Animal‐Free Setup of a 3D Mature Adipocyte‐Macrophage Co‐Culture to Induce Inflammation In Vitro
Advanced Healthcare Materials, EarlyView.A completely animal‐free 3D co‐culture is developed using human fat cells and immune cells. Animal‐based materials are replaced with gellan gum hydrogel and a serum‐free medium. Immune cells are effectively activated, producing specific inflammatory signals.
Sophia Nowakowski +3 more
wiley +1 more source
Impact of Hemin on Interleukin-21 Levels and Plasma Cells in Transfusion-Dependent Thalassemia with Positive and Negative Allo-Autoantibody. [PDF]
Int J Gen Med, 2023 Tambunan BA, Ugrasena IDG, Aryati A.
europepmc +1 more source
Interleukin-21 and cellular activation concurrently induce potent cytotoxic function and promote antiviral activity in human CD8 T cells [PDF]
, 2010 Anita Parmigiani +4 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.Hybrid NPs are developed as efficient, scalable nanocarriers for in vitro microRNA delivery, ensuring high loading efficiency, controlled release, physiological and long‐term storage stability. They outperform commercial lipid‐based reagents in terms of transfection efficiency and biocompatibility.
Letizia Nicoletti +11 more
wiley +1 more source
Design and Characterization of Novel Antibody-Cytokine Fusion Proteins Based on Interleukin-21. [PDF]
Antibodies (Basel), 2022 Di Nitto C +4 more
europepmc +1 more source
Production of HIV-1 Env-Specific Antibodies Mediating Innate Immune Functions Depends on Cognate Interleukin-21- Secreting CD4 + T Cells [PDF]
, 2021 Jernej Pušnik +7 more
openalex +1 more source
Safety Evaluation of Repeated Application of Polymeric Microarray Patches in Miniature Pigs
Advanced Healthcare Materials, EarlyView.This study demonstrates the safety of repeated application of three types of microarray patches (MAPs), hydrogelforming, dissolving, and implantable, over four weeks in miniature pigs. No adverse skin or systemic effects were observed, supporting the clinical potential of MAPs as safe and effective drug delivery platforms.
Qonita Kurnia Anjani +4 more
wiley +1 more source
Interleukin-21 Is Associated with the Pathogenesis of Lumbar Disc Herniation
Iranian Journal of Allergy, Asthma and Immunology, 2015 Inflammation is an important reaction underlying lumbar disc herniation (LDH). Th17 cells play a critical role in immune activation. Interleukin (IL)-21 controls the functional activity of effector T-helper cells and the differentiation of Th17 cells ...
Huawei Xue +10 more
doaj
Interleukin 21 controls tumour growth and tumour immunosurveillance in colitis-associated tumorigenesis in mice [PDF]
, 2011 Dominik Jauch +6 more
openalex +1 more source
Immunosuppressive Cytokine‐Tethered Hydrogel for Treating Rheumatoid Arthritis
Advanced Healthcare Materials, EarlyView.An injectable hydrogel is developed by chemically tethering IL‐4, an immunosuppressive cytokine, to a hyaluronic acid‐based backbone. The hydrogel reduces joint friction and exerts immunomodulatory effects. In a rheumatoid arthritis (RA) mouse model, it reduced inflammation, preserved cartilage, and promoted anti‐inflammatory immune responses.
Woojin Back +3 more
wiley +1 more source