Results 191 to 200 of about 3,088,438 (300)

Potential anti-EBV effects associated with elevated interleukin-21 levels: a case report. [PDF]

BMC Infect Dis, 2020
Assing K, Nielsen C, Jakobsen M, Andersen CB, Skogstrand K, Gaini S, Preiss B, Mortensen SB, Skov MN, Rasmussen LD.   +9 more
europepmc   +1 more source

Tryptophan Metabolite Indole‐3‐Aldehyde Induces AhR and c‐MYC Degradation to Promote Tumor Immunogenicity

Advanced Science, EarlyView.
Tryptophan metabolite Indole‐3‐aldehyde (I3A) downregulates cytosolic AhR and p‐ERK/c‐MYC proteins, together enhancing STAT3 phosphorylation and tumor immunogenicity. Overexpression of the Trp metabolic enzyme interleukin‐4‐induced gene‐1 (IL4I1) in tumor cells increases intracellular levels of I3A and enhances tumor immunogenicity.
Lei Cui, Zining Wang, Zixuan Guo, Hongxia Zhang, Yongxiang Liu, Huanling Zhang, Huan Jin, Feifei Xu, Xiaojuan Wang, Chunyuan Xie, Hui Guo, Tiantian Wang, Yanxun Lin, Qi Zhao, Penghui Zhou, Jing Tan, Jin‐Xin Bei, Peng Huang, Jinyun Liu, Xiaojun Xia   +19 more
wiley   +1 more source

Maintenance of Intestinal Th17 Cells and Reduced Microbial Translocation in SIV-infected Rhesus Macaques Treated with Interleukin (IL)-21

, 2013
Suresh Pallikkuth, Luca Micci, Zachary Ende, Robin I. Iriele, Barbara Cervasi, Benton Lawson, Colleen S. McGary, Kenneth A. Rogers, James G. Else, Guido Silvestri, Kirk A. Easley, Jacob D. Estes, François Villinger, Savita Pahwa, Mirko Paiardini   +14 more
openalex   +2 more sources

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

Advanced Science, EarlyView.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin, Lianhua Yin, Weilin Liu, Rui Li, Tao Jiang, Minguang Yang, Yajun Cao, Sinuo Wang, Yan Yu, Cong Chen, Xiaoqin Guo, Wenju Wang, Huanhuan Liu, Yaling Dai, Jiamin Yan, Yanting Lin, Yanyi Ding, Chendong Ruan, Lei Yang, Tiecheng Wu, Jing Tao, Lidian Chen   +21 more
wiley   +1 more source

Rational Design of Inner Ear Drug Delivery Systems

Advanced Science, EarlyView.
Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu, Zhiyan Xuan, Haoyu Ren, Keng Chen, Hui Zhang, Huan Wang   +5 more
wiley   +1 more source

β‐Glucuronidase‐Expressing Lactobacillus reuteri Triggers Irinotecan Enterotoxicity Through Depleting the Regenerative Epithelial Stem/Progenitor Pool

Advanced Science, EarlyView.
XLP mitigated CPT11 mucositis by suppressing GUS‐expressing microbes, notably L. reuteri, and diminishing bacterial GUS activity, consequently reducing SN38 accumulation to protect the intestinal epithelium. This preservation of the mucosal stem cell niche enabled rapid regeneration of secretory lineages such as mucin‐producing goblet cells, which ...
Bei Yue, Ruiyang Gao, Ling Zhao, Donghui Liu, Cheng Lv, Ziyi Wang, Fangbin Ai, Beibei Zhang, Zhilun Yu, Xiaolong Geng, Hao Wang, Kang Wang, Kaixian Chen, Chenghai Liu, Zhengtao Wang, Wei Dou   +15 more
wiley   +1 more source

Supplementary Figures 1 - 7 from Interleukin 21–Induced Granzyme B–Expressing B Cells Infiltrate Tumors and Regulate T Cells

, 2023
Stefanie Lindner, Karen Dahlke, Kai Sontheimer, Magdalena Hagn, Christof Kaltenmeier, Thomas F.E. Barth, Thamara Beyer, Frank Reister, Dorit Fabricius, Ramin Lotfi, Oleg Lunov, G. Ulrich Nienhaus, Thomas Simmet, R. Kreienberg, Peter Möller, Hubert Schrezenmeier, Bernd Jahrsdörfer   +16 more
openalex   +2 more sources

Induction of interleukin 21 receptor expression via enhanced intracellular metabolism in B cells and its relevance to the disease activity in systemic lupus erythematosus. [PDF]

RMD Open
Ueno M, Iwata S, Yamagata K, Todoroki Y, Sonomoto K, Nagayasu A, Miyagawa I, Kubo S, Miyazaki Y, Miyata H, Kanda R, Aritomi T, Nakayamada S, Tanaka Y.   +13 more
europepmc   +1 more source

Adenovirus-mediated overexpression of interleukin-21 regulates the development of oral squamous cell carcinoma in vitro. [PDF]

Oncol Lett, 2020
Liu H, Liu P, Sun D, Xing D, Wang X, Yang J, Wang S.   +6 more
europepmc   +1 more source

Interleukin‐21 Induces Proliferation and Proinflammatory Cytokine Profile of Fibroblast‐like Synoviocytes of Patients with Rheumatoid Arthritis

Scandinavian Journal of Immunology, 2016
R. Xing, Lin Yang, Yinji Jin, Lin Sun, Chang-hong Li, Zhengqian Li, Jinxia Zhao, Xiangyuan Liu   +7 more
semanticscholar   +1 more source