Results 281 to 290 of about 23,313,489 (418)

Generation of lymphokine-activated killer cells: synergy between tumor necrosis factor and interleukin 2.

, 1988
Salem Chouaı̈b, Jacques Bertoglio, Jean‐Yves Blay, Carmen Marchiol, D Fradelizi   +4 more
openalex   +1 more source

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Advanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun   +10 more
wiley   +1 more source

[Biological activity and antitumor effect of long-acting recombinant human interleukin-2 drug]. [PDF]

Beijing Da Xue Xue Bao Yi Xue Ban
Liang X, Zhang F, Jin T, Zhu J.
europepmc   +1 more source

A phase I clinical trial of recombinant interleukin 2 following high dose chemo-radiotherapy for haematological malignancy: applicability to the elimination of minimal residual disease

, 1989
David Gottlieb, MK Brenner, HE Heslop, ACM Bianchi, C Bello-Fernández, AB Mehta, AC Newland, AR Galazka, EM Scott, A. V. Hoffbrand, H. G. Prentice   +10 more
openalex   +1 more source

An antigen receptor-driven, interleukin 2-independent pathway for proliferation of murine cytolytic T lymphocyte clones. [PDF]

, 1986
R L Moldwin, D W Lancki, Kevan C. Herold, F W Fitch   +3 more
openalex   +1 more source

Lactylation‐Driven NUPR1 Promotes Immunosuppression of Tumor‐Infiltrating Macrophages in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Cai et al. report that tumor‐derived lactate induces NUPR1 expression via H3K18 lactylation, which can promote the pro‐tumor M2 macrophage polarization through ERK and JNK signaling pathways. Treatment with NUPR1 selective inhibitor sensitizes synergizes with anti‐PD‐1 therapy in murine preclinical models.
Jialiang Cai, Peiling Zhang, Yufan Cai, Guiqi Zhu, Shiping Chen, Lina Song, Junxian Du, Biao Wang, Weixing Dai, Jian Zhou, Jia Fan, Yiyi Yu, Zhi Dai   +12 more
wiley   +1 more source

Interleukin-2 improves insulin sensitivity through hypothalamic sympathetic activation in obese mice. [PDF]

J Neuroinflammation
Moon S, Park Y, Jang S, Kim S, Song DG, Shin DC, Lee CH.   +6 more
europepmc   +1 more source

Effects of anti-proliferative cyclic AMP on interleukin 2-stimulated gene expression. [PDF]

, 1987
William L. Farrar, Stephen Evans, U R Rapp, John L. Cleveland   +3 more
openalex   +1 more source

Verteporfin‐Mediated In Situ Nanovaccine Based on Local Conventional‐Dose Hypofractionated Radiotherapy Enhances Antitumor and Immunomodulatory Effect

Advanced Science, EarlyView.
Here gelatinase‐responsive methoxypolyethyleneglycol–PVGLIG–polycaprolactone (mPEG–PVGLIG–PCL) nanoparticles’ loading verteporfin (N@VP) is developed, enhancing radiotherapy via X‐ray‐triggered singlet oxygen generation. Combined with 2 Gy (gray, a radiation dose unit) irradiation, N@VP achieves antitumor efficacy comparable to 8 Gy, and also promotes ...
Zhifan Zhang, Lin Li, Yuchen Ge, Anni Chen, Shanchao Diao, Yueling Yang, Qianyue Chen, Yingling Zhou, Jie Shao, Fanyan Meng, Lixia Yu, Manman Tian, Xiaoping Qian, Zhaoyu Lin, Chen Xie, Baorui Liu, Rutian Li   +16 more
wiley   +1 more source

Nemvaleukin alfa, a modified interleukin-2 cytokine, as monotherapy and with pembrolizumab in patients with advanced solid tumors (ARTISTRY-1). [PDF]

J Immunother Cancer
Vaishampayan UN, Muzaffar J, Winer I, Rosen SD, Hoimes CJ, Chauhan A, Spreafico A, Lewis KD, Bruno DS, Dumas O, McDermott DF, Strauss JF, Chu QS, Gilbert L, Chaudhry A, Calvo E, Dalal R, Boni V, Ernstoff MS, Velcheti V.   +19 more
europepmc   +1 more source