Therapeutic potential of interleukin-21 in cancer [PDF]
Frontiers in ImmunologyInterleukin-21 (IL-21) is an immunostimulatory cytokine which belongs to the common gamma-chain family of cytokines. It plays an import role in the development, differentiation, proliferation, and activation of immune cells, in particular T and natural ...
Gheorghita Isvoranu +1 more
doaj +5 more sources
Upregulation of Interleukin 21 and Interleukin 21 Receptor in Patients with Dermatomyositis and Polymyositis [PDF]
Chinese Medical Journal, 2017 Background: The immunopathologic mechanism underlying dermatomyositis (DM) and polymyositis (PM) remains poorly understood. Many cytokines play a pathogenic role in DM and PM.
Tao Liu +3 more
doaj +6 more sources
Interleukin-21 in Viral Infections. [PDF]
Int J Mol Sci, 2021 Interleukin (IL)-21 is a cytokine that affects the differentiation and function of lymphoid and myeloid cells and regulates both innate and adaptive immune responses. In addition to regulating the immune response to tumor and viral infections, IL-21 also has a profound effect on the development of autoimmune and inflammatory diseases. IL-21 is produced
Asao H.
europepmc +5 more sources
Obesity and childhood asthma in male schoolchildren in Saudi Arabia: Is there a role for leptin, interleukin-4, interleukin-5, and interleukin-21? [PDF]
Annals of Saudi Medicine, 2019 BACKGROUND: Adiposity is associated with high serum levels of adipokines and chemokines which are possibly implicated in a co-existence of obesity and asthma.
Mohammed Al-Ayed +12 more
doaj +5 more sources
A structural blueprint for interleukin-21 signal modulation [PDF]
Cell Reports, 2023 Summary: Interleukin-21 (IL-21) plays a critical role in generating immunological memory by promoting the germinal center reaction, yet clinical use of IL-21 remains challenging because of its pleiotropy and association with autoimmune disease. To better
Gita C. Abhiraman +9 more
doaj +4 more sources
The effects of interleukin-21 in the biology of transplant rejection [PDF]
Frontiers in ImmunologyInterleukin-21 (IL-21) is a cytokine that plays a crucial role in regulating immune responses, affecting various immune cell types, including T cells, B cells, natural killer (NK) cells, and dendritic cells.
Xiandong Zeng +7 more
doaj +4 more sources
Interleukin 21 Receptor Affects Adipogenesis of Human Adipose-Derived Stem/Stromal Cells [PDF]
Stem Cells International, 2022 Dysfunctions in adipose tissue cells are responsible for several obesity-related metabolic diseases. Understanding the process of adipocyte formation is thus fundamental for understanding these diseases.
Bruna Cristina Falavinha +7 more
doaj +2 more sources
Elevated plasma interleukin 21 is associated with higher probability and severity of idiopathic membranous nephropathy [PDF]
Journal of Laboratory Medicine, 2023 Interleukin 21 (IL-21) is a receptor participating in innate immunity and correlates with the activation of innate immune cells. We sought to investigate the role of plasma IL-21 in patients with idiopathic membranous nephropathy (IMN).
Liu Miao +11 more
doaj +2 more sources
Interleukin-21 Influences Glioblastoma Course: Biological Mechanisms and Therapeutic Potential [PDF]
Cells, 2023 Brain tumors represent a heterogeneous group of neoplasms involving the brain or nearby tissues, affecting populations of all ages with a high incidence worldwide.
Alberto Repici +9 more
doaj +2 more sources
Plasma interleukin-21 levels and genetic variants are associated with susceptibility to rheumatoid arthritis [PDF]
BMC Musculoskeletal Disorders, 2021 Background Rheumatoid Arthritis (RA) is a chronic inflammatory condition characterized by autoantibodies development and an elevated spectrum of pro-inflammatory cytokines.
Youguo Hao +5 more
doaj +2 more sources