Corneum Interleukin-2 in Facial Eczema at 1-Month-Old Predicts Later Atopic Dermatitis. [PDF]

Allergy
Maehara E, Kido-Nakahara M, Fujita Y, Kato K, Kido S, Yamasaki R, Nagata S, Kishimoto J, Watanabe H, Harada E, Nagashima Y, Umeno E, Tsuji G, Esaki H, Nakahara T.   +14 more
europepmc   +1 more source