Results 1 to 10 of about 3,531,639 (330)
Interleukin-21 in Viral Infections. [PDF]
Int J Mol Sci, 2021 Interleukin (IL)-21 is a cytokine that affects the differentiation and function of lymphoid and myeloid cells and regulates both innate and adaptive immune responses. In addition to regulating the immune response to tumor and viral infections, IL-21 also
Asao H.
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Therapeutic potential of interleukin-21 in cancer. [PDF]
Front ImmunolInterleukin-21 (IL-21) is an immunostimulatory cytokine which belongs to the common gamma-chain family of cytokines. It plays an import role in the development, differentiation, proliferation, and activation of immune cells, in particular T and natural ...
Isvoranu G, Chiritoiu-Butnaru M.
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Upregulation of Interleukin 21 and Interleukin 21 Receptor in Patients with Dermatomyositis and Polymyositis. [PDF]
Chin Med J (Engl), 2017 Background: The immunopathologic mechanism underlying dermatomyositis (DM) and polymyositis (PM) remains poorly understood. Many cytokines play a pathogenic role in DM and PM.
Liu T, Hou Y, Dai TJ, Yan CZ.
europepmc +5 more sources
Interleukin-21 and its association with chronic periodontitis.
J Indian Soc Periodontol, 2019 Context: Interleukin-21 (IL-21) is a pleiotropic cytokine, well documented to contribute to the development of Th17 cells which have been shown to play an important role in the pathogenesis of periodontitis.
Lokhande RV +3 more
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Interleukin‐21 in autoimmune and inflammatory skin diseases [PDF]
European Journal of Immunology, 2023 Studies on the role of interleukins (ILs) in autoimmune and inflammatory diseases allow for the better understanding of pathologic mechanisms of disease and reshaping of treatment modalities.
Alberto Mesas‐Fernández +5 more
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Definitions, 2020 Interleukin-21 (155 aa, ~18 kDa) is encoded by the human IL21 gene. This protein plays a role in both receptor-mediated signaling and the inflammatory response.
semanticscholar +2 more sources
IL21R (interleukin 21 receptor) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on IL21R (interleukin 21 receptor), with data on DNA, on the protein encoded, and where the gene is implicated.
Silvano Ferrini, Marina Fabbi
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Regulation of the germinal center and humoral immunity by interleukin-21. [PDF]
J Exp Med, 2020 Here we review the critical and non-redundant functions of IL-21 in regulating humoral immune responses. We particularly focus on studies in natura—from individuals from inborn errors of immunity that impact on IL-21 production and/or function.
Tangye SG, Ma CS.
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Peripheral TIGIT+ T Follicular Helper Cells That Produce High Levels of Interleukin-21 via OX40 Represent Disease Activity in IgG4-Related Disease. [PDF]
Front Immunol, 2021 Objectives Multiple studies suggest that interleukin (IL)-21 plays a pivotal role in the differentiation of B cells and activation of cytotoxic T cells and is involved in the pathogenesis of IgG4-related disease (IgG4-RD).
Akiyama M +5 more
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A structural blueprint for interleukin-21 signal modulation. [PDF]
Cell Rep, 2023 Interleukin-21 (IL-21) plays a critical role in generating immunological memory by promoting the germinal center reaction, yet clinical use of IL-21 remains challenging because of its pleiotropy and association with autoimmune disease. To better understand the structural basis of IL-21 signaling, we determine the structure of the IL-21-IL-21R-γc ...
Abhiraman GC +9 more
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