Results 321 to 330 of about 1,083,667 (362)
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Interleukin-2 and interleukin-15: immunotherapy for cancer
Cytokine & Growth Factor Reviews, 2002Interleukin (IL)-2 and IL-15 are two cytokine growth factors that regulate lymphocyte function and homeostasis. Early clinical interest in the use of IL-2 in the immunotherapy of renal cell carcinoma and malignant melanoma demonstrated the first efficacy for cytokine monotherapy in the treatment of neoplastic disease.
Megan A. Cooper +2 more
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Differential bioassay of interleukin 2 and interleukin 4
Journal of Immunological Methods, 1987The T cell-derived lymphokines interleukin 2 (IL-2) and interleukin 4 (IL-4, originally BSF-1) both exhibit T cell growth-promoting activity. Recent observations that T cell lines commonly used as indicator cells in IL-2 bioassays also proliferate in response to IL-4 demonstrate the lack of specificity of these bioassays for IL-2.
Robert T. Abraham +3 more
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The Journal of Immunology, 1985
Abstract The role of interleukin 2 (IL 2) on the expression of IL 2 receptors and on the synthesis of gamma-interferon (gamma-IFN) by human thymocytes was investigated. Human thymocytes isolated from specimens obtained during cardiac surgery of infants and children were induced with one or all of the following agents: IL 2, concanavalin ...
G H, Reem, N H, Yeh
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Abstract The role of interleukin 2 (IL 2) on the expression of IL 2 receptors and on the synthesis of gamma-interferon (gamma-IFN) by human thymocytes was investigated. Human thymocytes isolated from specimens obtained during cardiac surgery of infants and children were induced with one or all of the following agents: IL 2, concanavalin ...
G H, Reem, N H, Yeh
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Interleukin 2/interleukin 2 receptor system in type 1 diabetes
Diabetes Research and Clinical Practice, 1989There is increasing evidence that cellular immune abnormalities are involved in the pathogenesis of type 1 diabetes mellitus. The non-obese diabetic (NOD) mouse, a model of human type 1 diabetes, develops mononuclear cell infiltration of its pancreatic islets (insulitis), leading to /3 cell destruction and overt diabetes [l]. In recent studies, most of
Koichi Yokono +4 more
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Survey of Immunologic Research, 1984
Considerable progress has been made in the past year in clarifying the structure-function relationships that are central in controlling T lymphocyte proliferation. Once a cDNA probe for the IL-2 receptor is cloned, all the primary reagents needed for detailed study of the functional consequences of IL-2 binding will be available and one anticipates ...
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Considerable progress has been made in the past year in clarifying the structure-function relationships that are central in controlling T lymphocyte proliferation. Once a cDNA probe for the IL-2 receptor is cloned, all the primary reagents needed for detailed study of the functional consequences of IL-2 binding will be available and one anticipates ...
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Annual Review of Immunology, 2008
Much data support an essential role for interleukin (IL)-2 in immune tolerance. This idea is much different from the early paradigm in which IL-2 is central for protective immune responses. This change in thinking occurred when a T regulatory cell defect was shown to be responsible for the lethal autoimmunity associated with IL-2/IL-2R deficiency. This
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Much data support an essential role for interleukin (IL)-2 in immune tolerance. This idea is much different from the early paradigm in which IL-2 is central for protective immune responses. This change in thinking occurred when a T regulatory cell defect was shown to be responsible for the lethal autoimmunity associated with IL-2/IL-2R deficiency. This
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Interleukin-2, anti-interleukin-2 receptor antibody, and activation of macrophages
Cellular Immunology, 1990Macrophages treated with IFN-gamma and IL-2 before exposure to parasites develop the ability to resist infection with amastigotes of Leishmania major. In this cooperative interaction of cytokines, IL-2 can be replaced with any of several mAb directed against the beta chain of the IL-2 receptor, but not by antibodies to a number of other cell receptors ...
Carol A. Nacy, Miodrag Belosevic
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Interleukin-2 receptor expression and interleukin-2 production in bullous pemphigoid
Archives of Dermatological Research, 1990Expression of interleukin-2 (IL2) receptors was studied on peripheral blood lymphocytes (PBLs) in 25 patients with bullous pemphigoid. Analysis was carried out by flow cytometry. Without immunosuppressive therapy expression of IL2 receptors only on T cells (CD5) was significantly increased as shown by double staining (11.9% +/- 7.8% vs 2.1% +/- 1% in ...
M. Ladusch +3 more
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Cancer Immunotherapy Using Interleukin-2 and Interleukin-2-Activated Lymphocytes
Annual Review of Immunology, 1986The development of immunologic approaches to the treatment of cancer has progressed through major changes in the past five years. In the 1970s considerable enthusiasm existed for immunotherapeutic approaches to cancer based on attempts to provide nonspecific stimulation of the host immune system in the hope that this general increase in immune reactivÂ
M T Lotze, S A Rosenberg
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The released interleukin 2 receptor binds interleukin 2 efficiently.
The Journal of Immunology, 1986Abstract The released interleukin 2 receptor (IL 2R) molecule was characterized in order to clarify its biochemical structure and to determine its functional capacity. Enzymatic digestions demonstrated that the released IL 2R, like the cell surface IL 2R, is a complex glycoprotein, modified by the addition of both N- and O-linked ...
L A, Rubin, G, Jay, D L, Nelson
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