Results 281 to 290 of about 3,531,639 (330)
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Interleukin‐21 in chronic inflammatory diseases
BioFactors, 2013Interleukin‐21 (IL‐21), a cytokine produced by various subsets of activated CD4+ T cells, regulates multiple innate and adaptive immune responses. Indeed, IL‐21 controls the proliferation and function of CD4+ and CD8+ T lymphocytes, drives the differentiation of B cells into memory cells and Ig‐secreting plasma cells, enhances the activity of natural ...
Sarra, M +2 more
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Interleukin-21: An Interleukin-2 Dependent Player in Rejection Processes
Transplantation, 2007Interleukin (IL)-21 is the most recently described cytokine that signals via the common cytokine receptor (gammac), is produced by activated CD4+ T-cells, and regulates expansion and effector function of CD8+ T-cells.To explore the actions of IL-21 with other gammac-dependent cytokines in alloreactivity, mRNA expression of IL-21, IL-21R alpha-chain ...
Baan, Carla +9 more
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Optimization of interleukin-21 immunotherapeutic strategies
Journal of Theoretical Biology, 2007The recently discovered interleukin-21 (IL-21) shows strong tumor attenuation in preclinical studies, and is considered a promising cancer immunotherapy agent. Yet, to exploit its potential, therapeutic strategies must be designed to achieve adequate balance between several conflicting aspects.
Cappuccio, Antonio +2 more
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Targeting interleukin-21 in inflammatory diseases
Expert Opinion on Therapeutic Targets, 2011IL-21, a new member of the type 1 cytokine superfamily, is produced by various subsets of CD4(+) T cells and binds to a composite receptor that consists of a specific receptor, termed IL-21 receptor and the common γ-chain subunit. Initially considered to be a critical regulator of T and B cell function, IL-21 is now known to regulate the activity of ...
Sarra, M +3 more
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Targeting interleukin-21 in rheumatoid arthritis
Molecular Biology Reports, 2010Interleukin-21 (IL-21) is a new member of the type I cytokine superfamily, which binds to a composite receptor that consists of a private receptor (IL-21R) and the common cytokine receptor γ chain. Recently, increasing evidence has shown that IL-21 contributes to the pathogenesis of chronic inflammatory and autoimmune diseases because of its pro ...
Feng-Lai, Yuan +8 more
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Targeting Interleukin-21 in Immune-Mediated Pathologies
Current Drug Targets, 2010Interleukin (IL)-21, a cytokine mostly produced by activated CD4+ T cells, has been reported to play an important role in the tissue-damaging immune response in various organs. This pathogenic effect is strictly linked to the ability of IL-21 to control the functional activities of multiple immune and non-immune cells. For instance, IL-21 regulates the
Sarra, M +3 more
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Interleukin-21 (IL-21) Controls Inflammatory Pathways in the Gut
Endocrine‚ Metabolic & Immune Disorders-Drug Targets, 2007In both Crohn's disease (CD) and ulcerative colitis (UC), the major forms of inflammatory bowel diseases (IBD) in humans, the pathologic process consists of an aberrant local immune response to components of the bacterial microflora, due to abnormally strong effector cell activity that is poorly controlled by counter-regulatory mechanisms.
Fina D. +3 more
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Interleukin-21 in Immune and Allergic Diseases
Inflammation & Allergy-Drug Targets, 2012Interleukin-21 (IL-21), a cytokine produced by various subsets of activated CD4+ T cells, plays a major role in the control of innate and adaptive immune responses. IL-21 biological activity is mediated by binding of the cytokine to a heterodimeric receptor, composed of a specific subunit, termed IL-21 receptor (IL-21R), and the common γ-chain, that is
Sarra, M +3 more
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Interleukin-21 mRNA expression during virus infections
Cytokine, 2006Interleukin-21 is a cytokine with profound impact on the proliferation and differentiation of activated leukocytes of both the innate and adaptive immune system. In experiments in vitro, antigen activation induces IL-21 production in CD4+ T cells. Where, when, and how the proliferative and activational effects of IL-21 on different leukocytes come into
Holm, Christian +5 more
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Interleukin 21: combination strategies for cancer therapy
Nature Reviews Drug Discovery, 2008In the past 20 years researchers have attempted to activate the host immune defence system to kill tumour cells and eradicate cancer. In some cases, the response of patients to immunotherapy has been extremely successful; however, other trials have shown disappointing results, and so there is a clear need for more effective therapies that can ...
Skak, Kresten +4 more
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