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Pathology, 1991
Following activation in vitro, peripheral blood mononuclear cells (PBMC) express cell-associated interleukin-2 receptors (IL2R). The present study was undertaken to define the proportion of T lymphocyte subsets that express the IL2R (CD25 antigen) upon different mitogenic stimulation.
Lai, FM, Leung, JCK, Lai, KN
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Following activation in vitro, peripheral blood mononuclear cells (PBMC) express cell-associated interleukin-2 receptors (IL2R). The present study was undertaken to define the proportion of T lymphocyte subsets that express the IL2R (CD25 antigen) upon different mitogenic stimulation.
Lai, FM, Leung, JCK, Lai, KN
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Physiologic roles of interleukin-2, interleukin-4, and interleukin-7
Current Opinion in Hematology, 1996The use of gene targeting techniques has led to new insights into the physiologic function of lymphoid growth factors, their receptors, and associated signal transduction molecules in the formation and function of T and B cells. Mice rendered deficient for the growth factors interleukin-2 or interleukin-4 exhibit impairment in certain immune responses ...
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Emerging Drugs, 2000
The development of recombinant interleukin-2 (rIL-2) as a treatment for cancer represented an important milestone in the development of biologic therapies. IL-2 is a natural modulator of the immune system that stimulates specialised immune system cells, namely cytotoxic T-lymphocytes (CTLs) and natural killer cells (NKCs). These cells could potentially
Anagha Gurjal, Philip Agop Philip
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The development of recombinant interleukin-2 (rIL-2) as a treatment for cancer represented an important milestone in the development of biologic therapies. IL-2 is a natural modulator of the immune system that stimulates specialised immune system cells, namely cytotoxic T-lymphocytes (CTLs) and natural killer cells (NKCs). These cells could potentially
Anagha Gurjal, Philip Agop Philip
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The interleukin-2/interleukin-2 receptor system: structural, immunological, and clinical features
International Journal of Clinical & Laboratory Research, 1992Interleukin-2 (IL-2) has been the first and more extensively studied cytokine, in particular for its central role in the mechanisms of cell growth and differentiation. The function of IL-2 is mediated through specific receptors (IL-2R) present on the membrane of reacting cells.
SEMENZATO, GIANPIETRO CARLO +2 more
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Interleukin-2, Autotolerance, and Autoimmunity
1991Insomma se il modello non riesce a trasformare la realta, la realta dovrebbe riuscire a trasformare il modello…. Se le cose stanno cosi, il modello dei modelli dovra servire a ottenere dei modelli trasparenti, diafani, sottili como ragnatele; magari addiritura a dissolvere i modelli, anzi a dissolversi.
José Luis Andreu +4 more
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1985
Publisher Summary This chapter describes certain approaches, which are most useful in the purification and characterization of human IL-2 and which have general applicability throughout the lymphokine field. Interleukin 2 (IL-2, T cell growth factor) is situated at the center of the cascade of antigen-nonspecific factors released during an immune ...
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Publisher Summary This chapter describes certain approaches, which are most useful in the purification and characterization of human IL-2 and which have general applicability throughout the lymphokine field. Interleukin 2 (IL-2, T cell growth factor) is situated at the center of the cascade of antigen-nonspecific factors released during an immune ...
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1998
Die Zellen des Immunsystems, die innerhalb eines Organismus fur die Abwehr von Bakterien, Viren, Pilzen und anderen schadlichen Einflussen zustandig sind, „verstandigen“ sich untereinander auf chemischem Wege. Das heist, sie produzieren eine Vielzahl verschiedener Stoffe, die ins Blut abgegeben werden und fur andere Zellen Signalfunktion haben ...
Hilke Stamatiadis-Smidt +1 more
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Die Zellen des Immunsystems, die innerhalb eines Organismus fur die Abwehr von Bakterien, Viren, Pilzen und anderen schadlichen Einflussen zustandig sind, „verstandigen“ sich untereinander auf chemischem Wege. Das heist, sie produzieren eine Vielzahl verschiedener Stoffe, die ins Blut abgegeben werden und fur andere Zellen Signalfunktion haben ...
Hilke Stamatiadis-Smidt +1 more
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Immunotherapy with Interleukin-2 [PDF]
, 1989 Chemotherapy is capable of producing durable responses in only a few types of advanced cancer and there is therefore an urgent need for alternative approaches to treatment. For decades, immunologists have held the hope that it might be possible to induce or augment a host antitumour response and produce immune-mediated disease regression.
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