Interleukin‐21 in autoimmune and inflammatory skin diseases [PDF]
European Journal of Immunology, 2023 AbstractStudies on the role of interleukins (ILs) in autoimmune and inflammatory diseases allow for the better understanding of pathologic mechanisms of disease and reshaping of treatment modalities. The development of monoclonal antibodies targeting specific ILs or IL signaling pathways (i.e., anti‐IL‐17/IL‐23 in psoriasis or anti‐IL‐4/IL‐13 in atopic
Alberto Mesas‐Fernández +5 more
semanticscholar +4 more sources
Decreased Serum Levels of Interleukin-4 and Interleukin-21 in New Pemphigus Vulgaris Patients, but Not Chronic Patients With Inactive Disease Compared to Healthy Controls [PDF]
Dermatology Practical & Conceptual, 2021 Background: Pemphigus is a rare group of autoimmune blistering diseases with unknown etiology and unclear pathogenesis. Pemphigus vulgaris (PV) is the most common subtype, and is characterized by ulcerations or flaccid blisters on mucous membranes and on
Pegah Shahbazian +7 more
doaj +2 more sources
Biological Functions of Interleukin-21 and Its Role in Inflammation [PDF]
The Scientific World Journal, 2007 Interleukin-21 (IL-21), the most recently discovered CD132-dependent cytokine, is mainly produced by activated T lymphocytes, particularly the inflammatory Th17 subset, and is believed to be a key factor in the transition between innate and acquired ...
Martin Pelletier, Denis Girard
doaj +2 more sources
Interleukin 21 Controls mRNA and MicroRNA Expression in CD40-Activated Chronic Lymphocytic Leukemia Cells. [PDF]
PLoS ONE, 2015 Several factors support CLL cell survival in the microenvironment. Under different experimental conditions, IL21 can either induce apoptosis or promote CLL cell survival.
Loris De Cecco +11 more
doaj +3 more sources
OncoImmunology, 2018 Recent advances in cancer treatment with checkpoint blockade of receptors such as CTLA-4 and PD-1 have demonstrated that combinations of agents with complementary immunomodulatory effects have the potential to enhance antitumor activity as compared to ...
Katherine E. Lewis +13 more
doaj +2 more sources
Interleukin-21 and Interleukin-23 levels in familial Mediterranean Fever before and after treatment: the role of cytokines in disease pathogenesis [PDF]
Scientific ReportsIn a previous study, it has been shown that the population of Th17 lymphocytes was increased in patients with FMF. IL-21 and IL-23 play significant roles in the production and differentiation of Th17 cells.
Mutlu Hizal +7 more
doaj +2 more sources
Interleukin 21 Receptor/Ligand Interaction Is Linked to Disease Progression in Pancreatic Cancer [PDF]
Cells, 2019 Pancreatic ductal adenocarcinoma (PDAC) displays a marked fibro-inflammatory microenvironment in which infiltrated immune cells fail to eliminate the tumor cells and often—rather paradoxically—promote tumor progression.
Alica Linnebacher +11 more
doaj +2 more sources
The Effect of Periodontitis on Expression of Interleukin-21: A Systematic Review
International Journal of Inflammation, 2016 Purpose. Inflammation and tissue breakdown are led by an array of inflammatory destructive mediators associated with initiation and progression of inflammatory diseases like periodontitis.
Archana Mootha +4 more
doaj +2 more sources
Egyptian Journal of Medical Human Genetics, 2017 Background: Systemic lupus erythematosus (SLE) is a common autoimmune disorder which commonly results from the combined effects of a large number of genes.
Yasmin Mohamed Ahmed +4 more
doaj +4 more sources
Interleukin 21 (IL-21) regulates chronic allograft vasculopathy (CAV) in murine heart allograft rejection. [PDF]
PLoS ONE, 2019 IL-21 is the most recently discovered common gamma-chain cytokine that promotes persistent T-cell responses in chronic infections, autoimmunity and cancer.
Mithun Khattar +6 more
doaj +2 more sources